Photophysical properties of Zn(II) phthalocyaninates incorporated into liposomes
Amphiphilic phthalocyanines are used as potential photosensitizers in photodynamic therapy. The low water solubility of most of these dyes is the reason that different kinds of vehicles are employed as endogenous carriers. Due to the photophysical inactivity of the phthalocyanine aggregates, it is i...
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2002
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10884246_v6_n2_p122_Rodriguez http://hdl.handle.net/20.500.12110/paper_10884246_v6_n2_p122_Rodriguez |
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paper:paper_10884246_v6_n2_p122_Rodriguez2023-06-08T16:06:12Z Photophysical properties of Zn(II) phthalocyaninates incorporated into liposomes Association constant Fluorescence quantum yields Liposomes PDT Zinc phthalocyanine dimyristoylphosphatidylcholine liposome photosensitizing agent phthalocyanine derivative unclassified drug zinc derivative zinc phthalocyaninate article binding affinity chemical structure drug solubility fluorescence spectroscopy lipophilicity photodynamic therapy Amphiphilic phthalocyanines are used as potential photosensitizers in photodynamic therapy. The low water solubility of most of these dyes is the reason that different kinds of vehicles are employed as endogenous carriers. Due to the photophysical inactivity of the phthalocyanine aggregates, it is important to improve their solubility in order to study dyes in solid tumor models. On the other hand, the photodynamic therapy activity depends on the location of phthalocyanines in the cell and the interaction of cellular components. In this work, the photophysical properties of tetrasubstituted Zn(II) phthalocyanines with different lipophilic properties are incorporated into liposomes of L-α-dimyristoylphosphatidylcholine (DMPC). The fluorescence quantum yields, the association constants and their localization in the membranes are reported. Copyright © 2002 Society of Porphyrins & Phthalocyanines. 2002 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10884246_v6_n2_p122_Rodriguez http://hdl.handle.net/20.500.12110/paper_10884246_v6_n2_p122_Rodriguez |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Association constant Fluorescence quantum yields Liposomes PDT Zinc phthalocyanine dimyristoylphosphatidylcholine liposome photosensitizing agent phthalocyanine derivative unclassified drug zinc derivative zinc phthalocyaninate article binding affinity chemical structure drug solubility fluorescence spectroscopy lipophilicity photodynamic therapy |
| spellingShingle |
Association constant Fluorescence quantum yields Liposomes PDT Zinc phthalocyanine dimyristoylphosphatidylcholine liposome photosensitizing agent phthalocyanine derivative unclassified drug zinc derivative zinc phthalocyaninate article binding affinity chemical structure drug solubility fluorescence spectroscopy lipophilicity photodynamic therapy Photophysical properties of Zn(II) phthalocyaninates incorporated into liposomes |
| topic_facet |
Association constant Fluorescence quantum yields Liposomes PDT Zinc phthalocyanine dimyristoylphosphatidylcholine liposome photosensitizing agent phthalocyanine derivative unclassified drug zinc derivative zinc phthalocyaninate article binding affinity chemical structure drug solubility fluorescence spectroscopy lipophilicity photodynamic therapy |
| description |
Amphiphilic phthalocyanines are used as potential photosensitizers in photodynamic therapy. The low water solubility of most of these dyes is the reason that different kinds of vehicles are employed as endogenous carriers. Due to the photophysical inactivity of the phthalocyanine aggregates, it is important to improve their solubility in order to study dyes in solid tumor models. On the other hand, the photodynamic therapy activity depends on the location of phthalocyanines in the cell and the interaction of cellular components. In this work, the photophysical properties of tetrasubstituted Zn(II) phthalocyanines with different lipophilic properties are incorporated into liposomes of L-α-dimyristoylphosphatidylcholine (DMPC). The fluorescence quantum yields, the association constants and their localization in the membranes are reported. Copyright © 2002 Society of Porphyrins & Phthalocyanines. |
| title |
Photophysical properties of Zn(II) phthalocyaninates incorporated into liposomes |
| title_short |
Photophysical properties of Zn(II) phthalocyaninates incorporated into liposomes |
| title_full |
Photophysical properties of Zn(II) phthalocyaninates incorporated into liposomes |
| title_fullStr |
Photophysical properties of Zn(II) phthalocyaninates incorporated into liposomes |
| title_full_unstemmed |
Photophysical properties of Zn(II) phthalocyaninates incorporated into liposomes |
| title_sort |
photophysical properties of zn(ii) phthalocyaninates incorporated into liposomes |
| publishDate |
2002 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10884246_v6_n2_p122_Rodriguez http://hdl.handle.net/20.500.12110/paper_10884246_v6_n2_p122_Rodriguez |
| _version_ |
1768546265002409984 |