Neural correlates of expression-independent memories in the crab Neohelice

The neural correlates of memory have been usually examined considering that memory retrieval and memory expression are interchangeable concepts. However, our studies in the crab Neohelice (Chasmagnathus) granulata and in other memory models have shown that memory expression is not necessary for memo...

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Autores principales:	Maza, Francisco Javier, Locatelli, Fernando Federico, Delorenzi, Alejandro
Publicado:	2016
Materias:	Calcium imaging Memory Memory expression Reconsolidation Retrieval calcium ion amino acid receptor blocking agent dizocilpine maleate muscarinic receptor blocking agent scopolamine bromide animal behavior animal cell animal experiment animal tissue Article behavior assessment brain brain function brain region cell activity cell function controlled study crab functional assessment in vivo study long term memory male medulla terminalis memory memory expression memory persistence molecular dynamics molecular imaging Neohelice nonhuman recall short term memory signal detection stimulus response animal Brachyura drug effects ganglion memory consolidation physiology Animals Behavior, Animal Dizocilpine Maleate Excitatory Amino Acid Antagonists Ganglia, Invertebrate Male Memory Consolidation Memory, Long-Term Mental Recall Muscarinic Antagonists Scopolamine Hydrobromide
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v131_n_p61_Maza http://hdl.handle.net/20.500.12110/paper_10747427_v131_n_p61_Maza
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_10747427_v131_n_p61_Maza
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spelling	paper:paper_10747427_v131_n_p61_Maza2023-06-08T16:05:03Z Neural correlates of expression-independent memories in the crab Neohelice Maza, Francisco Javier Locatelli, Fernando Federico Delorenzi, Alejandro Calcium imaging Memory Memory expression Reconsolidation Retrieval calcium ion amino acid receptor blocking agent dizocilpine maleate muscarinic receptor blocking agent scopolamine bromide animal behavior animal cell animal experiment animal tissue Article behavior assessment brain brain function brain region cell activity cell function controlled study crab functional assessment in vivo study long term memory male medulla terminalis memory memory expression memory persistence molecular dynamics molecular imaging Neohelice nonhuman recall short term memory signal detection stimulus response animal Brachyura drug effects ganglion memory memory consolidation physiology Animals Behavior, Animal Brachyura Dizocilpine Maleate Excitatory Amino Acid Antagonists Ganglia, Invertebrate Male Memory Memory Consolidation Memory, Long-Term Mental Recall Muscarinic Antagonists Scopolamine Hydrobromide The neural correlates of memory have been usually examined considering that memory retrieval and memory expression are interchangeable concepts. However, our studies in the crab Neohelice (Chasmagnathus) granulata and in other memory models have shown that memory expression is not necessary for memory to be re-activated and become labile. In order to examine putative neural correlates of memory in the crab Neohelice, we contrast changes induced by training in both animal's behavior and neuronal responses in the medulla terminalis using in vivo Ca2+ imaging. Disruption of long-term memory by the amnesic agents MK-801 or scopolamine (5 μg/g) blocks the learning-induced changes in the Ca2+ responses in the medulla terminalis. Conversely, treatments that lead to an unexpressed but persistent memory (weak training protocol or scopolamine 0.1 μg/g) do not block these learning-induced neural changes. The present results reveal a set of changes in the neural activity induced by training that correlates with memory persistence but not with the probability of this memory to be expressed in the long-term. In addition, the study constitutes the first in vivo evidence in favor of a role of the medulla terminalis in learning and memory in crustaceans, and provides a physiological evidence indicating that memory persistence and the probability of memory to be expressed might involve separate components of memory traces. © 2016 Elsevier Inc. Fil:Maza, F.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Locatelli, F.F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Delorenzi, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2016 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v131_n_p61_Maza http://hdl.handle.net/20.500.12110/paper_10747427_v131_n_p61_Maza
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Calcium imaging Memory Memory expression Reconsolidation Retrieval calcium ion amino acid receptor blocking agent dizocilpine maleate muscarinic receptor blocking agent scopolamine bromide animal behavior animal cell animal experiment animal tissue Article behavior assessment brain brain function brain region cell activity cell function controlled study crab functional assessment in vivo study long term memory male medulla terminalis memory memory expression memory persistence molecular dynamics molecular imaging Neohelice nonhuman recall short term memory signal detection stimulus response animal Brachyura drug effects ganglion memory memory consolidation physiology Animals Behavior, Animal Brachyura Dizocilpine Maleate Excitatory Amino Acid Antagonists Ganglia, Invertebrate Male Memory Memory Consolidation Memory, Long-Term Mental Recall Muscarinic Antagonists Scopolamine Hydrobromide
