Retroactive signaling in short signaling pathways

In biochemical signaling pathways without explicit feedback connections, the core signal transduction is usually described as a one-way communication, going from upstream to downstream in a feedforward chain or network of covalent modification cycles. In this paper we explore the possibility of a ne...

Descripción completa

Guardado en:

Detalles Bibliográficos
Publicado:	2012
Materias:	phosphatase article enzyme inactivation intracellular signaling negative feedback positive feedback protein analysis protein modification retroactive signaling signal transduction Enzyme Activation Models, Biological Phosphoprotein Phosphatases Signal Transduction
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19326203_v7_n7_p_Sepulchre http://hdl.handle.net/20.500.12110/paper_19326203_v7_n7_p_Sepulchre
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_19326203_v7_n7_p_Sepulchre
record_format	dspace
spelling	paper:paper_19326203_v7_n7_p_Sepulchre2023-06-08T16:31:08Z Retroactive signaling in short signaling pathways phosphatase article enzyme inactivation intracellular signaling negative feedback positive feedback protein analysis protein modification retroactive signaling signal transduction Enzyme Activation Models, Biological Phosphoprotein Phosphatases Signal Transduction In biochemical signaling pathways without explicit feedback connections, the core signal transduction is usually described as a one-way communication, going from upstream to downstream in a feedforward chain or network of covalent modification cycles. In this paper we explore the possibility of a new type of signaling called retroactive signaling, offered by the recently demonstrated property of retroactivity in signaling cascades. The possibility of retroactive signaling is analysed in the simplest case of the stationary states of a bicyclic cascade of signaling cycles. In this case, we work out the conditions for which variables of the upstream cycle are affected by a change of the total amount of protein in the downstream cycle, or by a variation of the phosphatase deactivating the same protein. Particularly, we predict the characteristic ranges of the downstream protein, or of the downstream phosphatase, for which a retroactive effect can be observed on the upstream cycle variables. Next, we extend the possibility of retroactive signaling in short but nonlinear signaling pathways involving a few covalent modification cycles. © 2012 Sepulchre et al. 2012 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19326203_v7_n7_p_Sepulchre http://hdl.handle.net/20.500.12110/paper_19326203_v7_n7_p_Sepulchre
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	phosphatase article enzyme inactivation intracellular signaling negative feedback positive feedback protein analysis protein modification retroactive signaling signal transduction Enzyme Activation Models, Biological Phosphoprotein Phosphatases Signal Transduction
spellingShingle	phosphatase article enzyme inactivation intracellular signaling negative feedback positive feedback protein analysis protein modification retroactive signaling signal transduction Enzyme Activation Models, Biological Phosphoprotein Phosphatases Signal Transduction Retroactive signaling in short signaling pathways
topic_facet	phosphatase article enzyme inactivation intracellular signaling negative feedback positive feedback protein analysis protein modification retroactive signaling signal transduction Enzyme Activation Models, Biological Phosphoprotein Phosphatases Signal Transduction
description	In biochemical signaling pathways without explicit feedback connections, the core signal transduction is usually described as a one-way communication, going from upstream to downstream in a feedforward chain or network of covalent modification cycles. In this paper we explore the possibility of a new type of signaling called retroactive signaling, offered by the recently demonstrated property of retroactivity in signaling cascades. The possibility of retroactive signaling is analysed in the simplest case of the stationary states of a bicyclic cascade of signaling cycles. In this case, we work out the conditions for which variables of the upstream cycle are affected by a change of the total amount of protein in the downstream cycle, or by a variation of the phosphatase deactivating the same protein. Particularly, we predict the characteristic ranges of the downstream protein, or of the downstream phosphatase, for which a retroactive effect can be observed on the upstream cycle variables. Next, we extend the possibility of retroactive signaling in short but nonlinear signaling pathways involving a few covalent modification cycles. © 2012 Sepulchre et al.
title	Retroactive signaling in short signaling pathways
title_short	Retroactive signaling in short signaling pathways
title_full	Retroactive signaling in short signaling pathways
title_fullStr	Retroactive signaling in short signaling pathways
title_full_unstemmed	Retroactive signaling in short signaling pathways
title_sort	retroactive signaling in short signaling pathways
publishDate	2012
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19326203_v7_n7_p_Sepulchre http://hdl.handle.net/20.500.12110/paper_19326203_v7_n7_p_Sepulchre
_version_	1768543203981524992

Retroactive signaling in short signaling pathways

Ejemplares similares