Alternative splicing at the right time

Alternative splicing (AS) allows the production of multiple mRNA variants from a single gene, which contributes to increase the complexity of the proteome. There is evidence that AS is regulated not only by auxiliary splicing factors, but also by components of the core spliceosomal machinery, as wel...

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Autores principales: Sanchez, Sabrina Elena, Petrillo, Ezequiel, Kornblihtt, Alberto Rodolfo, Yanovsky, Marcelo Javier
Publicado: 2011
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Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15476286_v8_n6_p_Sanchez
http://hdl.handle.net/20.500.12110/paper_15476286_v8_n6_p_Sanchez
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spelling paper:paper_15476286_v8_n6_p_Sanchez2023-06-08T16:21:20Z Alternative splicing at the right time Sanchez, Sabrina Elena Petrillo, Ezequiel Kornblihtt, Alberto Rodolfo Yanovsky, Marcelo Javier Alternative splicing Arabidopsis thaliana Circadian clock PRMT5 Transcriptional and post-transcriptional regulation messenger RNA protein arginine methyltransferase protein arginine methyltransferase 5 proteome unclassified drug Arabidopsis protein Dart5 protein, Drosophila Drosophila protein PRMT5 protein, Arabidopsis protein arginine methyltransferase protein methyltransferase alternative RNA splicing circadian rhythm epigenetics genetic variability nonhuman note oscillation regulatory mechanism spliceosome stimulus response animal Arabidopsis biological model circadian rhythm Drosophila melanogaster enzymology genetics metabolism review Arabidopsis thaliana Alternative Splicing Animals Arabidopsis Arabidopsis Proteins Circadian Clocks Drosophila melanogaster Drosophila Proteins Models, Genetic Protein Methyltransferases Protein-Arginine N-Methyltransferases Alternative splicing (AS) allows the production of multiple mRNA variants from a single gene, which contributes to increase the complexity of the proteome. There is evidence that AS is regulated not only by auxiliary splicing factors, but also by components of the core spliceosomal machinery, as well as through epigenetic modifications. However, to what extent these different mechanisms contribute to the regulation of AS in response to endogenous or environmental stimuli is still unclear. Circadian clocks allow organisms to adjust physiological processes to daily changes in environmental conditions. Here we review recent evidence linking circadian clock and AS, and discuss the role of Protein Arginine Methyltransferase 5 (PRMT5) in these processes. We propose that the interactions between daily oscillations in AS and circadian rhythms in the expression of splicing factors and epigenetic regulators offer a great opportunity to dissect the contribution of these mechanisms to the regulation of AS in a physiologically relevant context. © 2011 Landes Bioscience. Fil:Sanchez, S.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Petrillo, E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Kornblihtt, A.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Yanovsky, M.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2011 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15476286_v8_n6_p_Sanchez http://hdl.handle.net/20.500.12110/paper_15476286_v8_n6_p_Sanchez
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Alternative splicing
Arabidopsis thaliana
Circadian clock
PRMT5
Transcriptional and post-transcriptional regulation
messenger RNA
protein arginine methyltransferase
protein arginine methyltransferase 5
proteome
unclassified drug
Arabidopsis protein
Dart5 protein, Drosophila
Drosophila protein
PRMT5 protein, Arabidopsis
protein arginine methyltransferase
protein methyltransferase
alternative RNA splicing
circadian rhythm
epigenetics
genetic variability
nonhuman
note
oscillation
regulatory mechanism
spliceosome
stimulus response
animal
Arabidopsis
biological model
circadian rhythm
Drosophila melanogaster
enzymology
genetics
metabolism
review
Arabidopsis thaliana
Alternative Splicing
Animals
Arabidopsis
Arabidopsis Proteins
Circadian Clocks
