Modelling American Trypanosomiasis in an Endemic Zone: Application to the Initial Spread of Household Infection in the Argentine Chaco
Summary: The complex dynamics of Trypanosoma cruzi infection (Chagas disease) involves different actors and multiple transmission routes. Based on the information currently available, here, we propose a new and more comprehensive model to better understand the dynamics of the infection. This mathema...
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paper:paper_18631959_v61_n8_p545_Fabrizio2023-06-08T16:29:34Z Modelling American Trypanosomiasis in an Endemic Zone: Application to the Initial Spread of Household Infection in the Argentine Chaco Fabrizio, María del Carmen Schweigmann, Nicolás Joaquin Dogs Household infection Mathematical model Triatomines Trypanosoma cruzi infection Argentina Article birth rate disease model disease transmission feeding behavior fertility household human mathematical analysis mathematical model nonhuman prediction seroprevalence simulation trypanosomiasis validation process animal Chagas disease computer simulation disease carrier dog Dog Diseases incidence parasitology physiology rural population theoretical model transmission Triatominae Trypanosoma cruzi zoonosis Canis familiaris Trypanosoma cruzi Animals Argentina Chagas Disease Computer Simulation Dog Diseases Dogs Humans Incidence Insect Vectors Models, Theoretical Rural Population Triatominae Trypanosoma cruzi Zoonoses Summary: The complex dynamics of Trypanosoma cruzi infection (Chagas disease) involves different actors and multiple transmission routes. Based on the information currently available, here, we propose a new and more comprehensive model to better understand the dynamics of the infection. This mathematical deterministic model was formulated considering: (i) the three clinical forms in humans: acute, chronic indeterminate and chronic with determinate pathology, (ii) the three main modes of transmission in the human population: vector-borne, congenital and transfusional, (iii) populations of triatomines and dogs as the main domestic reservoirs of T. cruzi and (iv) open populations. A numerical simulation was also performed to estimate the initial spread of the infection in a typical rural household in the endemic zone of the Argentine Gran Chaco. We also analysed the incidence of infected individuals corresponding to each of the three species (humans/triatomines/dogs) over times until the appearance of the first case in the other species. The model predicts that, in the absence of control measures, a few infected individuals are sufficient for the establishment and dispersion of the infection in all the inhabitants of the household. The model proposed and the results obtained allow describing the consequences of the presence of infected individuals in any of the three species considered in the dynamics and the output of the infection. © 2014 Blackwell Verlag GmbH. Fil:Fabrizio, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Schweigmann, N.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2014 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18631959_v61_n8_p545_Fabrizio http://hdl.handle.net/20.500.12110/paper_18631959_v61_n8_p545_Fabrizio |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Dogs Household infection Mathematical model Triatomines Trypanosoma cruzi infection Argentina Article birth rate disease model disease transmission feeding behavior fertility household human mathematical analysis mathematical model nonhuman prediction seroprevalence simulation trypanosomiasis validation process animal Chagas disease computer simulation disease carrier dog Dog Diseases incidence parasitology physiology rural population theoretical model transmission Triatominae Trypanosoma cruzi zoonosis Canis familiaris Trypanosoma cruzi Animals Argentina Chagas Disease Computer Simulation Dog Diseases Dogs Humans Incidence Insect Vectors Models, Theoretical Rural Population Triatominae Trypanosoma cruzi Zoonoses |
| spellingShingle |
