Time course of hexachlorobenzene-induced alterations of lipid metabolism and their relation to porphyria
A great deal of information concerning the effects of hexachlorobenzene on the haem metabolic pathway has been obtained but little is known about the effects of the drug on lipid metabolism, Consequently, the time course of phospholipid metabolism alteration caused by this xenobiotic was evaluated a...
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1997
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paper:paper_13572725_v29_n2_p335_BilliDeCatabbi2025-07-30T18:47:02Z Time course of hexachlorobenzene-induced alterations of lipid metabolism and their relation to porphyria Billi de Catabbi, Silvia Cristina Minutolo, Carolina San Martín de Viale, Leonor Carmen Hexachlorobenzene Lipid peroxidation Phospholipid Porphyria Porphyrins hexachlorobenzene phospholipid porphyrin uroporphyrinogen decarboxylase animal model article controlled study female lipid peroxidation nonhuman phospholipid metabolism porphyria porphyrin metabolism rat Animals Female Fungicides, Industrial Hexachlorobenzene Lipid Metabolism Lipid Peroxidation Porphyrias Rats Rats, Wistar Animalia Rattus norvegicus A great deal of information concerning the effects of hexachlorobenzene on the haem metabolic pathway has been obtained but little is known about the effects of the drug on lipid metabolism, Consequently, the time course of phospholipid metabolism alteration caused by this xenobiotic was evaluated as related to changes in porphyrin metabolism with the aim to understand better the interregulation of both metabolisms. Female Wistar rats were treated with HCB (1 g/kg) over a 1-8 week period. Individual phospholipid content, [32P] incorporation, total lipid content, lipid peroxidation, uroporphyrinogen decarboxylase activity, its inhibitor generation and porphyrin content, were the parameters measured in the liver of treated rats. Phospholipid metabolism - with the exception of sphingomyelin-presents a biphasic behaviour, in both the endogenous contents and de novo synthesis. The turning point between both phases is the time at which levels of porphyrin and conjugated dienes increase, the latter compounds being involved in oxidative processes. On the other hand, sphingomyelin decreases continuously during the 8 weeks of treatment. It mas also found that the malondialdehyde content increased during the early stages. The time sequence for haem metabolism parameters showed that the accumulation of porphyrins occurs after the decrease in uroporphyrinogen decarboxylase activity and the enzyme inhibitor formation, which are early events (first and second weeks). Porphyrins could not by themselves exacerbate uroporphyrinogen decarboxylase impairment or inhibitor generation. This study shows that hexachlorobenzene alters simultaneously phospholipid and porphyrin metabolisms from the early stages, and generates an oxidative environment that favours porphyrinogens and lipid oxidation at later stages. So, this oxidative environment links the alterations on both metabolisms. Fil:Billi De Catabbi, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Minutolo, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:San Martin De Viale, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1997 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13572725_v29_n2_p335_BilliDeCatabbi http://hdl.handle.net/20.500.12110/paper_13572725_v29_n2_p335_BilliDeCatabbi |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Hexachlorobenzene Lipid peroxidation Phospholipid Porphyria Porphyrins hexachlorobenzene phospholipid porphyrin uroporphyrinogen decarboxylase animal model article controlled study female lipid peroxidation nonhuman phospholipid metabolism porphyria porphyrin metabolism rat Animals Female Fungicides, Industrial Hexachlorobenzene Lipid Metabolism Lipid Peroxidation Porphyrias Rats Rats, Wistar Animalia Rattus norvegicus |
| spellingShingle |
Hexachlorobenzene Lipid peroxidation Phospholipid Porphyria Porphyrins hexachlorobenzene phospholipid porphyrin uroporphyrinogen decarboxylase animal model article controlled study female lipid peroxidation nonhuman phospholipid metabolism porphyria porphyrin metabolism rat Animals Female Fungicides, Industrial Hexachlorobenzene Lipid Metabolism Lipid Peroxidation Porphyrias Rats Rats, Wistar Animalia Rattus norvegicus Billi de Catabbi, Silvia Cristina Minutolo, Carolina San Martín de Viale, Leonor Carmen Time course of hexachlorobenzene-induced alterations of lipid metabolism and their relation to porphyria |
