New progresses in the enantioselective synthesis and biological properties of carbocyclic nucleosides.

The recent advances in the chemistry of carbocyclic nucleosides focused on different synthetic approaches that lead to optically pure products as well as a comprehensive overview of their biological properties are discussed. In the latter aspect, molecular recognition of enzymes of pharmacological i...

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Autores principales:	Rodríguez, Juan Bautista, Comin, María Julieta
Publicado:	2003
Materias:	2',3' dideoxynucleoside derivative alkanone anti human immunodeficiency virus agent antineoplastic agent carbovir cyclohexane derivative cyclopentane derivative cyclopropane derivative glyceraldehyde glycoside nucleoside chemistry conformation cyclization human review stereoisomerism synthesis Anti-HIV Agents Antineoplastic Agents Butanones Cyclization Cyclohexanes Cyclopentanes Cyclopropanes Dideoxynucleosides Glyceraldehyde Glycosides Humans Molecular Conformation Nucleosides Stereoisomerism
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13895575_v3_n2_p95_Rodriguez http://hdl.handle.net/20.500.12110/paper_13895575_v3_n2_p95_Rodriguez
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_13895575_v3_n2_p95_Rodriguez
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spelling	paper:paper_13895575_v3_n2_p95_Rodriguez2023-06-08T16:13:10Z New progresses in the enantioselective synthesis and biological properties of carbocyclic nucleosides. Rodríguez, Juan Bautista Comin, María Julieta 2',3' dideoxynucleoside derivative alkanone anti human immunodeficiency virus agent antineoplastic agent carbovir cyclohexane derivative cyclopentane derivative cyclopropane derivative glyceraldehyde glycoside nucleoside chemistry conformation cyclization human review stereoisomerism synthesis Anti-HIV Agents Antineoplastic Agents Butanones Cyclization Cyclohexanes Cyclopentanes Cyclopropanes Dideoxynucleosides Glyceraldehyde Glycosides Humans Molecular Conformation Nucleosides Stereoisomerism The recent advances in the chemistry of carbocyclic nucleosides focused on different synthetic approaches that lead to optically pure products as well as a comprehensive overview of their biological properties are discussed. In the latter aspect, molecular recognition of enzymes of pharmacological importance such as: reverse transcriptase, adenosine deaminase, thymidine kinase, DNA cytosine-C5 methyl transferase, S-adenosylhomocysteine hydrolase, etc are considered. The role of conformation and puckering of the glycon moiety in modulating the biological activity and also the use of carbanucleosides as building blocks to prepare oligonucleotides are carefully illustrated. Fil:Rodríguez, J.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Comin, M.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2003 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13895575_v3_n2_p95_Rodriguez http://hdl.handle.net/20.500.12110/paper_13895575_v3_n2_p95_Rodriguez
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	2',3' dideoxynucleoside derivative alkanone anti human immunodeficiency virus agent antineoplastic agent carbovir cyclohexane derivative cyclopentane derivative cyclopropane derivative glyceraldehyde glycoside nucleoside chemistry conformation cyclization human review stereoisomerism synthesis Anti-HIV Agents Antineoplastic Agents Butanones Cyclization Cyclohexanes Cyclopentanes Cyclopropanes Dideoxynucleosides Glyceraldehyde Glycosides Humans Molecular Conformation Nucleosides Stereoisomerism
spellingShingle	2',3' dideoxynucleoside derivative alkanone anti human immunodeficiency virus agent antineoplastic agent carbovir cyclohexane derivative cyclopentane derivative cyclopropane derivative glyceraldehyde glycoside nucleoside chemistry conformation cyclization human review stereoisomerism synthesis Anti-HIV Agents Antineoplastic Agents Butanones Cyclization Cyclohexanes Cyclopentanes Cyclopropanes Dideoxynucleosides Glyceraldehyde Glycosides Humans Molecular Conformation Nucleosides Stereoisomerism Rodríguez, Juan Bautista Comin, María Julieta New progresses in the enantioselective synthesis and biological properties of carbocyclic nucleosides.
topic_facet	2',3' dideoxynucleoside derivative alkanone anti human immunodeficiency virus agent antineoplastic agent carbovir cyclohexane derivative cyclopentane derivative cyclopropane derivative glyceraldehyde glycoside nucleoside chemistry conformation cyclization human review stereoisomerism synthesis Anti-HIV Agents Antineoplastic Agents Butanones Cyclization Cyclohexanes Cyclopentanes Cyclopropanes Dideoxynucleosides Glyceraldehyde Glycosides Humans Molecular Conformation Nucleosides Stereoisomerism
description	The recent advances in the chemistry of carbocyclic nucleosides focused on different synthetic approaches that lead to optically pure products as well as a comprehensive overview of their biological properties are discussed. In the latter aspect, molecular recognition of enzymes of pharmacological importance such as: reverse transcriptase, adenosine deaminase, thymidine kinase, DNA cytosine-C5 methyl transferase, S-adenosylhomocysteine hydrolase, etc are considered. The role of conformation and puckering of the glycon moiety in modulating the biological activity and also the use of carbanucleosides as building blocks to prepare oligonucleotides are carefully illustrated.
author	Rodríguez, Juan Bautista Comin, María Julieta
author_facet	Rodríguez, Juan Bautista Comin, María Julieta
author_sort	Rodríguez, Juan Bautista
title	New progresses in the enantioselective synthesis and biological properties of carbocyclic nucleosides.
title_short	New progresses in the enantioselective synthesis and biological properties of carbocyclic nucleosides.
title_full	New progresses in the enantioselective synthesis and biological properties of carbocyclic nucleosides.
title_fullStr	New progresses in the enantioselective synthesis and biological properties of carbocyclic nucleosides.
title_full_unstemmed	New progresses in the enantioselective synthesis and biological properties of carbocyclic nucleosides.
title_sort	new progresses in the enantioselective synthesis and biological properties of carbocyclic nucleosides.
publishDate	2003
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13895575_v3_n2_p95_Rodriguez http://hdl.handle.net/20.500.12110/paper_13895575_v3_n2_p95_Rodriguez
work_keys_str_mv	AT rodriguezjuanbautista newprogressesintheenantioselectivesynthesisandbiologicalpropertiesofcarbocyclicnucleosides AT cominmariajulieta newprogressesintheenantioselectivesynthesisandbiologicalpropertiesofcarbocyclicnucleosides
_version_	1768543815652605952

New progresses in the enantioselective synthesis and biological properties of carbocyclic nucleosides.

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