Mean field strategies induce unrealistic non-linearities in calcium puffs

Mean field models are often useful approximations to biological systems, but sometimes, they can yield misleading results. In this work, we compare mean field approaches with stochastic models of intracellular calcium release. In particular, we concentrate on calcium signals generated by the concert...

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Autores principales: Solovey, Guillermo, Ponce Dawson, Silvina
Publicado: 2011
Materias:
Calcium signals
Mean field model
Puffs
Stochastic model
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1664042X_v2AUG_n_p_Solovey
http://hdl.handle.net/20.500.12110/paper_1664042X_v2AUG_n_p_Solovey
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_1664042X_v2AUG_n_p_Solovey
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spelling paper:paper_1664042X_v2AUG_n_p_Solovey2023-06-08T16:25:55Z Mean field strategies induce unrealistic non-linearities in calcium puffs Solovey, Guillermo Ponce Dawson, Silvina Calcium signals Mean field model Puffs Stochastic model Mean field models are often useful approximations to biological systems, but sometimes, they can yield misleading results. In this work, we compare mean field approaches with stochastic models of intracellular calcium release. In particular, we concentrate on calcium signals generated by the concerted opening of several clustered channels (calcium puffs). To this end we simulate calcium puffs numerically and then try to reproduce features of the resulting calcium distribution using mean field models were all the channels open and close simultaneously. We show that an unrealistic non-linear relationship between the current and the number of open channels is needed to reproduce the simulated puffs. Furthermore, a single channel current which is five times smaller than the one of the stochastic simulations is also needed. Our study sheds light on the importance of the stochastic kinetics of the calcium release channel activity to estimate the release fluxes. © 2011 Solovey, Fraiman and Dawson. Fil:Solovey, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Dawson, S.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2011 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1664042X_v2AUG_n_p_Solovey http://hdl.handle.net/20.500.12110/paper_1664042X_v2AUG_n_p_Solovey
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Calcium signals
Mean field model
Puffs
Stochastic model
spellingShingle Calcium signals
Mean field model
Puffs
Stochastic model
Solovey, Guillermo
Ponce Dawson, Silvina
Mean field strategies induce unrealistic non-linearities in calcium puffs
topic_facet Calcium signals
Mean field model
Puffs
Stochastic model
description Mean field models are often useful approximations to biological systems, but sometimes, they can yield misleading results. In this work, we compare mean field approaches with stochastic models of intracellular calcium release. In particular, we concentrate on calcium signals generated by the concerted opening of several clustered channels (calcium puffs). To this end we simulate calcium puffs numerically and then try to reproduce features of the resulting calcium distribution using mean field models were all the channels open and close simultaneously. We show that an unrealistic non-linear relationship between the current and the number of open channels is needed to reproduce the simulated puffs. Furthermore, a single channel current which is five times smaller than the one of the stochastic simulations is also needed. Our study sheds light on the importance of the stochastic kinetics of the calcium release channel activity to estimate the release fluxes. © 2011 Solovey, Fraiman and Dawson.
author Solovey, Guillermo
Ponce Dawson, Silvina
author_facet Solovey, Guillermo
Ponce Dawson, Silvina
author_sort Solovey, Guillermo
title Mean field strategies induce unrealistic non-linearities in calcium puffs
title_short Mean field strategies induce unrealistic non-linearities in calcium puffs
title_full Mean field strategies induce unrealistic non-linearities in calcium puffs
title_fullStr Mean field strategies induce unrealistic non-linearities in calcium puffs
title_full_unstemmed Mean field strategies induce unrealistic non-linearities in calcium puffs
title_sort mean field strategies induce unrealistic non-linearities in calcium puffs
publishDate 2011
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1664042X_v2AUG_n_p_Solovey
http://hdl.handle.net/20.500.12110/paper_1664042X_v2AUG_n_p_Solovey
work_keys_str_mv AT soloveyguillermo meanfieldstrategiesinduceunrealisticnonlinearitiesincalciumpuffs
AT poncedawsonsilvina meanfieldstrategiesinduceunrealisticnonlinearitiesincalciumpuffs
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