Alternative splicing at the right time
Alternative splicing (AS) allows the production of multiple mRNA variants from a single gene, which contributes to increase the complexity of the proteome. There is evidence that AS is regulated not only by auxiliary splicing factors, but also by components of the core spliceosomal machinery, as wel...
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2011
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Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15476286_v8_n6_p_Sanchez http://hdl.handle.net/20.500.12110/paper_15476286_v8_n6_p_Sanchez |
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paper:paper_15476286_v8_n6_p_Sanchez2023-06-08T16:21:20Z Alternative splicing at the right time Sanchez, Sabrina Elena Petrillo, Ezequiel Kornblihtt, Alberto Rodolfo Yanovsky, Marcelo Javier Alternative splicing Arabidopsis thaliana Circadian clock PRMT5 Transcriptional and post-transcriptional regulation messenger RNA protein arginine methyltransferase protein arginine methyltransferase 5 proteome unclassified drug Arabidopsis protein Dart5 protein, Drosophila Drosophila protein PRMT5 protein, Arabidopsis protein arginine methyltransferase protein methyltransferase alternative RNA splicing circadian rhythm epigenetics genetic variability nonhuman note oscillation regulatory mechanism spliceosome stimulus response animal Arabidopsis biological model circadian rhythm Drosophila melanogaster enzymology genetics metabolism review Arabidopsis thaliana Alternative Splicing Animals Arabidopsis Arabidopsis Proteins Circadian Clocks Drosophila melanogaster Drosophila Proteins Models, Genetic Protein Methyltransferases Protein-Arginine N-Methyltransferases Alternative splicing (AS) allows the production of multiple mRNA variants from a single gene, which contributes to increase the complexity of the proteome. There is evidence that AS is regulated not only by auxiliary splicing factors, but also by components of the core spliceosomal machinery, as well as through epigenetic modifications. However, to what extent these different mechanisms contribute to the regulation of AS in response to endogenous or environmental stimuli is still unclear. Circadian clocks allow organisms to adjust physiological processes to daily changes in environmental conditions. Here we review recent evidence linking circadian clock and AS, and discuss the role of Protein Arginine Methyltransferase 5 (PRMT5) in these processes. We propose that the interactions between daily oscillations in AS and circadian rhythms in the expression of splicing factors and epigenetic regulators offer a great opportunity to dissect the contribution of these mechanisms to the regulation of AS in a physiologically relevant context. © 2011 Landes Bioscience. Fil:Sanchez, S.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Petrillo, E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Kornblihtt, A.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Yanovsky, M.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2011 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15476286_v8_n6_p_Sanchez http://hdl.handle.net/20.500.12110/paper_15476286_v8_n6_p_Sanchez |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
Alternative splicing Arabidopsis thaliana Circadian clock PRMT5 Transcriptional and post-transcriptional regulation messenger RNA protein arginine methyltransferase protein arginine methyltransferase 5 proteome unclassified drug Arabidopsis protein Dart5 protein, Drosophila Drosophila protein PRMT5 protein, Arabidopsis protein arginine methyltransferase protein methyltransferase alternative RNA splicing circadian rhythm epigenetics genetic variability nonhuman note oscillation regulatory mechanism spliceosome stimulus response animal Arabidopsis biological model circadian rhythm Drosophila melanogaster enzymology genetics metabolism review Arabidopsis thaliana Alternative Splicing Animals Arabidopsis Arabidopsis Proteins Circadian Clocks Drosophila melanogaster Drosophila Proteins Models, Genetic Protein Methyltransferases Protein-Arginine N-Methyltransferases |
spellingShingle |
Alternative splicing Arabidopsis thaliana Circadian clock PRMT5 Transcriptional and post-transcriptional regulation messenger RNA protein arginine methyltransferase protein arginine methyltransferase 5 proteome unclassified drug Arabidopsis protein Dart5 protein, Drosophila Drosophila protein PRMT5 protein, Arabidopsis protein arginine methyltransferase protein methyltransferase alternative RNA splicing circadian rhythm epigenetics genetic variability nonhuman note oscillation regulatory mechanism spliceosome stimulus response animal Arabidopsis biological model circadian rhythm Drosophila melanogaster enzymology genetics metabolism review Arabidopsis thaliana Alternative Splicing Animals Arabidopsis Arabidopsis Proteins Circadian Clocks Drosophila melanogaster Drosophila Proteins Models, Genetic Protein Methyltransferases Protein-Arginine N-Methyltransferases Sanchez, Sabrina Elena Petrillo, Ezequiel Kornblihtt, Alberto Rodolfo Yanovsky, Marcelo Javier Alternative splicing at the right time |
topic_facet |
Alternative splicing Arabidopsis thaliana Circadian clock PRMT5 Transcriptional and post-transcriptional regulation messenger RNA protein arginine methyltransferase protein arginine methyltransferase 5 proteome unclassified drug Arabidopsis protein Dart5 protein, Drosophila Drosophila protein PRMT5 protein, Arabidopsis protein arginine methyltransferase protein methyltransferase alternative RNA splicing circadian rhythm epigenetics genetic variability nonhuman note oscillation regulatory mechanism spliceosome stimulus response animal Arabidopsis biological model circadian rhythm Drosophila melanogaster enzymology genetics metabolism review Arabidopsis thaliana Alternative Splicing Animals Arabidopsis Arabidopsis Proteins Circadian Clocks Drosophila melanogaster Drosophila Proteins Models, Genetic Protein Methyltransferases Protein-Arginine N-Methyltransferases |
description |
Alternative splicing (AS) allows the production of multiple mRNA variants from a single gene, which contributes to increase the complexity of the proteome. There is evidence that AS is regulated not only by auxiliary splicing factors, but also by components of the core spliceosomal machinery, as well as through epigenetic modifications. However, to what extent these different mechanisms contribute to the regulation of AS in response to endogenous or environmental stimuli is still unclear. Circadian clocks allow organisms to adjust physiological processes to daily changes in environmental conditions. Here we review recent evidence linking circadian clock and AS, and discuss the role of Protein Arginine Methyltransferase 5 (PRMT5) in these processes. We propose that the interactions between daily oscillations in AS and circadian rhythms in the expression of splicing factors and epigenetic regulators offer a great opportunity to dissect the contribution of these mechanisms to the regulation of AS in a physiologically relevant context. © 2011 Landes Bioscience. |
author |
Sanchez, Sabrina Elena Petrillo, Ezequiel Kornblihtt, Alberto Rodolfo Yanovsky, Marcelo Javier |
author_facet |
Sanchez, Sabrina Elena Petrillo, Ezequiel Kornblihtt, Alberto Rodolfo Yanovsky, Marcelo Javier |
author_sort |
Sanchez, Sabrina Elena |
title |
Alternative splicing at the right time |
title_short |
Alternative splicing at the right time |
title_full |
Alternative splicing at the right time |
title_fullStr |
Alternative splicing at the right time |
title_full_unstemmed |
Alternative splicing at the right time |
title_sort |
alternative splicing at the right time |
publishDate |
2011 |
url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15476286_v8_n6_p_Sanchez http://hdl.handle.net/20.500.12110/paper_15476286_v8_n6_p_Sanchez |
work_keys_str_mv |
AT sanchezsabrinaelena alternativesplicingattherighttime AT petrilloezequiel alternativesplicingattherighttime AT kornblihttalbertorodolfo alternativesplicingattherighttime AT yanovskymarcelojavier alternativesplicingattherighttime |
_version_ |
1768542613923692544 |