New antibacterials for the treatment of toxoplasmosis; A patent review
Introduction : Toxoplasma gondii is an opportunistic protozoan parasite responsible for toxoplasmosis. T. gondii is able to infect a wide range of hosts, particularly humans and warm-blooded animals. Toxoplasmosis can be considered as one of the most prevalent parasitic diseases affecting close to o...
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paper:paper_13543776_v22_n3_p311_Rodriguez2023-06-08T16:11:06Z New antibacterials for the treatment of toxoplasmosis; A patent review Rodríguez, Juan Bautista Szajnman, Sergio Hernán Calcium-dependent protein kinases Dihydrofolate reductase Farnesyl pyrophosphate synthase Macrolides Squalene synthase T. gondii adenosine kinase T. gondii histone deacetylase Toxoplasma gondii Toxoplasmosis 1 alkyl bisphosphonate derivative 1 amino bisphosphonate derivative 1 hydroxy bisphosphonate derivative 1h benzo[d]imidazol 2(3h) one 4 phenoxyphenoxy ethyl thiocyanate 6 n benzyladenosine alendronic acid alpha fluoro 1,1 bisphosphonate derivative antiinfective agent apicidin artemether artemisin artemisinin derivative artemisone azasterol derivative azithromycin bisphosphonic acid derivative deoxyartemisinin erythromycin ibandronic acid macrolide n[4 [(2 amino 6 methyl 4 oxo 3,4 dihydrothieno[2,3 d]pyrimidin 5 yl)sulfanyl]benzoyl]glutamicacid pamidronic acid piritrexim pyrimethamine sulfadiazine risedronic acid squalene synthase inhibitor tacrolimus trimethoprim unclassified drug unindexed drug wc 9 amino acid sequence antiproliferative activity brain malaria cell death cell invasion drug mechanism drug potentiation drug structure drug targeting enzyme inhibition life cycle nonhuman nucleic acid synthesis osteoporosis review Toxoplasma gondii toxoplasmosis Animals Antiprotozoal Agents Drug Design Female Humans Immunocompromised Host Molecular Targeted Therapy Patents as Topic Pregnancy Toxoplasma Toxoplasmosis Toxoplasmosis, Animal Introduction : Toxoplasma gondii is an opportunistic protozoan parasite responsible for toxoplasmosis. T. gondii is able to infect a wide range of hosts, particularly humans and warm-blooded animals. Toxoplasmosis can be considered as one of the most prevalent parasitic diseases affecting close to one billion people worldwide, but its current chemotherapy is still deficient and is only effective in the acute phase of the disease. Areas covered : This review covers different approaches to toxoplasmosis chemotherapy focused on the metabolic differences between the host and the parasite. Selective action on different targets such as the isoprenoid pathway, dihydrofolate reductase, T. gondii adenosine kinase, different antibacterials, T. gondii histone deacetylase and calcium-dependent protein kinases is discussed. Expert opinion : A new and safe chemotherapy is needed, as T. gondii causes serious morbidity and mortality in pregnant women and immunodeficient patients undergoing chemotherapy. A particular drawback of the available treatments is the lack of efficacy against the tissue cyst of the parasite. During this review a broad scope of several attractive targets for drug design have been presented. In this context, the isoprenoid pathway, dihydrofolate reductase, T. gondii histone deacetylase are promising molecular targets. © 2012 Informa UK, Ltd. Fil:Rodriguez, J.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Szajnman, S.H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2012 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13543776_v22_n3_p311_Rodriguez http://hdl.handle.net/20.500.12110/paper_13543776_v22_n3_p311_Rodriguez |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Calcium-dependent protein kinases Dihydrofolate reductase Farnesyl pyrophosphate synthase Macrolides Squalene synthase T. gondii adenosine kinase T. gondii histone deacetylase Toxoplasma gondii Toxoplasmosis 1 alkyl bisphosphonate derivative 1 amino bisphosphonate derivative 1 hydroxy bisphosphonate derivative 1h benzo[d]imidazol 2(3h) one 4 phenoxyphenoxy ethyl thiocyanate 6 n benzyladenosine alendronic acid alpha fluoro 1,1 bisphosphonate derivative antiinfective agent apicidin artemether artemisin artemisinin derivative artemisone azasterol derivative azithromycin bisphosphonic acid derivative deoxyartemisinin erythromycin ibandronic acid macrolide n[4 [(2 amino 6 methyl 4 oxo 3,4 dihydrothieno[2,3 d]pyrimidin 5 yl)sulfanyl]benzoyl]glutamicacid pamidronic acid piritrexim pyrimethamine sulfadiazine risedronic acid squalene synthase inhibitor tacrolimus trimethoprim unclassified drug unindexed drug wc 9 amino acid sequence antiproliferative activity brain malaria cell death cell invasion drug mechanism drug potentiation drug structure drug targeting enzyme inhibition life cycle nonhuman nucleic acid synthesis osteoporosis review Toxoplasma gondii toxoplasmosis Animals Antiprotozoal Agents Drug Design Female Humans Immunocompromised Host Molecular Targeted Therapy Patents as Topic Pregnancy Toxoplasma Toxoplasmosis Toxoplasmosis, Animal |
| spellingShingle |
