Memory traces compete under regimes of limited Arc protein synthesis: Implications for memory interference

Recently encoded information can be lost in the presence of new information, a process called '. retrograde interference'. Retrograde interference has been extensively described for more than a century; however, little is known about its underlying mechanisms. Different approaches agree on...

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Detalles Bibliográficos
Autores principales:	Martínez, María Cecilia, Alen, Nadia, Moncada, Diego, Viola, Haydée Ana María
Publicado:	2012
Materias:	Arc (activity-regulated cytoskeletal-associated protein) Hippocampus Memory interference Rat activity regulated cytoskeleton associated protein antisense oligonucleotide amnesia animal experiment animal model article avoidance behavior controlled study exploratory behavior hippocampus learning long term memory male memory memory consolidation memory interference mental performance mental task nerve cell plasticity nonhuman open field behavior protein synthesis regulation rat Animals Avoidance Learning Cytoskeletal Proteins Exploratory Behavior Male Memory, Long-Term Nerve Tissue Proteins Oligonucleotides, Antisense Rats Rats, Wistar
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v98_n2_p165_Martinez http://hdl.handle.net/20.500.12110/paper_10747427_v98_n2_p165_Martinez
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_10747427_v98_n2_p165_Martinez
record_format	dspace
spelling	paper:paper_10747427_v98_n2_p165_Martinez2023-06-08T16:05:09Z Memory traces compete under regimes of limited Arc protein synthesis: Implications for memory interference Martínez, María Cecilia Alen, Nadia Moncada, Diego Viola, Haydée Ana María Arc (activity-regulated cytoskeletal-associated protein) Hippocampus Memory interference Rat activity regulated cytoskeleton associated protein antisense oligonucleotide amnesia animal experiment animal model article avoidance behavior controlled study exploratory behavior hippocampus learning long term memory male memory memory consolidation memory interference mental performance mental task nerve cell plasticity nonhuman open field behavior protein synthesis regulation rat Animals Avoidance Learning Cytoskeletal Proteins Exploratory Behavior Hippocampus Male Memory, Long-Term Nerve Tissue Proteins Oligonucleotides, Antisense Rats Rats, Wistar Recently encoded information can be lost in the presence of new information, a process called '. retrograde interference'. Retrograde interference has been extensively described for more than a century; however, little is known about its underlying mechanisms. Different approaches agree on the need of the synthesis of plasticity related proteins (PRPs) to consolidate a long-term memory (LTM). Our hypothesis is that when PRPs are limited, interference of a task over LTM formation of another may be due to the utilization of protein resources common to both tasks. Here, by combining the tasks of inhibitory avoidance (IA) and open field (OF) exploration in rats, we show that memory traces compete for their stabilization if PRPs are limited. As a result, LTM is formed for only one of the tasks with a consequent decrease in the memory for the other. Furthermore, infusing Arc antisense oligonucleotide into the dorsal hippocampus, we found that Arc is necessary for LTM formation of these two types of learning tasks and is one of the PRPs that can be shared between them when animals are trained in both OF and IA. In sum, these findings suggest that under conditions of reduced protein availability, a learning task interferes with LTM formation of another by using the available PRPs. © 2012 Elsevier Inc. Fil:Martínez, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Alen, N. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Moncada, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Viola, H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2012 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v98_n2_p165_Martinez http://hdl.handle.net/20.500.12110/paper_10747427_v98_n2_p165_Martinez
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Arc (activity-regulated cytoskeletal-associated protein) Hippocampus Memory interference Rat activity regulated cytoskeleton associated protein antisense oligonucleotide amnesia animal experiment animal model article avoidance behavior controlled study exploratory behavior hippocampus learning long term memory male memory memory consolidation memory interference mental performance mental task nerve cell plasticity nonhuman open field behavior protein synthesis regulation rat Animals Avoidance Learning Cytoskeletal Proteins Exploratory Behavior Hippocampus Male Memory, Long-Term Nerve Tissue Proteins Oligonucleotides, Antisense Rats Rats, Wistar
