Memory consolidation and expression of object recognition are susceptible to retroactive interference

With the aim of analyzing if object recognition long-term memory (OR-LTM) formation is susceptible to retroactive interference (RI), we submitted rats to sequential sample sessions using the same arena but changing the identity of a pair of objects placed in it. Separate groups of animals were teste...

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Autores principales:	Martínez, María Cecilia, Lopes da Cunha, Pamela J., Viola, Haydée Ana María
Publicado:	2017
Materias:	Dorsal hippocampus Long-term memory Medial prefrontal cortex Object recognition task Rat Retroactive interference animal experiment brain region dorsal hippocampus long term memory medial prefrontal cortex memory consolidation nonhuman recognition animal drug effects hippocampus male memory physiology prefrontal cortex rat Wistar rat 4 aminobutyric acid A receptor stimulating agent muscimol Animals GABA-A Receptor Agonists Hippocampus Male Memory Memory Consolidation Memory, Long-Term Muscimol Prefrontal Cortex Rats Rats, Wistar Recognition (Psychology)
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v138_n_p198_Villar http://hdl.handle.net/20.500.12110/paper_10747427_v138_n_p198_Villar
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_10747427_v138_n_p198_Villar
record_format	dspace
spelling	paper:paper_10747427_v138_n_p198_Villar2023-06-08T16:05:04Z Memory consolidation and expression of object recognition are susceptible to retroactive interference Martínez, María Cecilia Lopes da Cunha, Pamela J. Viola, Haydée Ana María Dorsal hippocampus Long-term memory Medial prefrontal cortex Object recognition task Rat Retroactive interference animal experiment brain region dorsal hippocampus long term memory medial prefrontal cortex memory consolidation nonhuman recognition animal drug effects hippocampus long term memory male memory memory consolidation physiology prefrontal cortex rat recognition Wistar rat 4 aminobutyric acid A receptor stimulating agent muscimol Animals GABA-A Receptor Agonists Hippocampus Male Memory Memory Consolidation Memory, Long-Term Muscimol Prefrontal Cortex Rats Rats, Wistar Recognition (Psychology) With the aim of analyzing if object recognition long-term memory (OR-LTM) formation is susceptible to retroactive interference (RI), we submitted rats to sequential sample sessions using the same arena but changing the identity of a pair of objects placed in it. Separate groups of animals were tested in the arena in order to evaluate the LTM for these objects. Our results suggest that OR-LTM formation was retroactively interfered within a critical time window by the exploration of a new, but not familiar, object. This RI acted on the consolidation of the object explored in the first sample session because its OR-STM measured 3 h after training was not affected, whereas the OR-LTM measured at 24 h was impaired. This sample session also impaired the expression of OR memory when it took place before the test. Moreover, local inactivation of the dorsal Hippocampus (Hp) or the medial Prefrontal Cortex (mPFC) previous to the exploration of the second pair of objects impaired their consolidation restoring the LTM for the objects explored in the first session. This data suggests that both brain regions are involved in the processing of OR-memory and also that if those regions are engaged in another process before finishing the first consolidation process its LTM will be impaired by RI. © 2016 Elsevier Inc. Fil:Martinez, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Lopes da Cunha, P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Viola, H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2017 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v138_n_p198_Villar http://hdl.handle.net/20.500.12110/paper_10747427_v138_n_p198_Villar
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Dorsal hippocampus Long-term memory Medial prefrontal cortex Object recognition task Rat Retroactive interference animal experiment brain region dorsal hippocampus long term memory medial prefrontal cortex memory consolidation nonhuman recognition animal drug effects hippocampus long term memory male memory memory consolidation physiology prefrontal cortex rat recognition Wistar rat 4 aminobutyric acid A receptor stimulating agent muscimol Animals GABA-A Receptor Agonists Hippocampus Male Memory Memory Consolidation Memory, Long-Term Muscimol Prefrontal Cortex Rats Rats, Wistar Recognition (Psychology)