| topic_facet |
Hexachlorobenzene Lipid peroxidation Phospholipid Porphyria Porphyrins hexachlorobenzene phospholipid porphyrin uroporphyrinogen decarboxylase animal model article controlled study female lipid peroxidation nonhuman phospholipid metabolism porphyria porphyrin metabolism rat Animals Female Fungicides, Industrial Hexachlorobenzene Lipid Metabolism Lipid Peroxidation Porphyrias Rats Rats, Wistar Animalia Rattus norvegicus |
| description |
A great deal of information concerning the effects of hexachlorobenzene on the haem metabolic pathway has been obtained but little is known about the effects of the drug on lipid metabolism, Consequently, the time course of phospholipid metabolism alteration caused by this xenobiotic was evaluated as related to changes in porphyrin metabolism with the aim to understand better the interregulation of both metabolisms. Female Wistar rats were treated with HCB (1 g/kg) over a 1-8 week period. Individual phospholipid content, [32P] incorporation, total lipid content, lipid peroxidation, uroporphyrinogen decarboxylase activity, its inhibitor generation and porphyrin content, were the parameters measured in the liver of treated rats. Phospholipid metabolism - with the exception of sphingomyelin-presents a biphasic behaviour, in both the endogenous contents and de novo synthesis. The turning point between both phases is the time at which levels of porphyrin and conjugated dienes increase, the latter compounds being involved in oxidative processes. On the other hand, sphingomyelin decreases continuously during the 8 weeks of treatment. It mas also found that the malondialdehyde content increased during the early stages. The time sequence for haem metabolism parameters showed that the accumulation of porphyrins occurs after the decrease in uroporphyrinogen decarboxylase activity and the enzyme inhibitor formation, which are early events (first and second weeks). Porphyrins could not by themselves exacerbate uroporphyrinogen decarboxylase impairment or inhibitor generation. This study shows that hexachlorobenzene alters simultaneously phospholipid and porphyrin metabolisms from the early stages, and generates an oxidative environment that favours porphyrinogens and lipid oxidation at later stages. So, this oxidative environment links the alterations on both metabolisms. |
| author |
Billi de Catabbi, Silvia Cristina Minutolo, Carolina San Martín de Viale, Leonor Carmen |
| author_facet |
Billi de Catabbi, Silvia Cristina Minutolo, Carolina San Martín de Viale, Leonor Carmen |
| author_sort |
Billi de Catabbi, Silvia Cristina |
| title |
Time course of hexachlorobenzene-induced alterations of lipid metabolism and their relation to porphyria |
| title_short |
Time course of hexachlorobenzene-induced alterations of lipid metabolism and their relation to porphyria |
| title_full |
Time course of hexachlorobenzene-induced alterations of lipid metabolism and their relation to porphyria |
| title_fullStr |
Time course of hexachlorobenzene-induced alterations of lipid metabolism and their relation to porphyria |
| title_full_unstemmed |
Time course of hexachlorobenzene-induced alterations of lipid metabolism and their relation to porphyria |
| title_sort |
time course of hexachlorobenzene-induced alterations of lipid metabolism and their relation to porphyria |
| publishDate |
1997 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13572725_v29_n2_p335_BilliDeCatabbi http://hdl.handle.net/20.500.12110/paper_13572725_v29_n2_p335_BilliDeCatabbi |
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AT billidecatabbisilviacristina timecourseofhexachlorobenzeneinducedalterationsoflipidmetabolismandtheirrelationtoporphyria AT minutolocarolina timecourseofhexachlorobenzeneinducedalterationsoflipidmetabolismandtheirrelationtoporphyria AT sanmartindevialeleonorcarmen timecourseofhexachlorobenzeneinducedalterationsoflipidmetabolismandtheirrelationtoporphyria |
| _version_ |
1840320720893116416 |