spellingShingle	Calcium imaging Memory Memory expression Reconsolidation Retrieval calcium ion amino acid receptor blocking agent dizocilpine maleate muscarinic receptor blocking agent scopolamine bromide animal behavior animal cell animal experiment animal tissue Article behavior assessment brain brain function brain region cell activity cell function controlled study crab functional assessment in vivo study long term memory male medulla terminalis memory memory expression memory persistence molecular dynamics molecular imaging Neohelice nonhuman recall short term memory signal detection stimulus response animal Brachyura drug effects ganglion memory memory consolidation physiology Animals Behavior, Animal Brachyura Dizocilpine Maleate Excitatory Amino Acid Antagonists Ganglia, Invertebrate Male Memory Memory Consolidation Memory, Long-Term Mental Recall Muscarinic Antagonists Scopolamine Hydrobromide Maza, Francisco Javier Locatelli, Fernando Federico Delorenzi, Alejandro Neural correlates of expression-independent memories in the crab Neohelice
topic_facet	Calcium imaging Memory Memory expression Reconsolidation Retrieval calcium ion amino acid receptor blocking agent dizocilpine maleate muscarinic receptor blocking agent scopolamine bromide animal behavior animal cell animal experiment animal tissue Article behavior assessment brain brain function brain region cell activity cell function controlled study crab functional assessment in vivo study long term memory male medulla terminalis memory memory expression memory persistence molecular dynamics molecular imaging Neohelice nonhuman recall short term memory signal detection stimulus response animal Brachyura drug effects ganglion memory memory consolidation physiology Animals Behavior, Animal Brachyura Dizocilpine Maleate Excitatory Amino Acid Antagonists Ganglia, Invertebrate Male Memory Memory Consolidation Memory, Long-Term Mental Recall Muscarinic Antagonists Scopolamine Hydrobromide
description	The neural correlates of memory have been usually examined considering that memory retrieval and memory expression are interchangeable concepts. However, our studies in the crab Neohelice (Chasmagnathus) granulata and in other memory models have shown that memory expression is not necessary for memory to be re-activated and become labile. In order to examine putative neural correlates of memory in the crab Neohelice, we contrast changes induced by training in both animal's behavior and neuronal responses in the medulla terminalis using in vivo Ca2+ imaging. Disruption of long-term memory by the amnesic agents MK-801 or scopolamine (5 μg/g) blocks the learning-induced changes in the Ca2+ responses in the medulla terminalis. Conversely, treatments that lead to an unexpressed but persistent memory (weak training protocol or scopolamine 0.1 μg/g) do not block these learning-induced neural changes. The present results reveal a set of changes in the neural activity induced by training that correlates with memory persistence but not with the probability of this memory to be expressed in the long-term. In addition, the study constitutes the first in vivo evidence in favor of a role of the medulla terminalis in learning and memory in crustaceans, and provides a physiological evidence indicating that memory persistence and the probability of memory to be expressed might involve separate components of memory traces. © 2016 Elsevier Inc.
author	Maza, Francisco Javier Locatelli, Fernando Federico Delorenzi, Alejandro
author_facet	Maza, Francisco Javier Locatelli, Fernando Federico Delorenzi, Alejandro
author_sort	Maza, Francisco Javier
title	Neural correlates of expression-independent memories in the crab Neohelice
title_short	Neural correlates of expression-independent memories in the crab Neohelice
title_full	Neural correlates of expression-independent memories in the crab Neohelice
title_fullStr	Neural correlates of expression-independent memories in the crab Neohelice
title_full_unstemmed	Neural correlates of expression-independent memories in the crab Neohelice
title_sort	neural correlates of expression-independent memories in the crab neohelice
publishDate	2016
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10747427_v131_n_p61_Maza http://hdl.handle.net/20.500.12110/paper_10747427_v131_n_p61_Maza
work_keys_str_mv	AT mazafranciscojavier neuralcorrelatesofexpressionindependentmemoriesinthecrabneohelice AT locatellifernandofederico neuralcorrelatesofexpressionindependentmemoriesinthecrabneohelice AT delorenzialejandro neuralcorrelatesofexpressionindependentmemoriesinthecrabneohelice
_version_	1768542469109055488

Neural correlates of expression-independent memories in the crab Neohelice

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