Differential left hippocampal activation during retrieval with different types of reminders: An fMRI study of the reconsolidation process

Consolidated memories return to a labile state after the presentation of cues (reminders) associated with acquisition, followed by a period of stabilization (reconsolidation). However not all cues are equally effective in initiating the process, unpredictable cues triggered it, predictable cues do n...

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Autores principales:	Forcato, Cecilia, Bavassi, Mariana Luz, Pedreira, Maria Eugenia
Publicado:	2016
Materias:	comparative effectiveness controlled study functional magnetic resonance imaging hippocampus human information retrieval memory adolescent adult association female learning male non-therapeutic research nuclear magnetic resonance imaging physiology recall reminder system young adult Adolescent Adult Association Learning Cues Female Hippocampus Humans Magnetic Resonance Imaging Male Memory Mental Recall Nontherapeutic Human Experimentation Reminder Systems Young Adult
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19326203_v11_n3_p_Forcato http://hdl.handle.net/20.500.12110/paper_19326203_v11_n3_p_Forcato
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_19326203_v11_n3_p_Forcato
record_format	dspace
spelling	paper:paper_19326203_v11_n3_p_Forcato2023-06-08T16:30:34Z Differential left hippocampal activation during retrieval with different types of reminders: An fMRI study of the reconsolidation process Forcato, Cecilia Bavassi, Mariana Luz Pedreira, Maria Eugenia comparative effectiveness controlled study functional magnetic resonance imaging hippocampus human information retrieval memory adolescent adult association female hippocampus learning male non-therapeutic research nuclear magnetic resonance imaging physiology recall reminder system young adult Adolescent Adult Association Learning Cues Female Hippocampus Humans Magnetic Resonance Imaging Male Memory Mental Recall Nontherapeutic Human Experimentation Reminder Systems Young Adult Consolidated memories return to a labile state after the presentation of cues (reminders) associated with acquisition, followed by a period of stabilization (reconsolidation). However not all cues are equally effective in initiating the process, unpredictable cues triggered it, predictable cues do not. We hypothesize that the different effects observed by the different reminder types on memory labilization-reconsolidation depend on a differential neural involvement during reminder presentation. To test it, we developed a declarative task and compared the efficacy of three reminder types in triggering the process in humans (Experiment 1). Finally, we compared the brain activation patterns between the different conditions using functional magnetic resonance imaging (fMRI) (Experiment 2). We confirmed that the unpredictable reminder is the most effective in initiating the labilization-reconsolidation process. Furthermore, only under this condition there was differential left hippocampal activation during its presentation.We suggest that the left hippocampus is detecting the incongruence between actual and past events and allows the memory to be updated. © 2016 Forcato et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Fil:Forcato, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Bavassi, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Pedreira, M.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2016 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19326203_v11_n3_p_Forcato http://hdl.handle.net/20.500.12110/paper_19326203_v11_n3_p_Forcato
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	comparative effectiveness controlled study functional magnetic resonance imaging hippocampus human information retrieval memory adolescent adult association female hippocampus learning male non-therapeutic research nuclear magnetic resonance imaging physiology recall reminder system young adult Adolescent Adult Association Learning Cues Female Hippocampus Humans Magnetic Resonance Imaging Male Memory Mental Recall Nontherapeutic Human Experimentation Reminder Systems Young Adult
spellingShingle	comparative effectiveness controlled study functional magnetic resonance imaging hippocampus human information retrieval memory adolescent adult association female hippocampus learning male non-therapeutic research nuclear magnetic resonance imaging physiology recall reminder system young adult Adolescent Adult Association Learning Cues Female Hippocampus Humans Magnetic Resonance Imaging Male Memory Mental Recall Nontherapeutic Human Experimentation Reminder Systems Young Adult Forcato, Cecilia Bavassi, Mariana Luz Pedreira, Maria Eugenia Differential left hippocampal activation during retrieval with different types of reminders: An fMRI study of the reconsolidation process
topic_facet	comparative effectiveness controlled study functional magnetic resonance imaging hippocampus human information retrieval memory adolescent adult association female hippocampus learning male non-therapeutic research nuclear magnetic resonance imaging physiology recall reminder system young adult Adolescent Adult Association Learning Cues Female Hippocampus Humans Magnetic Resonance Imaging Male Memory Mental Recall Nontherapeutic Human Experimentation Reminder Systems Young Adult
description	Consolidated memories return to a labile state after the presentation of cues (reminders) associated with acquisition, followed by a period of stabilization (reconsolidation). However not all cues are equally effective in initiating the process, unpredictable cues triggered it, predictable cues do not. We hypothesize that the different effects observed by the different reminder types on memory labilization-reconsolidation depend on a differential neural involvement during reminder presentation. To test it, we developed a declarative task and compared the efficacy of three reminder types in triggering the process in humans (Experiment 1). Finally, we compared the brain activation patterns between the different conditions using functional magnetic resonance imaging (fMRI) (Experiment 2). We confirmed that the unpredictable reminder is the most effective in initiating the labilization-reconsolidation process. Furthermore, only under this condition there was differential left hippocampal activation during its presentation.We suggest that the left hippocampus is detecting the incongruence between actual and past events and allows the memory to be updated. © 2016 Forcato et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
author	Forcato, Cecilia Bavassi, Mariana Luz Pedreira, Maria Eugenia
author_facet	Forcato, Cecilia Bavassi, Mariana Luz Pedreira, Maria Eugenia
author_sort	Forcato, Cecilia
title	Differential left hippocampal activation during retrieval with different types of reminders: An fMRI study of the reconsolidation process
title_short	Differential left hippocampal activation during retrieval with different types of reminders: An fMRI study of the reconsolidation process
title_full	Differential left hippocampal activation during retrieval with different types of reminders: An fMRI study of the reconsolidation process
title_fullStr	Differential left hippocampal activation during retrieval with different types of reminders: An fMRI study of the reconsolidation process
title_full_unstemmed	Differential left hippocampal activation during retrieval with different types of reminders: An fMRI study of the reconsolidation process
title_sort	differential left hippocampal activation during retrieval with different types of reminders: an fmri study of the reconsolidation process
publishDate	2016
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19326203_v11_n3_p_Forcato http://hdl.handle.net/20.500.12110/paper_19326203_v11_n3_p_Forcato
work_keys_str_mv	AT forcatocecilia differentiallefthippocampalactivationduringretrievalwithdifferenttypesofremindersanfmristudyofthereconsolidationprocess AT bavassimarianaluz differentiallefthippocampalactivationduringretrievalwithdifferenttypesofremindersanfmristudyofthereconsolidationprocess AT pedreiramariaeugenia differentiallefthippocampalactivationduringretrievalwithdifferenttypesofremindersanfmristudyofthereconsolidationprocess
_version_	1768546418320998400

Differential left hippocampal activation during retrieval with different types of reminders: An fMRI study of the reconsolidation process

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