Dissecting the signal transduction pathways triggered by galectin-glycan interactions in physiological and pathological settings
Galectins are a family of evolutionarily conserved animal lectins with pleiotropic functions and widespread distribution. Fifteen members have been identified in a wide variety of cells and tissues. Through recognition of cell surface glycoproteins and glycolipids, these endogenous lectins can trigg...
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2010
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15216543_v62_n1_p1_Laderach http://hdl.handle.net/20.500.12110/paper_15216543_v62_n1_p1_Laderach |
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paper:paper_15216543_v62_n1_p1_Laderach2023-06-08T16:19:16Z Dissecting the signal transduction pathways triggered by galectin-glycan interactions in physiological and pathological settings Toscano, Marta Alicia Croci Russo, Diego Omar Salatino, Mariana Apoptosis Differentiation Galectins Immune regulation Oncogenesis Signaling pathways galaptin galectin glycan galectin polysaccharide cell adhesion cell differentiation cell proliferation cell transformation connective tissue embryo development hematopoietic system nervous tissue protein expression protein function protein interaction review signal transduction tumor cell animal hematopoiesis human metabolism neoplasm pathophysiology physiology signal transduction Animalia Animals Galectins Hematopoiesis Humans Neoplasms Polysaccharides Signal Transduction Galectins are a family of evolutionarily conserved animal lectins with pleiotropic functions and widespread distribution. Fifteen members have been identified in a wide variety of cells and tissues. Through recognition of cell surface glycoproteins and glycolipids, these endogenous lectins can trigger a cascade of intracellular signaling pathways capable of modulating cell differentiation, proliferation, survival, and migration. These cellular events are critical in a variety of biological processes including embryogenesis, angiogenesis, neurogenesis, and immunity and are substantially altered during tumorigenesis, neurodegeneration, and inflammation. In addition, galectins can modulate intracellular functions and this effect involves direct interactions with distinct signaling pathways. In this review, we discuss current knowledge on the intracellular signaling pathways triggered by this multifunctional family of β-galactoside-binding proteins in selected physiological and pathological settings. Understanding the "galectin signalosome" will be essential to delineate rational therapeutic strategies based on the specific control of galectin expression and function. © 2009 IUBMB. Fil:Toscano, M.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Croci, D.O. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Salatino, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2010 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15216543_v62_n1_p1_Laderach http://hdl.handle.net/20.500.12110/paper_15216543_v62_n1_p1_Laderach |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Apoptosis Differentiation Galectins Immune regulation Oncogenesis Signaling pathways galaptin galectin glycan galectin polysaccharide cell adhesion cell differentiation cell proliferation cell transformation connective tissue embryo development hematopoietic system nervous tissue protein expression protein function protein interaction review signal transduction tumor cell animal hematopoiesis human metabolism neoplasm pathophysiology physiology signal transduction Animalia Animals Galectins Hematopoiesis Humans Neoplasms Polysaccharides Signal Transduction |
| spellingShingle |
Apoptosis Differentiation Galectins Immune regulation Oncogenesis Signaling pathways galaptin galectin glycan galectin polysaccharide cell adhesion cell differentiation cell proliferation cell transformation connective tissue embryo development hematopoietic system nervous tissue protein expression protein function protein interaction review signal transduction tumor cell animal hematopoiesis human metabolism neoplasm pathophysiology physiology signal transduction Animalia Animals Galectins Hematopoiesis Humans Neoplasms Polysaccharides Signal Transduction Toscano, Marta Alicia Croci Russo, Diego Omar Salatino, Mariana Dissecting the signal transduction pathways triggered by galectin-glycan interactions in physiological and pathological settings |
| topic_facet |
Apoptosis Differentiation Galectins Immune regulation Oncogenesis Signaling pathways galaptin galectin glycan galectin polysaccharide cell adhesion cell differentiation cell proliferation cell transformation connective tissue embryo development hematopoietic system nervous tissue protein expression protein function protein interaction review signal transduction tumor cell animal hematopoiesis human metabolism neoplasm pathophysiology physiology signal transduction Animalia Animals Galectins Hematopoiesis Humans Neoplasms Polysaccharides Signal Transduction |
| description |
Galectins are a family of evolutionarily conserved animal lectins with pleiotropic functions and widespread distribution. Fifteen members have been identified in a wide variety of cells and tissues. Through recognition of cell surface glycoproteins and glycolipids, these endogenous lectins can trigger a cascade of intracellular signaling pathways capable of modulating cell differentiation, proliferation, survival, and migration. These cellular events are critical in a variety of biological processes including embryogenesis, angiogenesis, neurogenesis, and immunity and are substantially altered during tumorigenesis, neurodegeneration, and inflammation. In addition, galectins can modulate intracellular functions and this effect involves direct interactions with distinct signaling pathways. In this review, we discuss current knowledge on the intracellular signaling pathways triggered by this multifunctional family of β-galactoside-binding proteins in selected physiological and pathological settings. Understanding the "galectin signalosome" will be essential to delineate rational therapeutic strategies based on the specific control of galectin expression and function. © 2009 IUBMB. |
| author |
Toscano, Marta Alicia Croci Russo, Diego Omar Salatino, Mariana |
| author_facet |
Toscano, Marta Alicia Croci Russo, Diego Omar Salatino, Mariana |
| author_sort |
Toscano, Marta Alicia |
| title |
Dissecting the signal transduction pathways triggered by galectin-glycan interactions in physiological and pathological settings |
| title_short |
Dissecting the signal transduction pathways triggered by galectin-glycan interactions in physiological and pathological settings |
| title_full |
Dissecting the signal transduction pathways triggered by galectin-glycan interactions in physiological and pathological settings |
| title_fullStr |
Dissecting the signal transduction pathways triggered by galectin-glycan interactions in physiological and pathological settings |
| title_full_unstemmed |
Dissecting the signal transduction pathways triggered by galectin-glycan interactions in physiological and pathological settings |
| title_sort |
dissecting the signal transduction pathways triggered by galectin-glycan interactions in physiological and pathological settings |
| publishDate |
2010 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15216543_v62_n1_p1_Laderach http://hdl.handle.net/20.500.12110/paper_15216543_v62_n1_p1_Laderach |
| work_keys_str_mv |
AT toscanomartaalicia dissectingthesignaltransductionpathwaystriggeredbygalectinglycaninteractionsinphysiologicalandpathologicalsettings AT crocirussodiegoomar dissectingthesignaltransductionpathwaystriggeredbygalectinglycaninteractionsinphysiologicalandpathologicalsettings AT salatinomariana dissectingthesignaltransductionpathwaystriggeredbygalectinglycaninteractionsinphysiologicalandpathologicalsettings |
| _version_ |
1768544701153017856 |