Effects of dimethyl sulfoxide on lipid membrane electroporation

Pores can be generated in lipid membranes by the application of an external electric field or by the addition of particular chemicals such as dimethyl sulfoxide (DMSO). Molecular dynamics (MD) has been shown to be a useful tool for unveiling many aspects of pore formation in lipid membranes in both...

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Autor principal:	Fernández, María Laura
Publicado:	2014
Materias:	Dimethyl sulfoxide Electric fields Lipid bilayers Lipids Molecular dynamics Chemical mechanism Dimethyl sulfoxide (DMSO) External electric field Favorable conditions Hydrophobic pore Lipid membranes Membrane pores Physico-chemical mechanisms Organic solvents 1,2-oleoylphosphatidylcholine cholesterol dimethyl sulfoxide lipid bilayer phosphatidylcholine chemical phenomena chemistry electroporation molecular dynamics porosity pressure procedures Cholesterol Dimethyl Sulfoxide Electroporation Hydrophobic and Hydrophilic Interactions Lipid Bilayers Molecular Dynamics Simulation Phosphatidylcholines Porosity Pressure
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15206106_v118_n31_p9306_Fernandez http://hdl.handle.net/20.500.12110/paper_15206106_v118_n31_p9306_Fernandez
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_15206106_v118_n31_p9306_Fernandez
record_format	dspace
spelling	paper:paper_15206106_v118_n31_p9306_Fernandez2023-06-08T16:19:08Z Effects of dimethyl sulfoxide on lipid membrane electroporation Fernández, María Laura Dimethyl sulfoxide Electric fields Lipid bilayers Lipids Molecular dynamics Chemical mechanism Dimethyl sulfoxide (DMSO) External electric field Favorable conditions Hydrophobic pore Lipid membranes Membrane pores Physico-chemical mechanisms Organic solvents 1,2-oleoylphosphatidylcholine cholesterol dimethyl sulfoxide lipid bilayer phosphatidylcholine chemical phenomena chemistry electroporation lipid bilayer molecular dynamics porosity pressure procedures Cholesterol Dimethyl Sulfoxide Electroporation Hydrophobic and Hydrophilic Interactions Lipid Bilayers Molecular Dynamics Simulation Phosphatidylcholines Porosity Pressure Pores can be generated in lipid membranes by the application of an external electric field or by the addition of particular chemicals such as dimethyl sulfoxide (DMSO). Molecular dynamics (MD) has been shown to be a useful tool for unveiling many aspects of pore formation in lipid membranes in both situations. By means of MD simulations, we address the formation of electropores in cholesterol-containing lipid bilayers under the influence of DMSO. We show how a combination of physical and chemical mechanisms leads to more favorable conditions for generating membrane pores and, in particular, how the addition of DMSO to the medium significantly reduces the minimum electric field required to electroporate a lipid membrane. The strong alteration of membrane transversal properties and the energetic stabilization of the hydrophobic pore stage by DMSO provide the physicochemical mechanisms that explain this effect. © 2014 American Chemical Society. Fil:Fernández, M.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2014 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15206106_v118_n31_p9306_Fernandez http://hdl.handle.net/20.500.12110/paper_15206106_v118_n31_p9306_Fernandez
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Dimethyl sulfoxide Electric fields Lipid bilayers Lipids Molecular dynamics Chemical mechanism Dimethyl sulfoxide (DMSO) External electric field Favorable conditions Hydrophobic pore Lipid membranes Membrane pores Physico-chemical mechanisms Organic solvents 1,2-oleoylphosphatidylcholine cholesterol dimethyl sulfoxide lipid bilayer phosphatidylcholine chemical phenomena chemistry electroporation lipid bilayer molecular dynamics porosity pressure procedures Cholesterol Dimethyl Sulfoxide Electroporation Hydrophobic and Hydrophilic Interactions Lipid Bilayers Molecular Dynamics Simulation Phosphatidylcholines Porosity Pressure
spellingShingle	Dimethyl sulfoxide Electric fields Lipid bilayers Lipids Molecular dynamics Chemical mechanism Dimethyl sulfoxide (DMSO) External electric field Favorable conditions Hydrophobic pore Lipid membranes Membrane pores Physico-chemical mechanisms Organic solvents 1,2-oleoylphosphatidylcholine cholesterol dimethyl sulfoxide lipid bilayer phosphatidylcholine chemical phenomena chemistry electroporation lipid bilayer molecular dynamics porosity pressure procedures Cholesterol Dimethyl Sulfoxide Electroporation Hydrophobic and Hydrophilic Interactions Lipid Bilayers Molecular Dynamics Simulation Phosphatidylcholines Porosity Pressure Fernández, María Laura Effects of dimethyl sulfoxide on lipid membrane electroporation
topic_facet	Dimethyl sulfoxide Electric fields Lipid bilayers Lipids Molecular dynamics Chemical mechanism Dimethyl sulfoxide (DMSO) External electric field Favorable conditions Hydrophobic pore Lipid membranes Membrane pores Physico-chemical mechanisms Organic solvents 1,2-oleoylphosphatidylcholine cholesterol dimethyl sulfoxide lipid bilayer phosphatidylcholine chemical phenomena chemistry electroporation lipid bilayer molecular dynamics porosity pressure procedures Cholesterol Dimethyl Sulfoxide Electroporation Hydrophobic and Hydrophilic Interactions Lipid Bilayers Molecular Dynamics Simulation Phosphatidylcholines Porosity Pressure
description	Pores can be generated in lipid membranes by the application of an external electric field or by the addition of particular chemicals such as dimethyl sulfoxide (DMSO). Molecular dynamics (MD) has been shown to be a useful tool for unveiling many aspects of pore formation in lipid membranes in both situations. By means of MD simulations, we address the formation of electropores in cholesterol-containing lipid bilayers under the influence of DMSO. We show how a combination of physical and chemical mechanisms leads to more favorable conditions for generating membrane pores and, in particular, how the addition of DMSO to the medium significantly reduces the minimum electric field required to electroporate a lipid membrane. The strong alteration of membrane transversal properties and the energetic stabilization of the hydrophobic pore stage by DMSO provide the physicochemical mechanisms that explain this effect. © 2014 American Chemical Society.
author	Fernández, María Laura
author_facet	Fernández, María Laura
author_sort	Fernández, María Laura
title	Effects of dimethyl sulfoxide on lipid membrane electroporation
title_short	Effects of dimethyl sulfoxide on lipid membrane electroporation
title_full	Effects of dimethyl sulfoxide on lipid membrane electroporation
title_fullStr	Effects of dimethyl sulfoxide on lipid membrane electroporation
title_full_unstemmed	Effects of dimethyl sulfoxide on lipid membrane electroporation
title_sort	effects of dimethyl sulfoxide on lipid membrane electroporation
publishDate	2014
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15206106_v118_n31_p9306_Fernandez http://hdl.handle.net/20.500.12110/paper_15206106_v118_n31_p9306_Fernandez
work_keys_str_mv	AT fernandezmarialaura effectsofdimethylsulfoxideonlipidmembraneelectroporation
_version_	1768545161105637376

Effects of dimethyl sulfoxide on lipid membrane electroporation

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