The interplay between the glucocorticoid receptor activity and post-translational modifications in the immune and neuroendocrine systems
Glucocorticoids (GCs), the most downstream effectors of the hypothalamic-pituitary-adrenal (HPA) axis, are key mediators in the interaction between immune and neuroendocrine systems. They exert their biological actions mainly through binding to their intracellular receptor, the glucocorticoid recept...
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1878948X_v5_n1_p19_AntunicaNoguerol http://hdl.handle.net/20.500.12110/paper_1878948X_v5_n1_p19_AntunicaNoguerol |
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paper:paper_1878948X_v5_n1_p19_AntunicaNoguerol2023-06-08T16:30:18Z The interplay between the glucocorticoid receptor activity and post-translational modifications in the immune and neuroendocrine systems Liberman, Ana Glucocorticoid receptor post-translational modifications transcription regulation glucocorticoid glucocorticoid receptor transcription factor allergic disease article autoimmune disease biological functions disease activity disease association disease course gene expression graft rejection hormone action hormone response human hypothalamus hypophysis adrenal system immunopathology inflammatory disease molecular biology neuroendocrine disease nonhuman outcome assessment pathophysiology priority journal protein defect protein function protein phosphorylation protein processing receptor binding signal transduction tissue specificity Glucocorticoids (GCs), the most downstream effectors of the hypothalamic-pituitary-adrenal (HPA) axis, are key mediators in the interaction between immune and neuroendocrine systems. They exert their biological actions mainly through binding to their intracellular receptor, the glucocorticoid receptor (GR), which in turn influences gene expression by interacting with transcription factors and/or coregulators. GR abnormal function has been extensively associated to stress-related disorders, inflammatory and autoimmune diseases. Therefore, modulating GR activity is critical to overcome pathological conditions. The final outcome of GCs actions in the immune and neuroendocrine systems is regulated at multiple levels, including post-translational modifications (PTMs) of GR as well as of protein complexes involved in GR signaling. Understanding the influence of PTMs on the molecular mechanisms involved in GR signaling is thus of utmost importance in the search for therapeutic strategies aimed at modulating GR responses under pathophysiological circumstances, and to understand the neuroimmune circuits. © 2014 - IOS Press. Fil:Liberman, A.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2014 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1878948X_v5_n1_p19_AntunicaNoguerol http://hdl.handle.net/20.500.12110/paper_1878948X_v5_n1_p19_AntunicaNoguerol |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Glucocorticoid receptor post-translational modifications transcription regulation glucocorticoid glucocorticoid receptor transcription factor allergic disease article autoimmune disease biological functions disease activity disease association disease course gene expression graft rejection hormone action hormone response human hypothalamus hypophysis adrenal system immunopathology inflammatory disease molecular biology neuroendocrine disease nonhuman outcome assessment pathophysiology priority journal protein defect protein function protein phosphorylation protein processing receptor binding signal transduction tissue specificity |
| spellingShingle |
Glucocorticoid receptor post-translational modifications transcription regulation glucocorticoid glucocorticoid receptor transcription factor allergic disease article autoimmune disease biological functions disease activity disease association disease course gene expression graft rejection hormone action hormone response human hypothalamus hypophysis adrenal system immunopathology inflammatory disease molecular biology neuroendocrine disease nonhuman outcome assessment pathophysiology priority journal protein defect protein function protein phosphorylation protein processing receptor binding signal transduction tissue specificity Liberman, Ana The interplay between the glucocorticoid receptor activity and post-translational modifications in the immune and neuroendocrine systems |
| topic_facet |
Glucocorticoid receptor post-translational modifications transcription regulation glucocorticoid glucocorticoid receptor transcription factor allergic disease article autoimmune disease biological functions disease activity disease association disease course gene expression graft rejection hormone action hormone response human hypothalamus hypophysis adrenal system immunopathology inflammatory disease molecular biology neuroendocrine disease nonhuman outcome assessment pathophysiology priority journal protein defect protein function protein phosphorylation protein processing receptor binding signal transduction tissue specificity |
| description |
Glucocorticoids (GCs), the most downstream effectors of the hypothalamic-pituitary-adrenal (HPA) axis, are key mediators in the interaction between immune and neuroendocrine systems. They exert their biological actions mainly through binding to their intracellular receptor, the glucocorticoid receptor (GR), which in turn influences gene expression by interacting with transcription factors and/or coregulators. GR abnormal function has been extensively associated to stress-related disorders, inflammatory and autoimmune diseases. Therefore, modulating GR activity is critical to overcome pathological conditions. The final outcome of GCs actions in the immune and neuroendocrine systems is regulated at multiple levels, including post-translational modifications (PTMs) of GR as well as of protein complexes involved in GR signaling. Understanding the influence of PTMs on the molecular mechanisms involved in GR signaling is thus of utmost importance in the search for therapeutic strategies aimed at modulating GR responses under pathophysiological circumstances, and to understand the neuroimmune circuits. © 2014 - IOS Press. |
| author |
Liberman, Ana |
| author_facet |
Liberman, Ana |
| author_sort |
Liberman, Ana |
| title |
The interplay between the glucocorticoid receptor activity and post-translational modifications in the immune and neuroendocrine systems |
| title_short |
The interplay between the glucocorticoid receptor activity and post-translational modifications in the immune and neuroendocrine systems |
| title_full |
The interplay between the glucocorticoid receptor activity and post-translational modifications in the immune and neuroendocrine systems |
| title_fullStr |
The interplay between the glucocorticoid receptor activity and post-translational modifications in the immune and neuroendocrine systems |
| title_full_unstemmed |
The interplay between the glucocorticoid receptor activity and post-translational modifications in the immune and neuroendocrine systems |
| title_sort |
interplay between the glucocorticoid receptor activity and post-translational modifications in the immune and neuroendocrine systems |
| publishDate |
2014 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1878948X_v5_n1_p19_AntunicaNoguerol http://hdl.handle.net/20.500.12110/paper_1878948X_v5_n1_p19_AntunicaNoguerol |
| work_keys_str_mv |
AT libermanana theinterplaybetweentheglucocorticoidreceptoractivityandposttranslationalmodificationsintheimmuneandneuroendocrinesystems AT libermanana interplaybetweentheglucocorticoidreceptoractivityandposttranslationalmodificationsintheimmuneandneuroendocrinesystems |
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1768546273630093312 |