Preclinical photodynamic therapy research in Spain 4: Cytoskeleton and adhesion complexes of cultured tumor cells as targets of photosensitizers

Tumor cell death induced by photodynamic therapy (PDT) with different photosensitizers (PSs) is due to the selective damage of several membranous organelles including mitochondria, lysosomes and Golgi apparatus. Other cell structures such as the cytoskeleton (CSK) (microtubules, actin microfilaments...

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Guardado en:
Detalles Bibliográficos
Publicado: 2009
Materias:
Cell adhesion components
Cytoskeleton
Microfilaments
Microtubules
Photodynamic therapy
Resistant cells to photodynamic therapy
Tumor cells
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10884246_v13_n4-5_p552_SanzRodriguez
http://hdl.handle.net/20.500.12110/paper_10884246_v13_n4-5_p552_SanzRodriguez
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_10884246_v13_n4-5_p552_SanzRodriguez
record_format dspace
spelling paper:paper_10884246_v13_n4-5_p552_SanzRodriguez2023-06-08T16:06:11Z Preclinical photodynamic therapy research in Spain 4: Cytoskeleton and adhesion complexes of cultured tumor cells as targets of photosensitizers Cell adhesion components Cytoskeleton Microfilaments Microtubules Photodynamic therapy Resistant cells to photodynamic therapy Tumor cells Tumor cell death induced by photodynamic therapy (PDT) with different photosensitizers (PSs) is due to the selective damage of several membranous organelles including mitochondria, lysosomes and Golgi apparatus. Other cell structures such as the cytoskeleton (CSK) (microtubules, actin microfilaments and cytokeratin intermediate filaments) and the cell adhesion components (cadherins and integrins) are also implicated in cell death induced by PSs. CSK and adhesion components are responsible for many cellular functions such as the maintenance of morphology, motility, division and adhesion, all of them of fundamental importance for growth and dissemination of tumors. Therefore, they are considered very important targets for anticancer therapies, including PDT. In addition, similarly to the rest of the anticancer therapies, PDT often leaves a significant number of surviving tumor cells. The reorganization of CSK as well as the adhesion proteins in the PDT resistant cells affect their invasive migratory capabilities. Taking into account all these features, both CSK and adhesion proteins are crucial targets of PDT. © 2009 World Scientific Publishing Company. 2009 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10884246_v13_n4-5_p552_SanzRodriguez http://hdl.handle.net/20.500.12110/paper_10884246_v13_n4-5_p552_SanzRodriguez
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Cell adhesion components
Cytoskeleton
Microfilaments
Microtubules
Photodynamic therapy
Resistant cells to photodynamic therapy
Tumor cells
spellingShingle Cell adhesion components
Cytoskeleton
Microfilaments
Microtubules
Photodynamic therapy
Resistant cells to photodynamic therapy
Tumor cells
Preclinical photodynamic therapy research in Spain 4: Cytoskeleton and adhesion complexes of cultured tumor cells as targets of photosensitizers
topic_facet Cell adhesion components
Cytoskeleton
Microfilaments
Microtubules
Photodynamic therapy
Resistant cells to photodynamic therapy
Tumor cells
description Tumor cell death induced by photodynamic therapy (PDT) with different photosensitizers (PSs) is due to the selective damage of several membranous organelles including mitochondria, lysosomes and Golgi apparatus. Other cell structures such as the cytoskeleton (CSK) (microtubules, actin microfilaments and cytokeratin intermediate filaments) and the cell adhesion components (cadherins and integrins) are also implicated in cell death induced by PSs. CSK and adhesion components are responsible for many cellular functions such as the maintenance of morphology, motility, division and adhesion, all of them of fundamental importance for growth and dissemination of tumors. Therefore, they are considered very important targets for anticancer therapies, including PDT. In addition, similarly to the rest of the anticancer therapies, PDT often leaves a significant number of surviving tumor cells. The reorganization of CSK as well as the adhesion proteins in the PDT resistant cells affect their invasive migratory capabilities. Taking into account all these features, both CSK and adhesion proteins are crucial targets of PDT. © 2009 World Scientific Publishing Company.
title Preclinical photodynamic therapy research in Spain 4: Cytoskeleton and adhesion complexes of cultured tumor cells as targets of photosensitizers
title_short Preclinical photodynamic therapy research in Spain 4: Cytoskeleton and adhesion complexes of cultured tumor cells as targets of photosensitizers
title_full Preclinical photodynamic therapy research in Spain 4: Cytoskeleton and adhesion complexes of cultured tumor cells as targets of photosensitizers
title_fullStr Preclinical photodynamic therapy research in Spain 4: Cytoskeleton and adhesion complexes of cultured tumor cells as targets of photosensitizers
title_full_unstemmed Preclinical photodynamic therapy research in Spain 4: Cytoskeleton and adhesion complexes of cultured tumor cells as targets of photosensitizers
title_sort preclinical photodynamic therapy research in spain 4: cytoskeleton and adhesion complexes of cultured tumor cells as targets of photosensitizers
publishDate 2009
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10884246_v13_n4-5_p552_SanzRodriguez
http://hdl.handle.net/20.500.12110/paper_10884246_v13_n4-5_p552_SanzRodriguez
_version_ 1768544925054402560

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