One-step synthesis of N, N′-substituted 4-imidazolidinones by an isocyanide-based pseudo-five-multicomponent reaction

A pseudo-five-multicomponent reaction involving an isocyanide, a primary amine, two molecules of formaldehyde and water is reported, which gives N,N′-substituted 4-imidazolidinones when trifluoroethanol is used as the solvent. The reaction proceeds with good yields and with a wide variety of amines...

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Detalles Bibliográficos
Publicado:	2018
Materias:	Amines Cyanides Ethanol Polyols Heterocycles Isocyanides Multi-component reactions One step synthesis Primary amines Reaction mechanism Reaction pathways Trifluoroethanol Chemical reactions
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14770520_v16_n46_p8944_Attorresi http://hdl.handle.net/20.500.12110/paper_14770520_v16_n46_p8944_Attorresi
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_14770520_v16_n46_p8944_Attorresi
record_format	dspace
spelling	paper:paper_14770520_v16_n46_p8944_Attorresi2023-06-08T16:18:05Z One-step synthesis of N, N′-substituted 4-imidazolidinones by an isocyanide-based pseudo-five-multicomponent reaction Amines Cyanides Ethanol Polyols Heterocycles Isocyanides Multi-component reactions One step synthesis Primary amines Reaction mechanism Reaction pathways Trifluoroethanol Chemical reactions A pseudo-five-multicomponent reaction involving an isocyanide, a primary amine, two molecules of formaldehyde and water is reported, which gives N,N′-substituted 4-imidazolidinones when trifluoroethanol is used as the solvent. The reaction proceeds with good yields and with a wide variety of amines and isocyanides, providing an efficient new entry to these heterocycles. A preliminary study of the reaction mechanism suggests that trifluoroethanol, although acting as the solvent, is directly involved as a reagent in the reaction pathway. © 2018 The Royal Society of Chemistry. 2018 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14770520_v16_n46_p8944_Attorresi http://hdl.handle.net/20.500.12110/paper_14770520_v16_n46_p8944_Attorresi
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Amines Cyanides Ethanol Polyols Heterocycles Isocyanides Multi-component reactions One step synthesis Primary amines Reaction mechanism Reaction pathways Trifluoroethanol Chemical reactions
spellingShingle	Amines Cyanides Ethanol Polyols Heterocycles Isocyanides Multi-component reactions One step synthesis Primary amines Reaction mechanism Reaction pathways Trifluoroethanol Chemical reactions One-step synthesis of N, N′-substituted 4-imidazolidinones by an isocyanide-based pseudo-five-multicomponent reaction
topic_facet	Amines Cyanides Ethanol Polyols Heterocycles Isocyanides Multi-component reactions One step synthesis Primary amines Reaction mechanism Reaction pathways Trifluoroethanol Chemical reactions
description	A pseudo-five-multicomponent reaction involving an isocyanide, a primary amine, two molecules of formaldehyde and water is reported, which gives N,N′-substituted 4-imidazolidinones when trifluoroethanol is used as the solvent. The reaction proceeds with good yields and with a wide variety of amines and isocyanides, providing an efficient new entry to these heterocycles. A preliminary study of the reaction mechanism suggests that trifluoroethanol, although acting as the solvent, is directly involved as a reagent in the reaction pathway. © 2018 The Royal Society of Chemistry.
title	One-step synthesis of N, N′-substituted 4-imidazolidinones by an isocyanide-based pseudo-five-multicomponent reaction
title_short	One-step synthesis of N, N′-substituted 4-imidazolidinones by an isocyanide-based pseudo-five-multicomponent reaction
title_full	One-step synthesis of N, N′-substituted 4-imidazolidinones by an isocyanide-based pseudo-five-multicomponent reaction
title_fullStr	One-step synthesis of N, N′-substituted 4-imidazolidinones by an isocyanide-based pseudo-five-multicomponent reaction
title_full_unstemmed	One-step synthesis of N, N′-substituted 4-imidazolidinones by an isocyanide-based pseudo-five-multicomponent reaction
title_sort	one-step synthesis of n, n′-substituted 4-imidazolidinones by an isocyanide-based pseudo-five-multicomponent reaction
publishDate	2018
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14770520_v16_n46_p8944_Attorresi http://hdl.handle.net/20.500.12110/paper_14770520_v16_n46_p8944_Attorresi
_version_	1768543388247785472

One-step synthesis of N, N′-substituted 4-imidazolidinones by an isocyanide-based pseudo-five-multicomponent reaction

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