Galectin-1 as a potential therapeutic target in autoimmune disorders and cancer
Galectin-1, a member of a family of highly conserved glycan-binding proteins, has emerged as a regulator of immune cell tolerance and homeostasis. This endogenous lectin widely expressed at sites of inflammation and tumour growth, has been postulated as an attractive immunosuppressive agent to resto...
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2008
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14712598_v8_n1_p45_Salatino http://hdl.handle.net/20.500.12110/paper_14712598_v8_n1_p45_Salatino |
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paper:paper_14712598_v8_n1_p45_Salatino2023-06-08T16:17:20Z Galectin-1 as a potential therapeutic target in autoimmune disorders and cancer Autoimmunity Cancer Glycoimmunology Immunomodularion Tumour-immune escape binding protein cyclophosphamide galectin galectin 1 glycan glycoprotein immunosuppressive agent lectin recombinant galectin 1 recombinant protein retinoic acid unclassified drug galectin 1 immunosuppressive agent autoimmune disease cell adhesion cell migration drug targeting homeostasis human immunocompetent cell immunological tolerance immunoregulation inflammation inflammatory disease metastasis neoplasm nonhuman protein expression review Th1 cell tumor escape tumor growth autoimmune disease helper cell immunology neoplasm physiology Autoimmune Diseases Galectin 1 Humans Immunosuppressive Agents Neoplasms T-Lymphocytes, Helper-Inducer Galectin-1, a member of a family of highly conserved glycan-binding proteins, has emerged as a regulator of immune cell tolerance and homeostasis. This endogenous lectin widely expressed at sites of inflammation and tumour growth, has been postulated as an attractive immunosuppressive agent to restore immune cell tolerance and homeostasis in autoimmune and inflammatory settings. On the other hand, galectin-1 contributes to different steps of tumour progression including cell adhesion, migration and tumour-immune escape, suggesting that blockade of galectin-1 might result in therapeutic benefits in cancer. Recent findings implicating galectin-glycoprotein lattices as selective regulators of inflammatory responses have provided new insights into the understanding of the molecular bases of galectin-1-induced immunoregulation. Here the authors review the dual role of galectin-1 as a selective immunosuppressive agent in T helper (TH)1 and TH17-mediated inflammatory/autoimmune disorders and a potential therapeutic target in cancer and metastasis. © 2008 Informa UK Ltd. 2008 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14712598_v8_n1_p45_Salatino http://hdl.handle.net/20.500.12110/paper_14712598_v8_n1_p45_Salatino |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Autoimmunity Cancer Glycoimmunology Immunomodularion Tumour-immune escape binding protein cyclophosphamide galectin galectin 1 glycan glycoprotein immunosuppressive agent lectin recombinant galectin 1 recombinant protein retinoic acid unclassified drug galectin 1 immunosuppressive agent autoimmune disease cell adhesion cell migration drug targeting homeostasis human immunocompetent cell immunological tolerance immunoregulation inflammation inflammatory disease metastasis neoplasm nonhuman protein expression review Th1 cell tumor escape tumor growth autoimmune disease helper cell immunology neoplasm physiology Autoimmune Diseases Galectin 1 Humans Immunosuppressive Agents Neoplasms T-Lymphocytes, Helper-Inducer |
| spellingShingle |
Autoimmunity Cancer Glycoimmunology Immunomodularion Tumour-immune escape binding protein cyclophosphamide galectin galectin 1 glycan glycoprotein immunosuppressive agent lectin recombinant galectin 1 recombinant protein retinoic acid unclassified drug galectin 1 immunosuppressive agent autoimmune disease cell adhesion cell migration drug targeting homeostasis human immunocompetent cell immunological tolerance immunoregulation inflammation inflammatory disease metastasis neoplasm nonhuman protein expression review Th1 cell tumor escape tumor growth autoimmune disease helper cell immunology neoplasm physiology Autoimmune Diseases Galectin 1 Humans Immunosuppressive Agents Neoplasms T-Lymphocytes, Helper-Inducer Galectin-1 as a potential therapeutic target in autoimmune disorders and cancer |
| topic_facet |
Autoimmunity Cancer Glycoimmunology Immunomodularion Tumour-immune escape binding protein cyclophosphamide galectin galectin 1 glycan glycoprotein immunosuppressive agent lectin recombinant galectin 1 recombinant protein retinoic acid unclassified drug galectin 1 immunosuppressive agent autoimmune disease cell adhesion cell migration drug targeting homeostasis human immunocompetent cell immunological tolerance immunoregulation inflammation inflammatory disease metastasis neoplasm nonhuman protein expression review Th1 cell tumor escape tumor growth autoimmune disease helper cell immunology neoplasm physiology Autoimmune Diseases Galectin 1 Humans Immunosuppressive Agents Neoplasms T-Lymphocytes, Helper-Inducer |
| description |
Galectin-1, a member of a family of highly conserved glycan-binding proteins, has emerged as a regulator of immune cell tolerance and homeostasis. This endogenous lectin widely expressed at sites of inflammation and tumour growth, has been postulated as an attractive immunosuppressive agent to restore immune cell tolerance and homeostasis in autoimmune and inflammatory settings. On the other hand, galectin-1 contributes to different steps of tumour progression including cell adhesion, migration and tumour-immune escape, suggesting that blockade of galectin-1 might result in therapeutic benefits in cancer. Recent findings implicating galectin-glycoprotein lattices as selective regulators of inflammatory responses have provided new insights into the understanding of the molecular bases of galectin-1-induced immunoregulation. Here the authors review the dual role of galectin-1 as a selective immunosuppressive agent in T helper (TH)1 and TH17-mediated inflammatory/autoimmune disorders and a potential therapeutic target in cancer and metastasis. © 2008 Informa UK Ltd. |
| title |
Galectin-1 as a potential therapeutic target in autoimmune disorders and cancer |
| title_short |
Galectin-1 as a potential therapeutic target in autoimmune disorders and cancer |
| title_full |
Galectin-1 as a potential therapeutic target in autoimmune disorders and cancer |
| title_fullStr |
Galectin-1 as a potential therapeutic target in autoimmune disorders and cancer |
| title_full_unstemmed |
Galectin-1 as a potential therapeutic target in autoimmune disorders and cancer |
| title_sort |
galectin-1 as a potential therapeutic target in autoimmune disorders and cancer |
| publishDate |
2008 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14712598_v8_n1_p45_Salatino http://hdl.handle.net/20.500.12110/paper_14712598_v8_n1_p45_Salatino |
| _version_ |
1768542236884074496 |