Drosophila melanogaster
Drosophila Proteins
Models, Genetic
Protein Methyltransferases
Protein-Arginine N-Methyltransferases
spellingShingle Alternative splicing
Arabidopsis thaliana
Circadian clock
PRMT5
Transcriptional and post-transcriptional regulation
messenger RNA
protein arginine methyltransferase
protein arginine methyltransferase 5
proteome
unclassified drug
Arabidopsis protein
Dart5 protein, Drosophila
Drosophila protein
PRMT5 protein, Arabidopsis
protein arginine methyltransferase
protein methyltransferase
alternative RNA splicing
circadian rhythm
epigenetics
genetic variability
nonhuman
note
oscillation
regulatory mechanism
spliceosome
stimulus response
animal
Arabidopsis
biological model
circadian rhythm
Drosophila melanogaster
enzymology
genetics
metabolism
review
Arabidopsis thaliana
Alternative Splicing
Animals
Arabidopsis
Arabidopsis Proteins
Circadian Clocks
Drosophila melanogaster
Drosophila Proteins
Models, Genetic
Protein Methyltransferases
Protein-Arginine N-Methyltransferases
Sanchez, Sabrina Elena
Petrillo, Ezequiel
Kornblihtt, Alberto Rodolfo
Yanovsky, Marcelo Javier
Alternative splicing at the right time
topic_facet Alternative splicing
Arabidopsis thaliana
Circadian clock
PRMT5
Transcriptional and post-transcriptional regulation
messenger RNA
protein arginine methyltransferase
protein arginine methyltransferase 5
proteome
unclassified drug
Arabidopsis protein
Dart5 protein, Drosophila
Drosophila protein
PRMT5 protein, Arabidopsis
protein arginine methyltransferase
protein methyltransferase
alternative RNA splicing
circadian rhythm
epigenetics
genetic variability
nonhuman
note
oscillation
regulatory mechanism
spliceosome
stimulus response
animal
Arabidopsis
biological model
circadian rhythm
Drosophila melanogaster
enzymology
genetics
metabolism
review
Arabidopsis thaliana
Alternative Splicing
Animals
Arabidopsis
Arabidopsis Proteins
Circadian Clocks
Drosophila melanogaster
Drosophila Proteins
Models, Genetic
Protein Methyltransferases
Protein-Arginine N-Methyltransferases
description Alternative splicing (AS) allows the production of multiple mRNA variants from a single gene, which contributes to increase the complexity of the proteome. There is evidence that AS is regulated not only by auxiliary splicing factors, but also by components of the core spliceosomal machinery, as well as through epigenetic modifications. However, to what extent these different mechanisms contribute to the regulation of AS in response to endogenous or environmental stimuli is still unclear. Circadian clocks allow organisms to adjust physiological processes to daily changes in environmental conditions. Here we review recent evidence linking circadian clock and AS, and discuss the role of Protein Arginine Methyltransferase 5 (PRMT5) in these processes. We propose that the interactions between daily oscillations in AS and circadian rhythms in the expression of splicing factors and epigenetic regulators offer a great opportunity to dissect the contribution of these mechanisms to the regulation of AS in a physiologically relevant context. © 2011 Landes Bioscience.
author Sanchez, Sabrina Elena
Petrillo, Ezequiel
Kornblihtt, Alberto Rodolfo
Yanovsky, Marcelo Javier
author_facet Sanchez, Sabrina Elena
Petrillo, Ezequiel
Kornblihtt, Alberto Rodolfo
Yanovsky, Marcelo Javier
author_sort Sanchez, Sabrina Elena
title Alternative splicing at the right time
title_short Alternative splicing at the right time
title_full Alternative splicing at the right time
title_fullStr Alternative splicing at the right time
title_full_unstemmed Alternative splicing at the right time
title_sort alternative splicing at the right time
publishDate 2011
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15476286_v8_n6_p_Sanchez
http://hdl.handle.net/20.500.12110/paper_15476286_v8_n6_p_Sanchez
work_keys_str_mv AT sanchezsabrinaelena alternativesplicingattherighttime
AT petrilloezequiel alternativesplicingattherighttime
AT kornblihttalbertorodolfo alternativesplicingattherighttime
AT yanovskymarcelojavier alternativesplicingattherighttime
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