Theoretical biology: Response to comment on "'Load-induced modulation of signal transduction networks': Reconciling ultrasensitivity with bifunctionality?"

Straube suggests that a model that reflects the bifunctional nature of the cycle enzyme uridylyltransferase/uridylyl-removing enzyme (UTase/UR) should be used, in which the UT and UR activities are distinct and reciprocally regulated activity states of the enzyme, and notes that if such a model is u...

Descripción completa

Guardado en:

Detalles Bibliográficos
Publicado:	2012
Materias:	hexose 1 phosphate uridylyltransferase article enzyme activation enzyme activity enzyme regulation Escherichia coli modulation nonhuman prediction priority journal signal transduction
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19450877_v5_n205_p_Jiang http://hdl.handle.net/20.500.12110/paper_19450877_v5_n205_p_Jiang
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_19450877_v5_n205_p_Jiang
record_format	dspace
spelling	paper:paper_19450877_v5_n205_p_Jiang2023-06-08T16:32:29Z Theoretical biology: Response to comment on "'Load-induced modulation of signal transduction networks': Reconciling ultrasensitivity with bifunctionality?" hexose 1 phosphate uridylyltransferase article enzyme activation enzyme activity enzyme regulation Escherichia coli modulation nonhuman prediction priority journal signal transduction Straube suggests that a model that reflects the bifunctional nature of the cycle enzyme uridylyltransferase/uridylyl-removing enzyme (UTase/UR) should be used, in which the UT and UR activities are distinct and reciprocally regulated activity states of the enzyme, and notes that if such a model is used, the effects of retroactivity at intermediate stimulation will be different. However, such a model does not accurately match the observed enzyme regulatory properties and fails to predict the ultrasensitive response obtained in the experiments. Here, we argue that modeling the UTase/UR enzyme as a bifunctional enzyme with reciprocally regulated activity states misses important aspects of the system. 2012 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19450877_v5_n205_p_Jiang http://hdl.handle.net/20.500.12110/paper_19450877_v5_n205_p_Jiang
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	hexose 1 phosphate uridylyltransferase article enzyme activation enzyme activity enzyme regulation Escherichia coli modulation nonhuman prediction priority journal signal transduction
spellingShingle	hexose 1 phosphate uridylyltransferase article enzyme activation enzyme activity enzyme regulation Escherichia coli modulation nonhuman prediction priority journal signal transduction Theoretical biology: Response to comment on "'Load-induced modulation of signal transduction networks': Reconciling ultrasensitivity with bifunctionality?"
topic_facet	hexose 1 phosphate uridylyltransferase article enzyme activation enzyme activity enzyme regulation Escherichia coli modulation nonhuman prediction priority journal signal transduction
description	Straube suggests that a model that reflects the bifunctional nature of the cycle enzyme uridylyltransferase/uridylyl-removing enzyme (UTase/UR) should be used, in which the UT and UR activities are distinct and reciprocally regulated activity states of the enzyme, and notes that if such a model is used, the effects of retroactivity at intermediate stimulation will be different. However, such a model does not accurately match the observed enzyme regulatory properties and fails to predict the ultrasensitive response obtained in the experiments. Here, we argue that modeling the UTase/UR enzyme as a bifunctional enzyme with reciprocally regulated activity states misses important aspects of the system.
title	Theoretical biology: Response to comment on "'Load-induced modulation of signal transduction networks': Reconciling ultrasensitivity with bifunctionality?"
title_short	Theoretical biology: Response to comment on "'Load-induced modulation of signal transduction networks': Reconciling ultrasensitivity with bifunctionality?"
title_full	Theoretical biology: Response to comment on "'Load-induced modulation of signal transduction networks': Reconciling ultrasensitivity with bifunctionality?"
title_fullStr	Theoretical biology: Response to comment on "'Load-induced modulation of signal transduction networks': Reconciling ultrasensitivity with bifunctionality?"
title_full_unstemmed	Theoretical biology: Response to comment on "'Load-induced modulation of signal transduction networks': Reconciling ultrasensitivity with bifunctionality?"
title_sort	theoretical biology: response to comment on "'load-induced modulation of signal transduction networks': reconciling ultrasensitivity with bifunctionality?"
publishDate	2012
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19450877_v5_n205_p_Jiang http://hdl.handle.net/20.500.12110/paper_19450877_v5_n205_p_Jiang
_version_	1768545210539704320

Theoretical biology: Response to comment on "'Load-induced modulation of signal transduction networks': Reconciling ultrasensitivity with bifunctionality?"

Ejemplares similares