Phospholipid alterations elicited by hexachlorobenzene in rat brain are strain-dependent and porphyria-independent
Hexachlorobenzene (HCB) alters phospholipid and heme metabolisms in the liver and Harderian gland. The effects of HCB on phospholipid metabolism, in an organ considered to be non-responsive to its porphyrinogenic effects, remain to be studied. Therefore, as the brain is an organ with this feature, t...
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2001
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paper:paper_15320456_v130_n2_p199_Cochon2023-06-08T16:19:53Z Phospholipid alterations elicited by hexachlorobenzene in rat brain are strain-dependent and porphyria-independent Brain Hexachlorobenzene Phospholipid Porphyria Porphyrin Rat heme hexachlorobenzene phosphatidylcholine phosphatidylethanolamine phosphatidylinositol phosphatidylserine phospholipid porphyrin sphingomyelin animal experiment animal model animal tissue article brain level concentration response controlled study disease severity female hepatic porphyria intoxication lipid composition metabolic disorder nonhuman phospholipid metabolism porphyrin metabolism priority journal rat strain difference time Animals Brain Female Hexachlorobenzene Organ Size Phosphatidylcholines Phosphatidylethanolamines Phosphatidylinositols Phosphatidylserines Phospholipids Porphyrias Porphyrins Rats Rats, Wistar Species Specificity Sphingomyelins Hexachlorobenzene (HCB) alters phospholipid and heme metabolisms in the liver and Harderian gland. The effects of HCB on phospholipid metabolism, in an organ considered to be non-responsive to its porphyrinogenic effects, remain to be studied. Therefore, as the brain is an organ with this feature, this paper analyzes the effects of HCB on brain phospholipid composition in order to investigate if there is any relationship between HCB-induced porphyrin metabolism disruption and phospholipid alterations. For this purpose, a time-course study of HCB effects on brain phospholipids was performed in two strains of rats differing in their susceptibility to acquire hepatic porphyria: Chbb THOM (low); and Wistar (high). This paper shows for the first time that rat brain phospholipids are affected by HCB exposure. Comparative studies show that HCB-induced disturbances in brain phospholipid patterns are time and strain-dependent. Thus, whereas major phospholipids, phosphatidylcholine and phosphatidylethanolamine were more altered in Wistar rats, minor phospholipids, phosphatidylinositol and phosphatidylserine were more affected in Chbb THOM rats. HCB intoxication led to a sphingomyelin/phosphatidylcholine molar ratio lower than the normal, in both strains. As was expected, brain porphyrin content was not altered by HCB intoxication in either strain. It can be concluded that HCB is able to alter brain phospholipid metabolism in a strain-dependent fashion, and in the absence of alterations in brain heme metabolism. In addition, HCB-induced disturbances in brain phospholipids were not related to the degree of hepatic porphyria achieved by the rats. © 2001 Elsevier Science Inc. All rights reserved. 2001 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15320456_v130_n2_p199_Cochon http://hdl.handle.net/20.500.12110/paper_15320456_v130_n2_p199_Cochon |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Brain Hexachlorobenzene Phospholipid Porphyria Porphyrin Rat heme hexachlorobenzene phosphatidylcholine phosphatidylethanolamine phosphatidylinositol phosphatidylserine phospholipid porphyrin sphingomyelin animal experiment animal model animal tissue article brain level concentration response controlled study disease severity female hepatic porphyria intoxication lipid composition metabolic disorder nonhuman phospholipid metabolism porphyrin metabolism priority journal rat strain difference time Animals Brain Female Hexachlorobenzene Organ Size Phosphatidylcholines Phosphatidylethanolamines Phosphatidylinositols Phosphatidylserines Phospholipids Porphyrias Porphyrins Rats Rats, Wistar Species Specificity Sphingomyelins |
| spellingShingle |
