Pedunculopontine arousal system physiology - Implications for insomnia

We consider insomnia a disorder of waking rather than a disorder of sleep. This review examines the role of the reticular activating system, especially the pedunculopontine nucleus, in the symptoms of insomnia, mainly representing an overactive waking drive. We determined that high frequency activit...

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Publicado:	2015
Materias:	Calcium channels Gamma band activity N-type calcium channel Neuronal calcium sensor protein P/Q-type calcium channel benzodiazepine derivative calcium calmodulin dependent protein kinase II calcium channel N type calcium channel P type calcium channel Q type cyclic AMP dependent protein kinase hypnotic agent kainic acid lithium n methyl dextro aspartic acid n [2 [[n [3 (4 chlorophenyl) 2 propenyl] n methylamino] methyl]phenyl] n (2 hydroxyethyl) 4 methoxybenzenesulfonamide neuronal calcium sensor omega agatoxin IVA omega conotoxin GVIA protein kinase C unclassified drug arousal Article bipolar disorder cognitive therapy daytime somnolence electroencephalography habituation hallucination hippocampus human insomnia nightmare pedunculopontine tegmental nucleus REM sleep reticular formation schizophrenia sleep waking cycle substantia nigra pars compacta wakefulness
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19840659_v8_n2_p92_GarciaRilla http://hdl.handle.net/20.500.12110/paper_19840659_v8_n2_p92_GarciaRilla
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_19840659_v8_n2_p92_GarciaRilla
record_format	dspace
spelling	paper:paper_19840659_v8_n2_p92_GarciaRilla2023-06-08T16:32:46Z Pedunculopontine arousal system physiology - Implications for insomnia Calcium channels Gamma band activity N-type calcium channel Neuronal calcium sensor protein P/Q-type calcium channel benzodiazepine derivative calcium calmodulin dependent protein kinase II calcium channel N type calcium channel P type calcium channel Q type cyclic AMP dependent protein kinase hypnotic agent kainic acid lithium n methyl dextro aspartic acid n [2 [[n [3 (4 chlorophenyl) 2 propenyl] n methylamino] methyl]phenyl] n (2 hydroxyethyl) 4 methoxybenzenesulfonamide neuronal calcium sensor omega agatoxin IVA omega conotoxin GVIA protein kinase C unclassified drug arousal Article bipolar disorder cognitive therapy daytime somnolence electroencephalography habituation hallucination hippocampus human insomnia nightmare pedunculopontine tegmental nucleus REM sleep reticular formation schizophrenia sleep waking cycle substantia nigra pars compacta wakefulness We consider insomnia a disorder of waking rather than a disorder of sleep. This review examines the role of the reticular activating system, especially the pedunculopontine nucleus, in the symptoms of insomnia, mainly representing an overactive waking drive. We determined that high frequency activity during waking and REM sleep is controlled by two different intracellular pathways and channel types in PPN cells. We found three different PPN cell types that have one or both channels and may be active during waking only, REM sleep only, or both. These discoveries point to a specific mechanism and novel therapeutic avenues for insomnia. © 2015 Brazilian Association of Sleep. 2015 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19840659_v8_n2_p92_GarciaRilla http://hdl.handle.net/20.500.12110/paper_19840659_v8_n2_p92_GarciaRilla
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Calcium channels Gamma band activity N-type calcium channel Neuronal calcium sensor protein P/Q-type calcium channel benzodiazepine derivative calcium calmodulin dependent protein kinase II calcium channel N type calcium channel P type calcium channel Q type cyclic AMP dependent protein kinase hypnotic agent kainic acid lithium n methyl dextro aspartic acid n [2 [[n [3 (4 chlorophenyl) 2 propenyl] n methylamino] methyl]phenyl] n (2 hydroxyethyl) 4 methoxybenzenesulfonamide neuronal calcium sensor omega agatoxin IVA omega conotoxin GVIA protein kinase C unclassified drug arousal Article bipolar disorder cognitive therapy daytime somnolence electroencephalography habituation hallucination hippocampus human insomnia nightmare pedunculopontine tegmental nucleus REM sleep reticular formation schizophrenia sleep waking cycle substantia nigra pars compacta wakefulness
spellingShingle	Calcium channels Gamma band activity N-type calcium channel Neuronal calcium sensor protein P/Q-type calcium channel benzodiazepine derivative calcium calmodulin dependent protein kinase II calcium channel N type calcium channel P type calcium channel Q type cyclic AMP dependent protein kinase hypnotic agent kainic acid lithium n methyl dextro aspartic acid n [2 [[n [3 (4 chlorophenyl) 2 propenyl] n methylamino] methyl]phenyl] n (2 hydroxyethyl) 4 methoxybenzenesulfonamide neuronal calcium sensor omega agatoxin IVA omega conotoxin GVIA protein kinase C unclassified drug arousal Article bipolar disorder cognitive therapy daytime somnolence electroencephalography habituation hallucination hippocampus human insomnia nightmare pedunculopontine tegmental nucleus REM sleep reticular formation schizophrenia sleep waking cycle substantia nigra pars compacta wakefulness Pedunculopontine arousal system physiology - Implications for insomnia
topic_facet	Calcium channels Gamma band activity N-type calcium channel Neuronal calcium sensor protein P/Q-type calcium channel benzodiazepine derivative calcium calmodulin dependent protein kinase II calcium channel N type calcium channel P type calcium channel Q type cyclic AMP dependent protein kinase hypnotic agent kainic acid lithium n methyl dextro aspartic acid n [2 [[n [3 (4 chlorophenyl) 2 propenyl] n methylamino] methyl]phenyl] n (2 hydroxyethyl) 4 methoxybenzenesulfonamide neuronal calcium sensor omega agatoxin IVA omega conotoxin GVIA protein kinase C unclassified drug arousal Article bipolar disorder cognitive therapy daytime somnolence electroencephalography habituation hallucination hippocampus human insomnia nightmare pedunculopontine tegmental nucleus REM sleep reticular formation schizophrenia sleep waking cycle substantia nigra pars compacta wakefulness
description	We consider insomnia a disorder of waking rather than a disorder of sleep. This review examines the role of the reticular activating system, especially the pedunculopontine nucleus, in the symptoms of insomnia, mainly representing an overactive waking drive. We determined that high frequency activity during waking and REM sleep is controlled by two different intracellular pathways and channel types in PPN cells. We found three different PPN cell types that have one or both channels and may be active during waking only, REM sleep only, or both. These discoveries point to a specific mechanism and novel therapeutic avenues for insomnia. © 2015 Brazilian Association of Sleep.
title	Pedunculopontine arousal system physiology - Implications for insomnia
title_short	Pedunculopontine arousal system physiology - Implications for insomnia
title_full	Pedunculopontine arousal system physiology - Implications for insomnia
title_fullStr	Pedunculopontine arousal system physiology - Implications for insomnia
title_full_unstemmed	Pedunculopontine arousal system physiology - Implications for insomnia
title_sort	pedunculopontine arousal system physiology - implications for insomnia
publishDate	2015
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19840659_v8_n2_p92_GarciaRilla http://hdl.handle.net/20.500.12110/paper_19840659_v8_n2_p92_GarciaRilla
_version_	1768544707625877504

Pedunculopontine arousal system physiology - Implications for insomnia

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