Pedunculopontine arousal system physiology—implications for schizophrenia
Schizophrenia is characterized by major sleep/wake disturbances including increased vigilance and arousal, decreased slow wave sleep, and increased REM sleep drive. Other arousal- related symptoms include sensory gating deficits as exemplified by decreased habituation of the blink reflex. There is...
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2015
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19840659_v8_n2_p82_GarciaRilla http://hdl.handle.net/20.500.12110/paper_19840659_v8_n2_p82_GarciaRilla |
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paper:paper_19840659_v8_n2_p82_GarciaRilla2023-06-08T16:32:46Z Pedunculopontine arousal system physiology—implications for schizophrenia Calcium channels Gamma band activity Neuronal calcium sensor protein P50 potential 4 aminobutyric acid calcium channel N type calcium channel P type calcium channel Q type chlorpromazine clozapine dopamine haloperidol lithium modafinil muscarinic receptor n methyl dextro aspartic acid n [2 [[n [3 (4 chlorophenyl) 2 propenyl] n methylamino] methyl]phenyl] n (2 hydroxyethyl) 4 methoxybenzenesulfonamide neuronal calcium sensor olanzapine serotonin receptor tetrodotoxin unclassified drug arousal Article bipolar disorder dyskinesia human Parkinson disease pedunculopontine tegmental nucleus physiology REM sleep reticular formation schizophrenia substantia nigra thalamus wakefulness Schizophrenia is characterized by major sleep/wake disturbances including increased vigilance and arousal, decreased slow wave sleep, and increased REM sleep drive. Other arousal- related symptoms include sensory gating deficits as exemplified by decreased habituation of the blink reflex. There is also dysregulation of gamma band activity, suggestive of disturbances in a host of arousal-related mechanisms. This review examines the role of the reticular activating system, especially the pedunculopontine nucleus, in the symptoms of the disease. Recent discoveries on the physiology of the pedunculopontine nucleus help explain many of these disorders of arousal in, and point to novel therapeutic avenues for, schizophrenia. © 2015 Brazilian Association of Sleep. 2015 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19840659_v8_n2_p82_GarciaRilla http://hdl.handle.net/20.500.12110/paper_19840659_v8_n2_p82_GarciaRilla |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Calcium channels Gamma band activity Neuronal calcium sensor protein P50 potential 4 aminobutyric acid calcium channel N type calcium channel P type calcium channel Q type chlorpromazine clozapine dopamine haloperidol lithium modafinil muscarinic receptor n methyl dextro aspartic acid n [2 [[n [3 (4 chlorophenyl) 2 propenyl] n methylamino] methyl]phenyl] n (2 hydroxyethyl) 4 methoxybenzenesulfonamide neuronal calcium sensor olanzapine serotonin receptor tetrodotoxin unclassified drug arousal Article bipolar disorder dyskinesia human Parkinson disease pedunculopontine tegmental nucleus physiology REM sleep reticular formation schizophrenia substantia nigra thalamus wakefulness |
| spellingShingle |
Calcium channels Gamma band activity Neuronal calcium sensor protein P50 potential 4 aminobutyric acid calcium channel N type calcium channel P type calcium channel Q type chlorpromazine clozapine dopamine haloperidol lithium modafinil muscarinic receptor n methyl dextro aspartic acid n [2 [[n [3 (4 chlorophenyl) 2 propenyl] n methylamino] methyl]phenyl] n (2 hydroxyethyl) 4 methoxybenzenesulfonamide neuronal calcium sensor olanzapine serotonin receptor tetrodotoxin unclassified drug arousal Article bipolar disorder dyskinesia human Parkinson disease pedunculopontine tegmental nucleus physiology REM sleep reticular formation schizophrenia substantia nigra thalamus wakefulness Pedunculopontine arousal system physiology—implications for schizophrenia |
| topic_facet |
Calcium channels Gamma band activity Neuronal calcium sensor protein P50 potential 4 aminobutyric acid calcium channel N type calcium channel P type calcium channel Q type chlorpromazine clozapine dopamine haloperidol lithium modafinil muscarinic receptor n methyl dextro aspartic acid n [2 [[n [3 (4 chlorophenyl) 2 propenyl] n methylamino] methyl]phenyl] n (2 hydroxyethyl) 4 methoxybenzenesulfonamide neuronal calcium sensor olanzapine serotonin receptor tetrodotoxin unclassified drug arousal Article bipolar disorder dyskinesia human Parkinson disease pedunculopontine tegmental nucleus physiology REM sleep reticular formation schizophrenia substantia nigra thalamus wakefulness |
| description |
Schizophrenia is characterized by major sleep/wake disturbances including increased vigilance and arousal, decreased slow wave sleep, and increased REM sleep drive. Other arousal- related symptoms include sensory gating deficits as exemplified by decreased habituation of the blink reflex. There is also dysregulation of gamma band activity, suggestive of disturbances in a host of arousal-related mechanisms. This review examines the role of the reticular activating system, especially the pedunculopontine nucleus, in the symptoms of the disease. Recent discoveries on the physiology of the pedunculopontine nucleus help explain many of these disorders of arousal in, and point to novel therapeutic avenues for, schizophrenia. © 2015 Brazilian Association of Sleep. |
| title |
Pedunculopontine arousal system physiology—implications for schizophrenia |
| title_short |
Pedunculopontine arousal system physiology—implications for schizophrenia |
| title_full |
Pedunculopontine arousal system physiology—implications for schizophrenia |
| title_fullStr |
Pedunculopontine arousal system physiology—implications for schizophrenia |
| title_full_unstemmed |
Pedunculopontine arousal system physiology—implications for schizophrenia |
| title_sort |
pedunculopontine arousal system physiology—implications for schizophrenia |
| publishDate |
2015 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19840659_v8_n2_p82_GarciaRilla http://hdl.handle.net/20.500.12110/paper_19840659_v8_n2_p82_GarciaRilla |
| _version_ |
1768543630949089280 |