Involvement of galectin-1 in reproduction: Past, present and future
background: After recognition of its pivotal contribution to fetomaternal tolerance, the study of galectin-1 (gal-1) functions in the context of pregnancy became an attractive topic in reproductive medicine. Despite considerable advances in the understanding of the immuno- and growth-regulatory prop...
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2014
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paper:paper_13554786_v20_n2_p175_Barrientos2023-06-08T16:11:09Z Involvement of galectin-1 in reproduction: Past, present and future Angiogenesis Cancer Galectin-1 Pregnancy Progesterone angiogenesis cancer galectin-1 pregnancy progesterone Adaptation, Physiological Animals Female Galectin 1 Genital Neoplasms, Female Genitalia, Female Humans Immune Tolerance Mice Neovascularization, Physiologic Pregnancy Pregnancy Complications Reproduction Signal Transduction Trophoblasts background: After recognition of its pivotal contribution to fetomaternal tolerance, the study of galectin-1 (gal-1) functions in the context of pregnancy became an attractive topic in reproductive medicine. Despite considerable advances in the understanding of the immuno- and growth-regulatory properties of gal-1 at the fetal-maternal interface, many functional aspects of this lectin in reproduction are only emerging. methods: The published literature was searched using Pubmed focusing on gal-1 signalling and functional properties at the maternal-fetal interface, including data on its implication in pregnancy disorders and malignancies of the female reproductive system. Papers discussing animal and human studies were included. results: This review provides an overview of gal-1 functions during pregnancy, such as modulation of maternal immune responses and roles in embryo implantation and placentation.We also emphasize the role of gal-1 in key regulatory processes, including trophoblast migration, invasion, syncytiumformation and expression of non-classical MHC class I molecules (HLA-G). In addition, we argue in favour of gal-1 pro-angiogenic properties, as observed in tumourigenesis and other pathological settings, and its implication in the angiogenesis process associated with early gestation. conclusion: The involvement of gal-1 in the regulation of different processes during the establishment, development and maintenance of pregnancy could be described as unique. Gal-1 has emerged as an important lectin with major functions in pregnancy. © The Author 2013. 2014 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13554786_v20_n2_p175_Barrientos http://hdl.handle.net/20.500.12110/paper_13554786_v20_n2_p175_Barrientos |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Angiogenesis Cancer Galectin-1 Pregnancy Progesterone angiogenesis cancer galectin-1 pregnancy progesterone Adaptation, Physiological Animals Female Galectin 1 Genital Neoplasms, Female Genitalia, Female Humans Immune Tolerance Mice Neovascularization, Physiologic Pregnancy Pregnancy Complications Reproduction Signal Transduction Trophoblasts |
| spellingShingle |
Angiogenesis Cancer Galectin-1 Pregnancy Progesterone angiogenesis cancer galectin-1 pregnancy progesterone Adaptation, Physiological Animals Female Galectin 1 Genital Neoplasms, Female Genitalia, Female Humans Immune Tolerance Mice Neovascularization, Physiologic Pregnancy Pregnancy Complications Reproduction Signal Transduction Trophoblasts Involvement of galectin-1 in reproduction: Past, present and future |
| topic_facet |
Angiogenesis Cancer Galectin-1 Pregnancy Progesterone angiogenesis cancer galectin-1 pregnancy progesterone Adaptation, Physiological Animals Female Galectin 1 Genital Neoplasms, Female Genitalia, Female Humans Immune Tolerance Mice Neovascularization, Physiologic Pregnancy Pregnancy Complications Reproduction Signal Transduction Trophoblasts |
| description |
background: After recognition of its pivotal contribution to fetomaternal tolerance, the study of galectin-1 (gal-1) functions in the context of pregnancy became an attractive topic in reproductive medicine. Despite considerable advances in the understanding of the immuno- and growth-regulatory properties of gal-1 at the fetal-maternal interface, many functional aspects of this lectin in reproduction are only emerging. methods: The published literature was searched using Pubmed focusing on gal-1 signalling and functional properties at the maternal-fetal interface, including data on its implication in pregnancy disorders and malignancies of the female reproductive system. Papers discussing animal and human studies were included. results: This review provides an overview of gal-1 functions during pregnancy, such as modulation of maternal immune responses and roles in embryo implantation and placentation.We also emphasize the role of gal-1 in key regulatory processes, including trophoblast migration, invasion, syncytiumformation and expression of non-classical MHC class I molecules (HLA-G). In addition, we argue in favour of gal-1 pro-angiogenic properties, as observed in tumourigenesis and other pathological settings, and its implication in the angiogenesis process associated with early gestation. conclusion: The involvement of gal-1 in the regulation of different processes during the establishment, development and maintenance of pregnancy could be described as unique. Gal-1 has emerged as an important lectin with major functions in pregnancy. © The Author 2013. |
| title |
Involvement of galectin-1 in reproduction: Past, present and future |
| title_short |
Involvement of galectin-1 in reproduction: Past, present and future |
| title_full |
Involvement of galectin-1 in reproduction: Past, present and future |
| title_fullStr |
Involvement of galectin-1 in reproduction: Past, present and future |
| title_full_unstemmed |
Involvement of galectin-1 in reproduction: Past, present and future |
| title_sort |
involvement of galectin-1 in reproduction: past, present and future |
| publishDate |
2014 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13554786_v20_n2_p175_Barrientos http://hdl.handle.net/20.500.12110/paper_13554786_v20_n2_p175_Barrientos |
| _version_ |
1768542752556974080 |