Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness
Resting state functional magnetic resonance imaging (rs-fMRI) in infants enables important studies of functional brain organization early in human development. However, rs-fMRI in infants has universally been obtained during sleep to reduce participant motion artifact, raising the question of whethe...
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2017
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19326203_v12_n11_p_Mitra http://hdl.handle.net/20.500.12110/paper_19326203_v12_n11_p_Mitra |
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paper:paper_19326203_v12_n11_p_Mitra2023-06-08T16:30:37Z Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness BOLD signal child controlled study default mode network drawing female functional connectivity functional magnetic resonance imaging human human experiment infant male nonREM sleep preschool child rest thalamus wakefulness adult anatomy and histology brain connectome electroencephalography growth, development and aging nuclear magnetic resonance imaging physiology principal component analysis sleep statistics and numerical data wakefulness Adult Brain Child, Preschool Connectome Electroencephalography Humans Infant Magnetic Resonance Imaging Principal Component Analysis Sleep Wakefulness Resting state functional magnetic resonance imaging (rs-fMRI) in infants enables important studies of functional brain organization early in human development. However, rs-fMRI in infants has universally been obtained during sleep to reduce participant motion artifact, raising the question of whether differences in functional organization between awake adults and sleeping infants that are commonly attributed to development may instead derive, at least in part, from sleep. This question is especially important as rs-fMRI differences in adult wake vs. sleep are well documented. To investigate this question, we compared functional connectivity and BOLD signal propagation patterns in 6, 12, and 24 month old sleeping infants with patterns in adult wakefulness and non-REM sleep. We find that important functional connectivity features seen during infant sleep closely resemble those seen during adult sleep, including reduced default mode network functional connectivity. However, we also find differences between infant and adult sleep, especially in thalamic BOLD signal propagation patterns. These findings highlight the importance of considering sleep state when drawing developmental inferences in infant rs-fMRI. © 2017 Mitra et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 2017 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19326203_v12_n11_p_Mitra http://hdl.handle.net/20.500.12110/paper_19326203_v12_n11_p_Mitra |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
BOLD signal child controlled study default mode network drawing female functional connectivity functional magnetic resonance imaging human human experiment infant male nonREM sleep preschool child rest thalamus wakefulness adult anatomy and histology brain connectome electroencephalography growth, development and aging nuclear magnetic resonance imaging physiology principal component analysis sleep statistics and numerical data wakefulness Adult Brain Child, Preschool Connectome Electroencephalography Humans Infant Magnetic Resonance Imaging Principal Component Analysis Sleep Wakefulness |
| spellingShingle |
BOLD signal child controlled study default mode network drawing female functional connectivity functional magnetic resonance imaging human human experiment infant male nonREM sleep preschool child rest thalamus wakefulness adult anatomy and histology brain connectome electroencephalography growth, development and aging nuclear magnetic resonance imaging physiology principal component analysis sleep statistics and numerical data wakefulness Adult Brain Child, Preschool Connectome Electroencephalography Humans Infant Magnetic Resonance Imaging Principal Component Analysis Sleep Wakefulness Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness |
| topic_facet |
BOLD signal child controlled study default mode network drawing female functional connectivity functional magnetic resonance imaging human human experiment infant male nonREM sleep preschool child rest thalamus wakefulness adult anatomy and histology brain connectome electroencephalography growth, development and aging nuclear magnetic resonance imaging physiology principal component analysis sleep statistics and numerical data wakefulness Adult Brain Child, Preschool Connectome Electroencephalography Humans Infant Magnetic Resonance Imaging Principal Component Analysis Sleep Wakefulness |
| description |
Resting state functional magnetic resonance imaging (rs-fMRI) in infants enables important studies of functional brain organization early in human development. However, rs-fMRI in infants has universally been obtained during sleep to reduce participant motion artifact, raising the question of whether differences in functional organization between awake adults and sleeping infants that are commonly attributed to development may instead derive, at least in part, from sleep. This question is especially important as rs-fMRI differences in adult wake vs. sleep are well documented. To investigate this question, we compared functional connectivity and BOLD signal propagation patterns in 6, 12, and 24 month old sleeping infants with patterns in adult wakefulness and non-REM sleep. We find that important functional connectivity features seen during infant sleep closely resemble those seen during adult sleep, including reduced default mode network functional connectivity. However, we also find differences between infant and adult sleep, especially in thalamic BOLD signal propagation patterns. These findings highlight the importance of considering sleep state when drawing developmental inferences in infant rs-fMRI. © 2017 Mitra et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| title |
Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness |
| title_short |
Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness |
| title_full |
Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness |
| title_fullStr |
Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness |
| title_full_unstemmed |
Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness |
| title_sort |
resting-state fmri in sleeping infants more closely resembles adult sleep than adult wakefulness |
| publishDate |
2017 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19326203_v12_n11_p_Mitra http://hdl.handle.net/20.500.12110/paper_19326203_v12_n11_p_Mitra |
| _version_ |
1768542617457393664 |