Calcium-dependent protein kinases Dihydrofolate reductase Farnesyl pyrophosphate synthase Macrolides Squalene synthase T. gondii adenosine kinase T. gondii histone deacetylase Toxoplasma gondii Toxoplasmosis 1 alkyl bisphosphonate derivative 1 amino bisphosphonate derivative 1 hydroxy bisphosphonate derivative 1h benzo[d]imidazol 2(3h) one 4 phenoxyphenoxy ethyl thiocyanate 6 n benzyladenosine alendronic acid alpha fluoro 1,1 bisphosphonate derivative antiinfective agent apicidin artemether artemisin artemisinin derivative artemisone azasterol derivative azithromycin bisphosphonic acid derivative deoxyartemisinin erythromycin ibandronic acid macrolide n[4 [(2 amino 6 methyl 4 oxo 3,4 dihydrothieno[2,3 d]pyrimidin 5 yl)sulfanyl]benzoyl]glutamicacid pamidronic acid piritrexim pyrimethamine sulfadiazine risedronic acid squalene synthase inhibitor tacrolimus trimethoprim unclassified drug unindexed drug wc 9 amino acid sequence antiproliferative activity brain malaria cell death cell invasion drug mechanism drug potentiation drug structure drug targeting enzyme inhibition life cycle nonhuman nucleic acid synthesis osteoporosis review Toxoplasma gondii toxoplasmosis Animals Antiprotozoal Agents Drug Design Female Humans Immunocompromised Host Molecular Targeted Therapy Patents as Topic Pregnancy Toxoplasma Toxoplasmosis Toxoplasmosis, Animal Rodríguez, Juan Bautista Szajnman, Sergio Hernán New antibacterials for the treatment of toxoplasmosis; A patent review |
| topic_facet |
Calcium-dependent protein kinases Dihydrofolate reductase Farnesyl pyrophosphate synthase Macrolides Squalene synthase T. gondii adenosine kinase T. gondii histone deacetylase Toxoplasma gondii Toxoplasmosis 1 alkyl bisphosphonate derivative 1 amino bisphosphonate derivative 1 hydroxy bisphosphonate derivative 1h benzo[d]imidazol 2(3h) one 4 phenoxyphenoxy ethyl thiocyanate 6 n benzyladenosine alendronic acid alpha fluoro 1,1 bisphosphonate derivative antiinfective agent apicidin artemether artemisin artemisinin derivative artemisone azasterol derivative azithromycin bisphosphonic acid derivative deoxyartemisinin erythromycin ibandronic acid macrolide n[4 [(2 amino 6 methyl 4 oxo 3,4 dihydrothieno[2,3 d]pyrimidin 5 yl)sulfanyl]benzoyl]glutamicacid pamidronic acid piritrexim pyrimethamine sulfadiazine risedronic acid squalene synthase inhibitor tacrolimus trimethoprim unclassified drug unindexed drug wc 9 amino acid sequence antiproliferative activity brain malaria cell death cell invasion drug mechanism drug potentiation drug structure drug targeting enzyme inhibition life cycle nonhuman nucleic acid synthesis osteoporosis review Toxoplasma gondii toxoplasmosis Animals Antiprotozoal Agents Drug Design Female Humans Immunocompromised Host Molecular Targeted Therapy Patents as Topic Pregnancy Toxoplasma Toxoplasmosis Toxoplasmosis, Animal |
| description |
Introduction : Toxoplasma gondii is an opportunistic protozoan parasite responsible for toxoplasmosis. T. gondii is able to infect a wide range of hosts, particularly humans and warm-blooded animals. Toxoplasmosis can be considered as one of the most prevalent parasitic diseases affecting close to one billion people worldwide, but its current chemotherapy is still deficient and is only effective in the acute phase of the disease. Areas covered : This review covers different approaches to toxoplasmosis chemotherapy focused on the metabolic differences between the host and the parasite. Selective action on different targets such as the isoprenoid pathway, dihydrofolate reductase, T. gondii adenosine kinase, different antibacterials, T. gondii histone deacetylase and calcium-dependent protein kinases is discussed. Expert opinion : A new and safe chemotherapy is needed, as T. gondii causes serious morbidity and mortality in pregnant women and immunodeficient patients undergoing chemotherapy. A particular drawback of the available treatments is the lack of efficacy against the tissue cyst of the parasite. During this review a broad scope of several attractive targets for drug design have been presented. In this context, the isoprenoid pathway, dihydrofolate reductase, T. gondii histone deacetylase are promising molecular targets. © 2012 Informa UK, Ltd. |
| author |
Rodríguez, Juan Bautista Szajnman, Sergio Hernán |
| author_facet |
Rodríguez, Juan Bautista Szajnman, Sergio Hernán |
| author_sort |
Rodríguez, Juan Bautista |
| title |
New antibacterials for the treatment of toxoplasmosis; A patent review |
| title_short |
New antibacterials for the treatment of toxoplasmosis; A patent review |
| title_full |
New antibacterials for the treatment of toxoplasmosis; A patent review |
| title_fullStr |
New antibacterials for the treatment of toxoplasmosis; A patent review |
| title_full_unstemmed |
New antibacterials for the treatment of toxoplasmosis; A patent review |
| title_sort |
new antibacterials for the treatment of toxoplasmosis; a patent review |
| publishDate |
2012 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13543776_v22_n3_p311_Rodriguez http://hdl.handle.net/20.500.12110/paper_13543776_v22_n3_p311_Rodriguez |
| work_keys_str_mv |
AT rodriguezjuanbautista newantibacterialsforthetreatmentoftoxoplasmosisapatentreview AT szajnmansergiohernan newantibacterialsforthetreatmentoftoxoplasmosisapatentreview |
| _version_ |
1768543861357936640 |