Circadian Period Integrates Network Information Through Activation of the BMP Signaling Pathway
Living organisms use biological clocks to maintain their internal temporal order and anticipate daily environmental changes. In Drosophila, circadian regulation of locomotor behavior is controlled by ∼150 neurons; among them, neurons expressing the PIGMENT DISPERSING FACTOR (PDF) set the period of l...
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2013
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15449173_v11_n12_p_Beckwith http://hdl.handle.net/20.500.12110/paper_15449173_v11_n12_p_Beckwith |
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paper:paper_15449173_v11_n12_p_Beckwith |
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paper:paper_15449173_v11_n12_p_Beckwith2023-06-08T16:21:10Z Circadian Period Integrates Network Information Through Activation of the BMP Signaling Pathway bone morphogenetic protein neuropeptide pigment dispersing factor transcription factor CLOCK unclassified drug animal behavior animal cell animal tissue article BMP gene brain cell brain function cellular distribution circadian rhythm controlled study Drosophila gene gene activation gene cluster gene expression regulation gene function gene identification gene interaction gene location genetic conservation genetic screening locomotion molecular clock nerve cell network neurotransmission nonhuman PDF gene protein localization protein protein interaction running signal transduction transcription regulation Animals Bone Morphogenetic Proteins Brain Circadian Rhythm CLOCK Proteins Drosophila melanogaster Drosophila Proteins Motor Activity Neurons Signal Transduction Living organisms use biological clocks to maintain their internal temporal order and anticipate daily environmental changes. In Drosophila, circadian regulation of locomotor behavior is controlled by ∼150 neurons; among them, neurons expressing the PIGMENT DISPERSING FACTOR (PDF) set the period of locomotor behavior under free-running conditions. To date, it remains unclear how individual circadian clusters integrate their activity to assemble a distinctive behavioral output. Here we show that the BONE MORPHOGENETIC PROTEIN (BMP) signaling pathway plays a crucial role in setting the circadian period in PDF neurons in the adult brain. Acute deregulation of BMP signaling causes period lengthening through regulation of dClock transcription, providing evidence for a novel function of this pathway in the adult brain. We propose that coherence in the circadian network arises from integration in PDF neurons of both the pace of the cell-autonomous molecular clock and information derived from circadian-relevant neurons through release of BMP ligands. © 2013 Beckwith et al. 2013 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15449173_v11_n12_p_Beckwith http://hdl.handle.net/20.500.12110/paper_15449173_v11_n12_p_Beckwith |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
bone morphogenetic protein neuropeptide pigment dispersing factor transcription factor CLOCK unclassified drug animal behavior animal cell animal tissue article BMP gene brain cell brain function cellular distribution circadian rhythm controlled study Drosophila gene gene activation gene cluster gene expression regulation gene function gene identification gene interaction gene location genetic conservation genetic screening locomotion molecular clock nerve cell network neurotransmission nonhuman PDF gene protein localization protein protein interaction running signal transduction transcription regulation Animals Bone Morphogenetic Proteins Brain Circadian Rhythm CLOCK Proteins Drosophila melanogaster Drosophila Proteins Motor Activity Neurons Signal Transduction |
| spellingShingle |
bone morphogenetic protein neuropeptide pigment dispersing factor transcription factor CLOCK unclassified drug animal behavior animal cell animal tissue article BMP gene brain cell brain function cellular distribution circadian rhythm controlled study Drosophila gene gene activation gene cluster gene expression regulation gene function gene identification gene interaction gene location genetic conservation genetic screening locomotion molecular clock nerve cell network neurotransmission nonhuman PDF gene protein localization protein protein interaction running signal transduction transcription regulation Animals Bone Morphogenetic Proteins Brain Circadian Rhythm CLOCK Proteins Drosophila melanogaster Drosophila Proteins Motor Activity Neurons Signal Transduction Circadian Period Integrates Network Information Through Activation of the BMP Signaling Pathway |
| topic_facet |
bone morphogenetic protein neuropeptide pigment dispersing factor transcription factor CLOCK unclassified drug animal behavior animal cell animal tissue article BMP gene brain cell brain function cellular distribution circadian rhythm controlled study Drosophila gene gene activation gene cluster gene expression regulation gene function gene identification gene interaction gene location genetic conservation genetic screening locomotion molecular clock nerve cell network neurotransmission nonhuman PDF gene protein localization protein protein interaction running signal transduction transcription regulation Animals Bone Morphogenetic Proteins Brain Circadian Rhythm CLOCK Proteins Drosophila melanogaster Drosophila Proteins Motor Activity Neurons Signal Transduction |
| description |
Living organisms use biological clocks to maintain their internal temporal order and anticipate daily environmental changes. In Drosophila, circadian regulation of locomotor behavior is controlled by ∼150 neurons; among them, neurons expressing the PIGMENT DISPERSING FACTOR (PDF) set the period of locomotor behavior under free-running conditions. To date, it remains unclear how individual circadian clusters integrate their activity to assemble a distinctive behavioral output. Here we show that the BONE MORPHOGENETIC PROTEIN (BMP) signaling pathway plays a crucial role in setting the circadian period in PDF neurons in the adult brain. Acute deregulation of BMP signaling causes period lengthening through regulation of dClock transcription, providing evidence for a novel function of this pathway in the adult brain. We propose that coherence in the circadian network arises from integration in PDF neurons of both the pace of the cell-autonomous molecular clock and information derived from circadian-relevant neurons through release of BMP ligands. © 2013 Beckwith et al. |
| title |
Circadian Period Integrates Network Information Through Activation of the BMP Signaling Pathway |
| title_short |
Circadian Period Integrates Network Information Through Activation of the BMP Signaling Pathway |
| title_full |
Circadian Period Integrates Network Information Through Activation of the BMP Signaling Pathway |
| title_fullStr |
Circadian Period Integrates Network Information Through Activation of the BMP Signaling Pathway |
| title_full_unstemmed |
Circadian Period Integrates Network Information Through Activation of the BMP Signaling Pathway |
| title_sort |
circadian period integrates network information through activation of the bmp signaling pathway |
| publishDate |
2013 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15449173_v11_n12_p_Beckwith http://hdl.handle.net/20.500.12110/paper_15449173_v11_n12_p_Beckwith |
| _version_ |
1768541862010814464 |