Intragenic chromatin modifications: A new layer in alternative splicing regulation

The multiple steps that contribute to gene expression in the metazoan but in theory does not necessarily imply coupling of transcription with process-nucleus are highly integrated and regulated. Most of pre-mRNA processing is believed to occur co-transcriptionally and choices regarding alternative p...

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Publicado:	2010
Materias:	Alternative splicing Histone modifications Intragenic chromatin Noncoding RNA Nucleosome positioning SiRNA Transcription Transcriptional gene silencing double stranded RNA messenger RNA chromatin small interfering RNA alternative RNA splicing article cell nucleus chromatin assembly and disassembly depolarization DNA modification DNA sequence exon gene expression gene targeting metazoon nerve cell nonhuman nucleosome RNA processing RNA splicing RNA transcription Adenoviridae animal genetics human metabolism transcription elongation Metazoa Alternative Splicing Animals Chromatin Chromatin Assembly and Disassembly Humans RNA, Small Interfering Transcription Elongation, Genetic
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15592294_v5_n3_p174_Schor http://hdl.handle.net/20.500.12110/paper_15592294_v5_n3_p174_Schor
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_15592294_v5_n3_p174_Schor
record_format	dspace
spelling	paper:paper_15592294_v5_n3_p174_Schor2023-06-08T16:23:43Z Intragenic chromatin modifications: A new layer in alternative splicing regulation Alternative splicing Histone modifications Intragenic chromatin Noncoding RNA Nucleosome positioning SiRNA Transcription Transcriptional gene silencing double stranded RNA messenger RNA chromatin small interfering RNA alternative RNA splicing article cell nucleus chromatin chromatin assembly and disassembly depolarization DNA modification DNA sequence exon gene expression gene targeting metazoon nerve cell nonhuman nucleosome RNA processing RNA splicing RNA transcription Adenoviridae animal chromatin chromatin assembly and disassembly genetics human metabolism transcription elongation Metazoa Adenoviridae Alternative Splicing Animals Chromatin Chromatin Assembly and Disassembly Humans RNA, Small Interfering Transcription Elongation, Genetic The multiple steps that contribute to gene expression in the metazoan but in theory does not necessarily imply coupling of transcription with process-nucleus are highly integrated and regulated. Most of pre-mRNA processing is believed to occur co-transcriptionally and choices regarding alternative processing reactions are influenced by transcription. Several articles published in the last year unveiled a connection between chromatin structure and the splicing process, strengthening a view in which the dynamic of intragenic chromatin modifications has an important role regulating alternative splicing (AS) choices. We have recently shown that both neuronal cell depolarization and the use of double stranded small RNAs targeting intragenic regions can modulate AS through chromatin remodeling, taking advantage of the kinetic coupling between splicing and transcription. Here, we discuss the many ways in which intragenic chromatin can participate in alternative splicing regulation. © 2010 Landes Bioscience. 2010 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15592294_v5_n3_p174_Schor http://hdl.handle.net/20.500.12110/paper_15592294_v5_n3_p174_Schor
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Alternative splicing Histone modifications Intragenic chromatin Noncoding RNA Nucleosome positioning SiRNA Transcription Transcriptional gene silencing double stranded RNA messenger RNA chromatin small interfering RNA alternative RNA splicing article cell nucleus chromatin chromatin assembly and disassembly depolarization DNA modification DNA sequence exon gene expression gene targeting metazoon nerve cell nonhuman nucleosome RNA processing RNA splicing RNA transcription Adenoviridae animal chromatin chromatin assembly and disassembly genetics human metabolism transcription elongation Metazoa Adenoviridae Alternative Splicing Animals Chromatin Chromatin Assembly and Disassembly Humans RNA, Small Interfering Transcription Elongation, Genetic
spellingShingle	Alternative splicing Histone modifications Intragenic chromatin Noncoding RNA Nucleosome positioning SiRNA Transcription Transcriptional gene silencing double stranded RNA messenger RNA chromatin small interfering RNA alternative RNA splicing article cell nucleus chromatin chromatin assembly and disassembly depolarization DNA modification DNA sequence exon gene expression gene targeting metazoon nerve cell nonhuman nucleosome RNA processing RNA splicing RNA transcription Adenoviridae animal chromatin chromatin assembly and disassembly genetics human metabolism transcription elongation Metazoa Adenoviridae Alternative Splicing Animals Chromatin Chromatin Assembly and Disassembly Humans RNA, Small Interfering Transcription Elongation, Genetic Intragenic chromatin modifications: A new layer in alternative splicing regulation
topic_facet	Alternative splicing Histone modifications Intragenic chromatin Noncoding RNA Nucleosome positioning SiRNA Transcription Transcriptional gene silencing double stranded RNA messenger RNA chromatin small interfering RNA alternative RNA splicing article cell nucleus chromatin chromatin assembly and disassembly depolarization DNA modification DNA sequence exon gene expression gene targeting metazoon nerve cell nonhuman nucleosome RNA processing RNA splicing RNA transcription Adenoviridae animal chromatin chromatin assembly and disassembly genetics human metabolism transcription elongation Metazoa Adenoviridae Alternative Splicing Animals Chromatin Chromatin Assembly and Disassembly Humans RNA, Small Interfering Transcription Elongation, Genetic
description	The multiple steps that contribute to gene expression in the metazoan but in theory does not necessarily imply coupling of transcription with process-nucleus are highly integrated and regulated. Most of pre-mRNA processing is believed to occur co-transcriptionally and choices regarding alternative processing reactions are influenced by transcription. Several articles published in the last year unveiled a connection between chromatin structure and the splicing process, strengthening a view in which the dynamic of intragenic chromatin modifications has an important role regulating alternative splicing (AS) choices. We have recently shown that both neuronal cell depolarization and the use of double stranded small RNAs targeting intragenic regions can modulate AS through chromatin remodeling, taking advantage of the kinetic coupling between splicing and transcription. Here, we discuss the many ways in which intragenic chromatin can participate in alternative splicing regulation. © 2010 Landes Bioscience.
title	Intragenic chromatin modifications: A new layer in alternative splicing regulation
title_short	Intragenic chromatin modifications: A new layer in alternative splicing regulation
title_full	Intragenic chromatin modifications: A new layer in alternative splicing regulation
title_fullStr	Intragenic chromatin modifications: A new layer in alternative splicing regulation
title_full_unstemmed	Intragenic chromatin modifications: A new layer in alternative splicing regulation
title_sort	intragenic chromatin modifications: a new layer in alternative splicing regulation
publishDate	2010
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15592294_v5_n3_p174_Schor http://hdl.handle.net/20.500.12110/paper_15592294_v5_n3_p174_Schor
_version_	1768542100157104128

Intragenic chromatin modifications: A new layer in alternative splicing regulation

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