Effect of aggregation of a cationic phthalocyanine in micelles and in the presence of human serum albumin

The photophysical properties of tetrakis(1,1-dimethyl-2-trimethylammonium) ethylphthalocyaninato zinc(II) tetraiodide (I) - a water-soluble cationic phthalocyanine - are presented in the presence of human serum albumin (HSA) and in micelles of sodium dodecylsulfate (SDS) and hexadecyltrimethylammoni...

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Detalles Bibliográficos
Publicado: 2006
Materias:
Aggregation
Albumin
Hydrophobic interactions
Micelles
Tetrakis(1,1- dimethyl-2-trimethylammonium)ethylphthalocyaninato zinc(II) tetraiodide
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10884246_v10_n1_p33_Rodriguez
http://hdl.handle.net/20.500.12110/paper_10884246_v10_n1_p33_Rodriguez
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_10884246_v10_n1_p33_Rodriguez
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spelling paper:paper_10884246_v10_n1_p33_Rodriguez2023-06-08T16:06:11Z Effect of aggregation of a cationic phthalocyanine in micelles and in the presence of human serum albumin Aggregation Albumin Hydrophobic interactions Micelles Tetrakis(1,1- dimethyl-2-trimethylammonium)ethylphthalocyaninato zinc(II) tetraiodide The photophysical properties of tetrakis(1,1-dimethyl-2-trimethylammonium) ethylphthalocyaninato zinc(II) tetraiodide (I) - a water-soluble cationic phthalocyanine - are presented in the presence of human serum albumin (HSA) and in micelles of sodium dodecylsulfate (SDS) and hexadecyltrimethylammonium chloride (CTAC). Spectrophotometric measurements showed that the surfactants SDS and CTAC induce monomerization of I, although the latter less efficiently than the former. This effect is less pronounced in the presence of HSA. The strength of this effect is evaluated through dimerization constants, which are K d = (5 ± 1) × 105 M-1 in SDS, (1.5 ± 0.5) × 106 M-1 in CTAC, and (1.8 ± 0.9) × 106 M-1 in HSA. Fluorescence experiments confirm that aggregation of I drops as the concentration of surfactant is raised. Triplet quantum yields also decreased upon aggregation and were ΦT = 0.59, 0.16, and < 0.01 in SDS, CTAC, and HSA, respectively. These results indicate that the affinity of I for the environment is not just due to ionic interactions; hydrophobic interactions play an equally important role. Copyright © 2006 Society of Porphyrins & Phthalocyanines. 2006 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10884246_v10_n1_p33_Rodriguez http://hdl.handle.net/20.500.12110/paper_10884246_v10_n1_p33_Rodriguez
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Aggregation
Albumin
Hydrophobic interactions
Micelles
Tetrakis(1,1- dimethyl-2-trimethylammonium)ethylphthalocyaninato zinc(II) tetraiodide
spellingShingle Aggregation
Albumin
Hydrophobic interactions
Micelles
Tetrakis(1,1- dimethyl-2-trimethylammonium)ethylphthalocyaninato zinc(II) tetraiodide
Effect of aggregation of a cationic phthalocyanine in micelles and in the presence of human serum albumin
topic_facet Aggregation
Albumin
Hydrophobic interactions
Micelles
Tetrakis(1,1- dimethyl-2-trimethylammonium)ethylphthalocyaninato zinc(II) tetraiodide
description The photophysical properties of tetrakis(1,1-dimethyl-2-trimethylammonium) ethylphthalocyaninato zinc(II) tetraiodide (I) - a water-soluble cationic phthalocyanine - are presented in the presence of human serum albumin (HSA) and in micelles of sodium dodecylsulfate (SDS) and hexadecyltrimethylammonium chloride (CTAC). Spectrophotometric measurements showed that the surfactants SDS and CTAC induce monomerization of I, although the latter less efficiently than the former. This effect is less pronounced in the presence of HSA. The strength of this effect is evaluated through dimerization constants, which are K d = (5 ± 1) × 105 M-1 in SDS, (1.5 ± 0.5) × 106 M-1 in CTAC, and (1.8 ± 0.9) × 106 M-1 in HSA. Fluorescence experiments confirm that aggregation of I drops as the concentration of surfactant is raised. Triplet quantum yields also decreased upon aggregation and were ΦT = 0.59, 0.16, and < 0.01 in SDS, CTAC, and HSA, respectively. These results indicate that the affinity of I for the environment is not just due to ionic interactions; hydrophobic interactions play an equally important role. Copyright © 2006 Society of Porphyrins & Phthalocyanines.
title Effect of aggregation of a cationic phthalocyanine in micelles and in the presence of human serum albumin
title_short Effect of aggregation of a cationic phthalocyanine in micelles and in the presence of human serum albumin
title_full Effect of aggregation of a cationic phthalocyanine in micelles and in the presence of human serum albumin
title_fullStr Effect of aggregation of a cationic phthalocyanine in micelles and in the presence of human serum albumin
title_full_unstemmed Effect of aggregation of a cationic phthalocyanine in micelles and in the presence of human serum albumin
title_sort effect of aggregation of a cationic phthalocyanine in micelles and in the presence of human serum albumin
publishDate 2006
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10884246_v10_n1_p33_Rodriguez
http://hdl.handle.net/20.500.12110/paper_10884246_v10_n1_p33_Rodriguez
_version_ 1768543195145175040

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