Enhanced Antitumor Activity against Melanoma Cancer Cells by Nitric Oxide Release and Photosensitized Generation of Singlet Oxygen from Ruthenium Complexes

We have investigated the synergistic effect of nitric oxide and singlet oxygen originating from stimulated ruthenium complexes and their photodynamic action against a melanoma cancer cell line. In aqueous solution, the photosensitizer [Ru(NH3)5pz]2+(I; pz = pyrazine) and the nitrosylruthenium comple...

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Detalles Bibliográficos
Autor principal: Slep, Leonardo Daniel
Publicado: 2016
Materias:
Antitumor agents
Nitrogen oxides
Ruthenium
Singlet oxygen
Toxicity
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14341948_v2016_n22_p3592_Ramos
http://hdl.handle.net/20.500.12110/paper_14341948_v2016_n22_p3592_Ramos
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_14341948_v2016_n22_p3592_Ramos
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spelling paper:paper_14341948_v2016_n22_p3592_Ramos2023-06-08T16:14:27Z Enhanced Antitumor Activity against Melanoma Cancer Cells by Nitric Oxide Release and Photosensitized Generation of Singlet Oxygen from Ruthenium Complexes Slep, Leonardo Daniel Antitumor agents Nitrogen oxides Ruthenium Singlet oxygen Toxicity We have investigated the synergistic effect of nitric oxide and singlet oxygen originating from stimulated ruthenium complexes and their photodynamic action against a melanoma cancer cell line. In aqueous solution, the photosensitizer [Ru(NH3)5pz]2+(I; pz = pyrazine) and the nitrosylruthenium complex trans-[RuCl([15]aneN4)NO]2+(II; [15]aneN4= 1,4,8,12-tetrazacyclopentadecane) can produce singlet oxygen and nitric oxide, respectively. The phototoxicity of complex I does not correlate with the singlet oxygen quantum yields unless it is mediated by nitric oxide release from complex II. This effect is around 70 and 50 % higher than the effect prompted by compounds I and II, respectively, in isolation in the presence of light. It was found that the number of hypodiploid cells in the melanoma cancer cells increased, which indicates that a mixture of compounds I and II induces apoptosis of tumorigenic cell lines. Both singlet oxygen and nitric oxide produced by the ruthenium complexes enhance the photodynamic efficacy in melanoma cancer cells. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Fil:Slep, L.D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2016 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14341948_v2016_n22_p3592_Ramos http://hdl.handle.net/20.500.12110/paper_14341948_v2016_n22_p3592_Ramos
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Antitumor agents
Nitrogen oxides
Ruthenium
Singlet oxygen
Toxicity
spellingShingle Antitumor agents
Nitrogen oxides
Ruthenium
Singlet oxygen
Toxicity
Slep, Leonardo Daniel
Enhanced Antitumor Activity against Melanoma Cancer Cells by Nitric Oxide Release and Photosensitized Generation of Singlet Oxygen from Ruthenium Complexes
topic_facet Antitumor agents
Nitrogen oxides
Ruthenium
Singlet oxygen
Toxicity
description We have investigated the synergistic effect of nitric oxide and singlet oxygen originating from stimulated ruthenium complexes and their photodynamic action against a melanoma cancer cell line. In aqueous solution, the photosensitizer [Ru(NH3)5pz]2+(I; pz = pyrazine) and the nitrosylruthenium complex trans-[RuCl([15]aneN4)NO]2+(II; [15]aneN4= 1,4,8,12-tetrazacyclopentadecane) can produce singlet oxygen and nitric oxide, respectively. The phototoxicity of complex I does not correlate with the singlet oxygen quantum yields unless it is mediated by nitric oxide release from complex II. This effect is around 70 and 50 % higher than the effect prompted by compounds I and II, respectively, in isolation in the presence of light. It was found that the number of hypodiploid cells in the melanoma cancer cells increased, which indicates that a mixture of compounds I and II induces apoptosis of tumorigenic cell lines. Both singlet oxygen and nitric oxide produced by the ruthenium complexes enhance the photodynamic efficacy in melanoma cancer cells. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
author Slep, Leonardo Daniel
author_facet Slep, Leonardo Daniel
author_sort Slep, Leonardo Daniel
title Enhanced Antitumor Activity against Melanoma Cancer Cells by Nitric Oxide Release and Photosensitized Generation of Singlet Oxygen from Ruthenium Complexes
title_short Enhanced Antitumor Activity against Melanoma Cancer Cells by Nitric Oxide Release and Photosensitized Generation of Singlet Oxygen from Ruthenium Complexes
title_full Enhanced Antitumor Activity against Melanoma Cancer Cells by Nitric Oxide Release and Photosensitized Generation of Singlet Oxygen from Ruthenium Complexes
title_fullStr Enhanced Antitumor Activity against Melanoma Cancer Cells by Nitric Oxide Release and Photosensitized Generation of Singlet Oxygen from Ruthenium Complexes
title_full_unstemmed Enhanced Antitumor Activity against Melanoma Cancer Cells by Nitric Oxide Release and Photosensitized Generation of Singlet Oxygen from Ruthenium Complexes
title_sort enhanced antitumor activity against melanoma cancer cells by nitric oxide release and photosensitized generation of singlet oxygen from ruthenium complexes
publishDate 2016
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14341948_v2016_n22_p3592_Ramos
http://hdl.handle.net/20.500.12110/paper_14341948_v2016_n22_p3592_Ramos
work_keys_str_mv AT slepleonardodaniel enhancedantitumoractivityagainstmelanomacancercellsbynitricoxidereleaseandphotosensitizedgenerationofsingletoxygenfromrutheniumcomplexes
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