Overcrowding-mediated stress alters cell proliferation in key neuroendocrine areas during larval development in Rhinella arenarum
Exposure to adverse environmental conditions can elicit a stress response, which results in an increase in endogenous corticosterone levels. In early life stages, it has been thoroughly demonstrated that amphibian larval growth and development is altered as a consequence of chronic stress by interfe...
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paper:paper_19325223_v325_n2_p149_Distler2023-06-08T16:30:25Z Overcrowding-mediated stress alters cell proliferation in key neuroendocrine areas during larval development in Rhinella arenarum Jungblut, Lucas David Ceballos, Nora Raquel Paz, Dante Agustin Pozzi, Andrea Gabriela corticosterone animal apoptosis brain Bufo arenarum cell proliferation crowding (area) cytology growth, development and aging hypophysis larva metamorphosis neurosecretion physiological stress Animals Apoptosis Brain Bufo arenarum Cell Proliferation Corticosterone Crowding Larva Metamorphosis, Biological Neurosecretory Systems Pituitary Gland Stress, Physiological Exposure to adverse environmental conditions can elicit a stress response, which results in an increase in endogenous corticosterone levels. In early life stages, it has been thoroughly demonstrated that amphibian larval growth and development is altered as a consequence of chronic stress by interfering with the metamorphic process, however, the underlying mechanisms involved have only been partially disentangled. We examined the effect of intraspecific competition on corticosterone levels during larval development of the toad Rhinella arenarum and its ultimate effects on cell proliferation in particular brain areas as well as the pituitary gland. While overcrowding altered the number of proliferating cells in the pituitary gland, hypothalamus, and third ventricle of the brain, no differences were observed in areas which are less associated with neuroendocrine processes, such as the first ventricle of the brain. Apoptosis was increased in hypothalamic regions but not in the pituitary. With regards to pituitary cell populations, thyrotrophs but not somatoatrophs and corticotrophs showed a decrease in the cell number in overcrowded larvae. Our study shows that alterations in growth and development, produced by stress, results from an imbalance in the neuroendocrine systems implicated in orchestrating the timing of metamorphosis. © 2016 Wiley Periodicals, Inc. Fil:Jungblut, L.D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Ceballos, N.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Paz, D.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Pozzi, A.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2016 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19325223_v325_n2_p149_Distler http://hdl.handle.net/20.500.12110/paper_19325223_v325_n2_p149_Distler |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
corticosterone animal apoptosis brain Bufo arenarum cell proliferation crowding (area) cytology growth, development and aging hypophysis larva metamorphosis neurosecretion physiological stress Animals Apoptosis Brain Bufo arenarum Cell Proliferation Corticosterone Crowding Larva Metamorphosis, Biological Neurosecretory Systems Pituitary Gland Stress, Physiological |
| spellingShingle |
corticosterone animal apoptosis brain Bufo arenarum cell proliferation crowding (area) cytology growth, development and aging hypophysis larva metamorphosis neurosecretion physiological stress Animals Apoptosis Brain Bufo arenarum Cell Proliferation Corticosterone Crowding Larva Metamorphosis, Biological Neurosecretory Systems Pituitary Gland Stress, Physiological Jungblut, Lucas David Ceballos, Nora Raquel Paz, Dante Agustin Pozzi, Andrea Gabriela Overcrowding-mediated stress alters cell proliferation in key neuroendocrine areas during larval development in Rhinella arenarum |
| topic_facet |
corticosterone animal apoptosis brain Bufo arenarum cell proliferation crowding (area) cytology growth, development and aging hypophysis larva metamorphosis neurosecretion physiological stress Animals Apoptosis Brain Bufo arenarum Cell Proliferation Corticosterone Crowding Larva Metamorphosis, Biological Neurosecretory Systems Pituitary Gland Stress, Physiological |
| description |
Exposure to adverse environmental conditions can elicit a stress response, which results in an increase in endogenous corticosterone levels. In early life stages, it has been thoroughly demonstrated that amphibian larval growth and development is altered as a consequence of chronic stress by interfering with the metamorphic process, however, the underlying mechanisms involved have only been partially disentangled. We examined the effect of intraspecific competition on corticosterone levels during larval development of the toad Rhinella arenarum and its ultimate effects on cell proliferation in particular brain areas as well as the pituitary gland. While overcrowding altered the number of proliferating cells in the pituitary gland, hypothalamus, and third ventricle of the brain, no differences were observed in areas which are less associated with neuroendocrine processes, such as the first ventricle of the brain. Apoptosis was increased in hypothalamic regions but not in the pituitary. With regards to pituitary cell populations, thyrotrophs but not somatoatrophs and corticotrophs showed a decrease in the cell number in overcrowded larvae. Our study shows that alterations in growth and development, produced by stress, results from an imbalance in the neuroendocrine systems implicated in orchestrating the timing of metamorphosis. © 2016 Wiley Periodicals, Inc. |
| author |
Jungblut, Lucas David Ceballos, Nora Raquel Paz, Dante Agustin Pozzi, Andrea Gabriela |
| author_facet |
Jungblut, Lucas David Ceballos, Nora Raquel Paz, Dante Agustin Pozzi, Andrea Gabriela |
| author_sort |
Jungblut, Lucas David |
| title |
Overcrowding-mediated stress alters cell proliferation in key neuroendocrine areas during larval development in Rhinella arenarum |
| title_short |
Overcrowding-mediated stress alters cell proliferation in key neuroendocrine areas during larval development in Rhinella arenarum |
| title_full |
Overcrowding-mediated stress alters cell proliferation in key neuroendocrine areas during larval development in Rhinella arenarum |
| title_fullStr |
Overcrowding-mediated stress alters cell proliferation in key neuroendocrine areas during larval development in Rhinella arenarum |
| title_full_unstemmed |
Overcrowding-mediated stress alters cell proliferation in key neuroendocrine areas during larval development in Rhinella arenarum |
| title_sort |
overcrowding-mediated stress alters cell proliferation in key neuroendocrine areas during larval development in rhinella arenarum |
| publishDate |
2016 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19325223_v325_n2_p149_Distler http://hdl.handle.net/20.500.12110/paper_19325223_v325_n2_p149_Distler |
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| _version_ |
1768545576955150336 |