Brain Hexachlorobenzene Phospholipid Porphyria Porphyrin Rat heme hexachlorobenzene phosphatidylcholine phosphatidylethanolamine phosphatidylinositol phosphatidylserine phospholipid porphyrin sphingomyelin animal experiment animal model animal tissue article brain level concentration response controlled study disease severity female hepatic porphyria intoxication lipid composition metabolic disorder nonhuman phospholipid metabolism porphyrin metabolism priority journal rat strain difference time Animals Brain Female Hexachlorobenzene Organ Size Phosphatidylcholines Phosphatidylethanolamines Phosphatidylinositols Phosphatidylserines Phospholipids Porphyrias Porphyrins Rats Rats, Wistar Species Specificity Sphingomyelins Phospholipid alterations elicited by hexachlorobenzene in rat brain are strain-dependent and porphyria-independent |
| topic_facet |
Brain Hexachlorobenzene Phospholipid Porphyria Porphyrin Rat heme hexachlorobenzene phosphatidylcholine phosphatidylethanolamine phosphatidylinositol phosphatidylserine phospholipid porphyrin sphingomyelin animal experiment animal model animal tissue article brain level concentration response controlled study disease severity female hepatic porphyria intoxication lipid composition metabolic disorder nonhuman phospholipid metabolism porphyrin metabolism priority journal rat strain difference time Animals Brain Female Hexachlorobenzene Organ Size Phosphatidylcholines Phosphatidylethanolamines Phosphatidylinositols Phosphatidylserines Phospholipids Porphyrias Porphyrins Rats Rats, Wistar Species Specificity Sphingomyelins |
| description |
Hexachlorobenzene (HCB) alters phospholipid and heme metabolisms in the liver and Harderian gland. The effects of HCB on phospholipid metabolism, in an organ considered to be non-responsive to its porphyrinogenic effects, remain to be studied. Therefore, as the brain is an organ with this feature, this paper analyzes the effects of HCB on brain phospholipid composition in order to investigate if there is any relationship between HCB-induced porphyrin metabolism disruption and phospholipid alterations. For this purpose, a time-course study of HCB effects on brain phospholipids was performed in two strains of rats differing in their susceptibility to acquire hepatic porphyria: Chbb THOM (low); and Wistar (high). This paper shows for the first time that rat brain phospholipids are affected by HCB exposure. Comparative studies show that HCB-induced disturbances in brain phospholipid patterns are time and strain-dependent. Thus, whereas major phospholipids, phosphatidylcholine and phosphatidylethanolamine were more altered in Wistar rats, minor phospholipids, phosphatidylinositol and phosphatidylserine were more affected in Chbb THOM rats. HCB intoxication led to a sphingomyelin/phosphatidylcholine molar ratio lower than the normal, in both strains. As was expected, brain porphyrin content was not altered by HCB intoxication in either strain. It can be concluded that HCB is able to alter brain phospholipid metabolism in a strain-dependent fashion, and in the absence of alterations in brain heme metabolism. In addition, HCB-induced disturbances in brain phospholipids were not related to the degree of hepatic porphyria achieved by the rats. © 2001 Elsevier Science Inc. All rights reserved. |
| title |
Phospholipid alterations elicited by hexachlorobenzene in rat brain are strain-dependent and porphyria-independent |
| title_short |
Phospholipid alterations elicited by hexachlorobenzene in rat brain are strain-dependent and porphyria-independent |
| title_full |
Phospholipid alterations elicited by hexachlorobenzene in rat brain are strain-dependent and porphyria-independent |
| title_fullStr |
Phospholipid alterations elicited by hexachlorobenzene in rat brain are strain-dependent and porphyria-independent |
| title_full_unstemmed |
Phospholipid alterations elicited by hexachlorobenzene in rat brain are strain-dependent and porphyria-independent |
| title_sort |
phospholipid alterations elicited by hexachlorobenzene in rat brain are strain-dependent and porphyria-independent |
| publishDate |
2001 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15320456_v130_n2_p199_Cochon http://hdl.handle.net/20.500.12110/paper_15320456_v130_n2_p199_Cochon |
| _version_ |
1768542051754835968 |