CaMKII isoforms in learning and memory: Localization and function
Calcium/calmodulin-dependent protein kinase II (CaMKII) is a key protein kinase in neural plasticity and memory, as have been shown in several studies since the first evidence in long-term potentiation (LTP) 30 years ago. However, most of the studies were focused mainly in one of the four isoforms o...
Guardado en:
Publicado: |
2018
|
---|---|
Materias: | |
Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16625099_v11_n_p_Zalcman http://hdl.handle.net/20.500.12110/paper_16625099_v11_n_p_Zalcman |
Aporte de: |
id |
paper:paper_16625099_v11_n_p_Zalcman |
---|---|
record_format |
dspace |
spelling |
paper:paper_16625099_v11_n_p_Zalcman2023-06-08T16:25:46Z CaMKII isoforms in learning and memory: Localization and function CaMKII CaMKIIα CaMKIIβ CaMKIIγ CaMKIIδ Learning Memory calcium calmodulin dependent protein kinase II calcium calmodulin dependent protein kinase II alpha calcium calmodulin dependent protein kinase II beta calcium calmodulin dependent protein kinase II delta calcium calmodulin dependent protein kinase II gamma isoprotein n methyl dextro aspartic acid receptor unclassified drug autophosphorylation brain injury calcium signaling cell migration gene expression glutamatergic synapse human learning learning disorder long term potentiation memory nerve cell plasticity nerve growth neurite outgrowth neurotransmitter release nonhuman protein expression protein phosphorylation protein processing regulatory mechanism reperfusion injury Review signal transduction spatial memory Calcium/calmodulin-dependent protein kinase II (CaMKII) is a key protein kinase in neural plasticity and memory, as have been shown in several studies since the first evidence in long-term potentiation (LTP) 30 years ago. However, most of the studies were focused mainly in one of the four isoforms of this protein kinase, the CaMKIIα. Here we review the characteristics and the role of each of the four isoforms in learning, memory and neural plasticity, considering the well known local role of α and β isoforms in dendritic terminals as well as recent findings about the γ isoform as calcium signals transducers from synapse to nucleus and δ isoform as a kinase required for a more persistent memory trace. © 2018 Zalcman, Federman and Romano. 2018 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16625099_v11_n_p_Zalcman http://hdl.handle.net/20.500.12110/paper_16625099_v11_n_p_Zalcman |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
CaMKII CaMKIIα CaMKIIβ CaMKIIγ CaMKIIδ Learning Memory calcium calmodulin dependent protein kinase II calcium calmodulin dependent protein kinase II alpha calcium calmodulin dependent protein kinase II beta calcium calmodulin dependent protein kinase II delta calcium calmodulin dependent protein kinase II gamma isoprotein n methyl dextro aspartic acid receptor unclassified drug autophosphorylation brain injury calcium signaling cell migration gene expression glutamatergic synapse human learning learning disorder long term potentiation memory nerve cell plasticity nerve growth neurite outgrowth neurotransmitter release nonhuman protein expression protein phosphorylation protein processing regulatory mechanism reperfusion injury Review signal transduction spatial memory |
spellingShingle |
CaMKII CaMKIIα CaMKIIβ CaMKIIγ CaMKIIδ Learning Memory calcium calmodulin dependent protein kinase II calcium calmodulin dependent protein kinase II alpha calcium calmodulin dependent protein kinase II beta calcium calmodulin dependent protein kinase II delta calcium calmodulin dependent protein kinase II gamma isoprotein n methyl dextro aspartic acid receptor unclassified drug autophosphorylation brain injury calcium signaling cell migration gene expression glutamatergic synapse human learning learning disorder long term potentiation memory nerve cell plasticity nerve growth neurite outgrowth neurotransmitter release nonhuman protein expression protein phosphorylation protein processing regulatory mechanism reperfusion injury Review signal transduction spatial memory CaMKII isoforms in learning and memory: Localization and function |
topic_facet |
CaMKII CaMKIIα CaMKIIβ CaMKIIγ CaMKIIδ Learning Memory calcium calmodulin dependent protein kinase II calcium calmodulin dependent protein kinase II alpha calcium calmodulin dependent protein kinase II beta calcium calmodulin dependent protein kinase II delta calcium calmodulin dependent protein kinase II gamma isoprotein n methyl dextro aspartic acid receptor unclassified drug autophosphorylation brain injury calcium signaling cell migration gene expression glutamatergic synapse human learning learning disorder long term potentiation memory nerve cell plasticity nerve growth neurite outgrowth neurotransmitter release nonhuman protein expression protein phosphorylation protein processing regulatory mechanism reperfusion injury Review signal transduction spatial memory |
description |
Calcium/calmodulin-dependent protein kinase II (CaMKII) is a key protein kinase in neural plasticity and memory, as have been shown in several studies since the first evidence in long-term potentiation (LTP) 30 years ago. However, most of the studies were focused mainly in one of the four isoforms of this protein kinase, the CaMKIIα. Here we review the characteristics and the role of each of the four isoforms in learning, memory and neural plasticity, considering the well known local role of α and β isoforms in dendritic terminals as well as recent findings about the γ isoform as calcium signals transducers from synapse to nucleus and δ isoform as a kinase required for a more persistent memory trace. © 2018 Zalcman, Federman and Romano. |
title |
CaMKII isoforms in learning and memory: Localization and function |
title_short |
CaMKII isoforms in learning and memory: Localization and function |
title_full |
CaMKII isoforms in learning and memory: Localization and function |
title_fullStr |
CaMKII isoforms in learning and memory: Localization and function |
title_full_unstemmed |
CaMKII isoforms in learning and memory: Localization and function |
title_sort |
camkii isoforms in learning and memory: localization and function |
publishDate |
2018 |
url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_16625099_v11_n_p_Zalcman http://hdl.handle.net/20.500.12110/paper_16625099_v11_n_p_Zalcman |
_version_ |
1768546041277186048 |