Contribution of non-circadian neurons to the temporal organization of locomotor activity
In the fruit fly, Drosophila melanogaster, the daily cycle of rest and activity is a rhythmic behavior that relies on the activity of a small number of neurons. The small ventral lateral neurons (sLNvs) are considered key in the control of locomotor rhythmicity. Previous work from our laboratory has...
Guardado en:
| Publicado: |
2019
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_20466390_v8_n1_p_Pırez http://hdl.handle.net/20.500.12110/paper_20466390_v8_n1_p_Pırez |
| Aporte de: |
| id |
paper:paper_20466390_v8_n1_p_Pñrez |
|---|---|
| record_format |
dspace |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Connectivity Drosophila Locomotor rhythms Non-circadian neurons SLNvs article Drosophila excitability fluorescence imaging locomotion membrane nonhuman rhythm synapse |
| spellingShingle |
Connectivity Drosophila Locomotor rhythms Non-circadian neurons SLNvs article Drosophila excitability fluorescence imaging locomotion membrane nonhuman rhythm synapse Contribution of non-circadian neurons to the temporal organization of locomotor activity |
| topic_facet |
Connectivity Drosophila Locomotor rhythms Non-circadian neurons SLNvs article Drosophila excitability fluorescence imaging locomotion membrane nonhuman rhythm synapse |
| description |
In the fruit fly, Drosophila melanogaster, the daily cycle of rest and activity is a rhythmic behavior that relies on the activity of a small number of neurons. The small ventral lateral neurons (sLNvs) are considered key in the control of locomotor rhythmicity. Previous work from our laboratory has showed that these neurons undergo structural remodeling on their axonal projections on a daily basis. Such remodeling endows sLNvs with the possibility to make synaptic contacts with different partners at different times throughout the day, as has been previously described. By using different genetic tools to alter membrane excitability of the sLNv putative postsynaptic partners, we tested their functional role in the control of locomotor activity. We also used optical imaging to test the functionality of these contacts. We found that these different neuronal groups affect the consolidation of rhythmic activity, suggesting that non-circadian cells are part of the circuit that controls locomotor activity. Our results suggest that new neuronal groups, in addition to the well-characterized clock neurons, contribute to the operations of the circadian network that controls locomotor activity in D. melanogaster. © 2019. Published by The Company of Biologists Ltd. |
| title |
Contribution of non-circadian neurons to the temporal organization of locomotor activity |
| title_short |
Contribution of non-circadian neurons to the temporal organization of locomotor activity |
| title_full |
Contribution of non-circadian neurons to the temporal organization of locomotor activity |
| title_fullStr |
Contribution of non-circadian neurons to the temporal organization of locomotor activity |
| title_full_unstemmed |
Contribution of non-circadian neurons to the temporal organization of locomotor activity |
| title_sort |
contribution of non-circadian neurons to the temporal organization of locomotor activity |
| publishDate |
2019 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_20466390_v8_n1_p_Pırez http://hdl.handle.net/20.500.12110/paper_20466390_v8_n1_p_Pırez |
| bdutipo_str |
Repositorios |
| _version_ |
1764820568746491907 |