spellingShingle	Dorsal hippocampus Long-term memory Medial prefrontal cortex Object recognition task Rat Retroactive interference animal experiment brain region dorsal hippocampus long term memory medial prefrontal cortex memory consolidation nonhuman recognition animal drug effects hippocampus long term memory male memory memory consolidation physiology prefrontal cortex rat recognition Wistar rat 4 aminobutyric acid A receptor stimulating agent muscimol Animals GABA-A Receptor Agonists Hippocampus Male Memory Memory Consolidation Memory, Long-Term Muscimol Prefrontal Cortex Rats Rats, Wistar Recognition (Psychology) Martínez, María Cecilia Lopes da Cunha, Pamela J. Viola, Haydée Ana María Memory consolidation and expression of object recognition are susceptible to retroactive interference
topic_facet	Dorsal hippocampus Long-term memory Medial prefrontal cortex Object recognition task Rat Retroactive interference animal experiment brain region dorsal hippocampus long term memory medial prefrontal cortex memory consolidation nonhuman recognition animal drug effects hippocampus long term memory male memory memory consolidation physiology prefrontal cortex rat recognition Wistar rat 4 aminobutyric acid A receptor stimulating agent muscimol Animals GABA-A Receptor Agonists Hippocampus Male Memory Memory Consolidation Memory, Long-Term Muscimol Prefrontal Cortex Rats Rats, Wistar Recognition (Psychology)
description	With the aim of analyzing if object recognition long-term memory (OR-LTM) formation is susceptible to retroactive interference (RI), we submitted rats to sequential sample sessions using the same arena but changing the identity of a pair of objects placed in it. Separate groups of animals were tested in the arena in order to evaluate the LTM for these objects. Our results suggest that OR-LTM formation was retroactively interfered within a critical time window by the exploration of a new, but not familiar, object. This RI acted on the consolidation of the object explored in the first sample session because its OR-STM measured 3 h after training was not affected, whereas the OR-LTM measured at 24 h was impaired. This sample session also impaired the expression of OR memory when it took place before the test. Moreover, local inactivation of the dorsal Hippocampus (Hp) or the medial Prefrontal Cortex (mPFC) previous to the exploration of the second pair of objects impaired their consolidation restoring the LTM for the objects explored in the first session. This data suggests that both brain regions are involved in the processing of OR-memory and also that if those regions are engaged in another process before finishing the first consolidation process its LTM will be impaired by RI. © 2016 Elsevier Inc.
author	Martínez, María Cecilia Lopes da Cunha, Pamela J. Viola, Haydée Ana María
author_facet	Martínez, María Cecilia Lopes da Cunha, Pamela J. Viola, Haydée Ana María
author_sort	Martínez, María Cecilia
title	Memory consolidation and expression of object recognition are susceptible to retroactive interference
title_short	Memory consolidation and expression of object recognition are susceptible to retroactive interference
title_full	Memory consolidation and expression of object recognition are susceptible to retroactive interference
title_fullStr	Memory consolidation and expression of object recognition are susceptible to retroactive interference
title_full_unstemmed	Memory consolidation and expression of object recognition are susceptible to retroactive interference
title_sort	memory consolidation and expression of object recognition are susceptible to retroactive interference
publishDate	2017
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v138_n_p198_Villar http://hdl.handle.net/20.500.12110/paper_10747427_v138_n_p198_Villar
work_keys_str_mv	AT martinezmariacecilia memoryconsolidationandexpressionofobjectrecognitionaresusceptibletoretroactiveinterference AT lopesdacunhapamelaj memoryconsolidationandexpressionofobjectrecognitionaresusceptibletoretroactiveinterference AT violahaydeeanamaria memoryconsolidationandexpressionofobjectrecognitionaresusceptibletoretroactiveinterference
_version_	1768545842641240064

Memory consolidation and expression of object recognition are susceptible to retroactive interference

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