NF-κB transcription factor role in consolidation and reconsolidation of persistent memories
Transcriptional regulation is an important molecular process required for long-term neural plasticity and long-term memory (LTM) formation. Thus, one main interest in molecular neuroscience in the last decades has been the identification of transcription factors that are involved in memory processes...
Guardado en:
| Publicado: |
2015
|
|---|---|
| Materias: | |
| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16625099_v8_nSeptember_p_delaFuente http://hdl.handle.net/20.500.12110/paper_16625099_v8_nSeptember_p_delaFuente |
| Aporte de: |
| id |
paper:paper_16625099_v8_nSeptember_p_delaFuente |
|---|---|
| record_format |
dspace |
| spelling |
paper:paper_16625099_v8_nSeptember_p_delaFuente2023-06-08T16:25:46Z NF-κB transcription factor role in consolidation and reconsolidation of persistent memories Consolidation Memory NF-κB Reconsolidation Transcription factors cyclic AMP responsive element binding protein binding protein immunoglobulin enhancer binding protein oligodeoxynucleotide transcription factor transcription factor Zif 268 unclassified drug amygdaloid nucleus Article central nervous system conditioning epigenetics fear hippocampus histone acetylation knockout mouse learning long term memory memory consolidation memory reconsolidation nerve cell plasticity nonhuman novel object recognition test place preference protein phosphorylation recall stimulus response task performance transcription regulation Transcriptional regulation is an important molecular process required for long-term neural plasticity and long-term memory (LTM) formation. Thus, one main interest in molecular neuroscience in the last decades has been the identification of transcription factors that are involved in memory processes. Among them, the nuclear factor κB (NF-κB) family of transcription factors has gained interest due to a significant body of evidence that supports a key role of these proteins in synaptic plasticity and memory. In recent years, the interest was particularly reinforced because NF-κB was characterized as an important regulator of synaptogenesis. This function may be explained by its participation in synapse to nucleus communication, as well as a possible local role at the synapse. This review provides an overview of experimental work obtained in the last years, showing the essential role of this transcription factor in memory processes in different learning tasks in mammals. We focus the review on the consolidation and reconsolidation memory phases as well as on the regulation of immediate-early and late genes by epigenetic mechanisms that determine enduring forms of memories. © 2015 de la Fuente, Federman, Zalcman, Salles, Freudenthal and Romano. 2015 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16625099_v8_nSeptember_p_delaFuente http://hdl.handle.net/20.500.12110/paper_16625099_v8_nSeptember_p_delaFuente |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Consolidation Memory NF-κB Reconsolidation Transcription factors cyclic AMP responsive element binding protein binding protein immunoglobulin enhancer binding protein oligodeoxynucleotide transcription factor transcription factor Zif 268 unclassified drug amygdaloid nucleus Article central nervous system conditioning epigenetics fear hippocampus histone acetylation knockout mouse learning long term memory memory consolidation memory reconsolidation nerve cell plasticity nonhuman novel object recognition test place preference protein phosphorylation recall stimulus response task performance transcription regulation |
| spellingShingle |
Consolidation Memory NF-κB Reconsolidation Transcription factors cyclic AMP responsive element binding protein binding protein immunoglobulin enhancer binding protein oligodeoxynucleotide transcription factor transcription factor Zif 268 unclassified drug amygdaloid nucleus Article central nervous system conditioning epigenetics fear hippocampus histone acetylation knockout mouse learning long term memory memory consolidation memory reconsolidation nerve cell plasticity nonhuman novel object recognition test place preference protein phosphorylation recall stimulus response task performance transcription regulation NF-κB transcription factor role in consolidation and reconsolidation of persistent memories |
| topic_facet |
Consolidation Memory NF-κB Reconsolidation Transcription factors cyclic AMP responsive element binding protein binding protein immunoglobulin enhancer binding protein oligodeoxynucleotide transcription factor transcription factor Zif 268 unclassified drug amygdaloid nucleus Article central nervous system conditioning epigenetics fear hippocampus histone acetylation knockout mouse learning long term memory memory consolidation memory reconsolidation nerve cell plasticity nonhuman novel object recognition test place preference protein phosphorylation recall stimulus response task performance transcription regulation |
| description |
Transcriptional regulation is an important molecular process required for long-term neural plasticity and long-term memory (LTM) formation. Thus, one main interest in molecular neuroscience in the last decades has been the identification of transcription factors that are involved in memory processes. Among them, the nuclear factor κB (NF-κB) family of transcription factors has gained interest due to a significant body of evidence that supports a key role of these proteins in synaptic plasticity and memory. In recent years, the interest was particularly reinforced because NF-κB was characterized as an important regulator of synaptogenesis. This function may be explained by its participation in synapse to nucleus communication, as well as a possible local role at the synapse. This review provides an overview of experimental work obtained in the last years, showing the essential role of this transcription factor in memory processes in different learning tasks in mammals. We focus the review on the consolidation and reconsolidation memory phases as well as on the regulation of immediate-early and late genes by epigenetic mechanisms that determine enduring forms of memories. © 2015 de la Fuente, Federman, Zalcman, Salles, Freudenthal and Romano. |
| title |
NF-κB transcription factor role in consolidation and reconsolidation of persistent memories |
| title_short |
NF-κB transcription factor role in consolidation and reconsolidation of persistent memories |
| title_full |
NF-κB transcription factor role in consolidation and reconsolidation of persistent memories |
| title_fullStr |
NF-κB transcription factor role in consolidation and reconsolidation of persistent memories |
| title_full_unstemmed |
NF-κB transcription factor role in consolidation and reconsolidation of persistent memories |
| title_sort |
nf-κb transcription factor role in consolidation and reconsolidation of persistent memories |
| publishDate |
2015 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16625099_v8_nSeptember_p_delaFuente http://hdl.handle.net/20.500.12110/paper_16625099_v8_nSeptember_p_delaFuente |
| _version_ |
1768542663949156352 |