Dogs Household infection Mathematical model Triatomines Trypanosoma cruzi infection Argentina Article birth rate disease model disease transmission feeding behavior fertility household human mathematical analysis mathematical model nonhuman prediction seroprevalence simulation trypanosomiasis validation process animal Chagas disease computer simulation disease carrier dog Dog Diseases incidence parasitology physiology rural population theoretical model transmission Triatominae Trypanosoma cruzi zoonosis Canis familiaris Trypanosoma cruzi Animals Argentina Chagas Disease Computer Simulation Dog Diseases Dogs Humans Incidence Insect Vectors Models, Theoretical Rural Population Triatominae Trypanosoma cruzi Zoonoses Fabrizio, María del Carmen Schweigmann, Nicolás Joaquin Modelling American Trypanosomiasis in an Endemic Zone: Application to the Initial Spread of Household Infection in the Argentine Chaco |
| topic_facet |
Dogs Household infection Mathematical model Triatomines Trypanosoma cruzi infection Argentina Article birth rate disease model disease transmission feeding behavior fertility household human mathematical analysis mathematical model nonhuman prediction seroprevalence simulation trypanosomiasis validation process animal Chagas disease computer simulation disease carrier dog Dog Diseases incidence parasitology physiology rural population theoretical model transmission Triatominae Trypanosoma cruzi zoonosis Canis familiaris Trypanosoma cruzi Animals Argentina Chagas Disease Computer Simulation Dog Diseases Dogs Humans Incidence Insect Vectors Models, Theoretical Rural Population Triatominae Trypanosoma cruzi Zoonoses |
| description |
Summary: The complex dynamics of Trypanosoma cruzi infection (Chagas disease) involves different actors and multiple transmission routes. Based on the information currently available, here, we propose a new and more comprehensive model to better understand the dynamics of the infection. This mathematical deterministic model was formulated considering: (i) the three clinical forms in humans: acute, chronic indeterminate and chronic with determinate pathology, (ii) the three main modes of transmission in the human population: vector-borne, congenital and transfusional, (iii) populations of triatomines and dogs as the main domestic reservoirs of T. cruzi and (iv) open populations. A numerical simulation was also performed to estimate the initial spread of the infection in a typical rural household in the endemic zone of the Argentine Gran Chaco. We also analysed the incidence of infected individuals corresponding to each of the three species (humans/triatomines/dogs) over times until the appearance of the first case in the other species. The model predicts that, in the absence of control measures, a few infected individuals are sufficient for the establishment and dispersion of the infection in all the inhabitants of the household. The model proposed and the results obtained allow describing the consequences of the presence of infected individuals in any of the three species considered in the dynamics and the output of the infection. © 2014 Blackwell Verlag GmbH. |
| author |
Fabrizio, María del Carmen Schweigmann, Nicolás Joaquin |
| author_facet |
Fabrizio, María del Carmen Schweigmann, Nicolás Joaquin |
| author_sort |
Fabrizio, María del Carmen |
| title |
Modelling American Trypanosomiasis in an Endemic Zone: Application to the Initial Spread of Household Infection in the Argentine Chaco |
| title_short |
Modelling American Trypanosomiasis in an Endemic Zone: Application to the Initial Spread of Household Infection in the Argentine Chaco |
| title_full |
Modelling American Trypanosomiasis in an Endemic Zone: Application to the Initial Spread of Household Infection in the Argentine Chaco |
| title_fullStr |
Modelling American Trypanosomiasis in an Endemic Zone: Application to the Initial Spread of Household Infection in the Argentine Chaco |
| title_full_unstemmed |
Modelling American Trypanosomiasis in an Endemic Zone: Application to the Initial Spread of Household Infection in the Argentine Chaco |
| title_sort |
modelling american trypanosomiasis in an endemic zone: application to the initial spread of household infection in the argentine chaco |
| publishDate |
2014 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18631959_v61_n8_p545_Fabrizio http://hdl.handle.net/20.500.12110/paper_18631959_v61_n8_p545_Fabrizio |
| work_keys_str_mv |
AT fabriziomariadelcarmen modellingamericantrypanosomiasisinanendemiczoneapplicationtotheinitialspreadofhouseholdinfectionintheargentinechaco AT schweigmannnicolasjoaquin modellingamericantrypanosomiasisinanendemiczoneapplicationtotheinitialspreadofhouseholdinfectionintheargentinechaco |
| _version_ |
1768544705774092288 |