spellingShingle	Arc (activity-regulated cytoskeletal-associated protein) Hippocampus Memory interference Rat activity regulated cytoskeleton associated protein antisense oligonucleotide amnesia animal experiment animal model article avoidance behavior controlled study exploratory behavior hippocampus learning long term memory male memory memory consolidation memory interference mental performance mental task nerve cell plasticity nonhuman open field behavior protein synthesis regulation rat Animals Avoidance Learning Cytoskeletal Proteins Exploratory Behavior Hippocampus Male Memory, Long-Term Nerve Tissue Proteins Oligonucleotides, Antisense Rats Rats, Wistar Martínez, María Cecilia Alen, Nadia Moncada, Diego Viola, Haydée Ana María Memory traces compete under regimes of limited Arc protein synthesis: Implications for memory interference
topic_facet	Arc (activity-regulated cytoskeletal-associated protein) Hippocampus Memory interference Rat activity regulated cytoskeleton associated protein antisense oligonucleotide amnesia animal experiment animal model article avoidance behavior controlled study exploratory behavior hippocampus learning long term memory male memory memory consolidation memory interference mental performance mental task nerve cell plasticity nonhuman open field behavior protein synthesis regulation rat Animals Avoidance Learning Cytoskeletal Proteins Exploratory Behavior Hippocampus Male Memory, Long-Term Nerve Tissue Proteins Oligonucleotides, Antisense Rats Rats, Wistar
description	Recently encoded information can be lost in the presence of new information, a process called '. retrograde interference'. Retrograde interference has been extensively described for more than a century; however, little is known about its underlying mechanisms. Different approaches agree on the need of the synthesis of plasticity related proteins (PRPs) to consolidate a long-term memory (LTM). Our hypothesis is that when PRPs are limited, interference of a task over LTM formation of another may be due to the utilization of protein resources common to both tasks. Here, by combining the tasks of inhibitory avoidance (IA) and open field (OF) exploration in rats, we show that memory traces compete for their stabilization if PRPs are limited. As a result, LTM is formed for only one of the tasks with a consequent decrease in the memory for the other. Furthermore, infusing Arc antisense oligonucleotide into the dorsal hippocampus, we found that Arc is necessary for LTM formation of these two types of learning tasks and is one of the PRPs that can be shared between them when animals are trained in both OF and IA. In sum, these findings suggest that under conditions of reduced protein availability, a learning task interferes with LTM formation of another by using the available PRPs. © 2012 Elsevier Inc.
author	Martínez, María Cecilia Alen, Nadia Moncada, Diego Viola, Haydée Ana María
author_facet	Martínez, María Cecilia Alen, Nadia Moncada, Diego Viola, Haydée Ana María
author_sort	Martínez, María Cecilia
title	Memory traces compete under regimes of limited Arc protein synthesis: Implications for memory interference
title_short	Memory traces compete under regimes of limited Arc protein synthesis: Implications for memory interference
title_full	Memory traces compete under regimes of limited Arc protein synthesis: Implications for memory interference
title_fullStr	Memory traces compete under regimes of limited Arc protein synthesis: Implications for memory interference
title_full_unstemmed	Memory traces compete under regimes of limited Arc protein synthesis: Implications for memory interference
title_sort	memory traces compete under regimes of limited arc protein synthesis: implications for memory interference
publishDate	2012
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v98_n2_p165_Martinez http://hdl.handle.net/20.500.12110/paper_10747427_v98_n2_p165_Martinez
work_keys_str_mv	AT martinezmariacecilia memorytracescompeteunderregimesoflimitedarcproteinsynthesisimplicationsformemoryinterference AT alennadia memorytracescompeteunderregimesoflimitedarcproteinsynthesisimplicationsformemoryinterference AT moncadadiego memorytracescompeteunderregimesoflimitedarcproteinsynthesisimplicationsformemoryinterference AT violahaydeeanamaria memorytracescompeteunderregimesoflimitedarcproteinsynthesisimplicationsformemoryinterference
_version_	1768543287988191232

Memory traces compete under regimes of limited Arc protein synthesis: Implications for memory interference

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