Surface expression of NMDA receptor changes during memory consolidation in the crab Neohelice granulata

The aim of the present study was to analyze the surface expression of the NMDA-like receptors during the consolidation of contextual learning in the crab Neohelice granulata. Memory storage is based on alterations in the strength of synaptic connections between neurons. The glutamatergic synapses un...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hepp, Yanil, Salles, Angeles, Carbó Tano, Martín, Pedreira, Maria Eugenia, Freudenthal, Ramiro Angel María
Publicado:	2016
Materias:	bicuculline n methyl dextro aspartic acid receptor 4 aminobutyric acid A receptor blocking agent adult animal experiment Article cell membrane cell migration controlled study crab down regulation long term memory male memory consolidation Neohelice granulata nerve cell plasticity nonhuman priority journal protein expression regulatory mechanism surface property thoracic ganglion upregulation animal association Brachyura brain drug effects learning metabolism physiology protein subunit Animals Bicuculline Brain Cues GABA-A Receptor Antagonists Learning Male Memory Consolidation Protein Subunits Receptors, N-Methyl-D-Aspartate
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10720502_v23_n8_p427_Hepp http://hdl.handle.net/20.500.12110/paper_10720502_v23_n8_p427_Hepp
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_10720502_v23_n8_p427_Hepp
record_format	dspace
spelling	paper:paper_10720502_v23_n8_p427_Hepp2023-06-08T16:04:49Z Surface expression of NMDA receptor changes during memory consolidation in the crab Neohelice granulata Hepp, Yanil Salles, Angeles Carbó Tano, Martín Pedreira, Maria Eugenia Freudenthal, Ramiro Angel María bicuculline n methyl dextro aspartic acid receptor 4 aminobutyric acid A receptor blocking agent bicuculline n methyl dextro aspartic acid receptor adult animal experiment Article cell membrane cell migration controlled study crab down regulation long term memory male memory consolidation Neohelice granulata nerve cell plasticity nonhuman priority journal protein expression regulatory mechanism surface property thoracic ganglion upregulation animal association Brachyura brain drug effects learning memory consolidation metabolism physiology protein subunit Animals Bicuculline Brachyura Brain Cues GABA-A Receptor Antagonists Learning Male Memory Consolidation Protein Subunits Receptors, N-Methyl-D-Aspartate The aim of the present study was to analyze the surface expression of the NMDA-like receptors during the consolidation of contextual learning in the crab Neohelice granulata. Memory storage is based on alterations in the strength of synaptic connections between neurons. The glutamatergic synapses undergo various forms of N-methyl-D aspartate receptor (NMDAR)-dependent changes in strength, a process that affects the abundance of other receptors at the synapse and underlies some forms of learning and memory. Here we propose a direct regulation of the NMDAR. Changes in NMDAR's functionality might be induced by the modification of the subunit's expression or cellular trafficking. This trafficking does not only include NMDAR's movement between synaptic and extra-synaptic localizations but also the cycling between intracellular compartments and the plasma membrane, a process called surface expression. Consolidation of contextual learning affects the surface expression of the receptor without affecting its general expression. The surface expression of the GluN1 subunit of the NMDAR is down-regulated immediately after training, up-regulated 3 h after training and returns to nave and control levels 24 h after training. The changes in NMDAR surface expression observed in the central brain are not seen in the thoracic ganglion. A similar increment in surface expression of GluN1 in the central brain is observed 3 h after administration of the competitive GABAA receptor antagonist, bicuculline. These consolidation changes are part of a plasticity event that first, during the down-regulation, stabilizes the trace and later, at 3-h post-training, changes the threshold for synapse activation. Fil:Hepp, Y. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Salles, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Carbo-Tano, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Pedreira, M.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Freudenthal, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2016 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10720502_v23_n8_p427_Hepp http://hdl.handle.net/20.500.12110/paper_10720502_v23_n8_p427_Hepp
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	bicuculline n methyl dextro aspartic acid receptor 4 aminobutyric acid A receptor blocking agent bicuculline n methyl dextro aspartic acid receptor adult animal experiment Article cell membrane cell migration controlled study crab down regulation long term memory male memory consolidation Neohelice granulata nerve cell plasticity nonhuman priority journal protein expression regulatory mechanism surface property thoracic ganglion upregulation animal association Brachyura brain drug effects learning memory consolidation metabolism physiology protein subunit Animals Bicuculline Brachyura Brain Cues GABA-A Receptor Antagonists Learning Male Memory Consolidation Protein Subunits Receptors, N-Methyl-D-Aspartate
spellingShingle	bicuculline n methyl dextro aspartic acid receptor 4 aminobutyric acid A receptor blocking agent bicuculline n methyl dextro aspartic acid receptor adult animal experiment Article cell membrane cell migration controlled study crab down regulation long term memory male memory consolidation Neohelice granulata nerve cell plasticity nonhuman priority journal protein expression regulatory mechanism surface property thoracic ganglion upregulation animal association Brachyura brain drug effects learning memory consolidation metabolism physiology protein subunit Animals Bicuculline Brachyura Brain Cues GABA-A Receptor Antagonists Learning Male Memory Consolidation Protein Subunits Receptors, N-Methyl-D-Aspartate Hepp, Yanil Salles, Angeles Carbó Tano, Martín Pedreira, Maria Eugenia Freudenthal, Ramiro Angel María Surface expression of NMDA receptor changes during memory consolidation in the crab Neohelice granulata
topic_facet	bicuculline n methyl dextro aspartic acid receptor 4 aminobutyric acid A receptor blocking agent bicuculline n methyl dextro aspartic acid receptor adult animal experiment Article cell membrane cell migration controlled study crab down regulation long term memory male memory consolidation Neohelice granulata nerve cell plasticity nonhuman priority journal protein expression regulatory mechanism surface property thoracic ganglion upregulation animal association Brachyura brain drug effects learning memory consolidation metabolism physiology protein subunit Animals Bicuculline Brachyura Brain Cues GABA-A Receptor Antagonists Learning Male Memory Consolidation Protein Subunits Receptors, N-Methyl-D-Aspartate
description	The aim of the present study was to analyze the surface expression of the NMDA-like receptors during the consolidation of contextual learning in the crab Neohelice granulata. Memory storage is based on alterations in the strength of synaptic connections between neurons. The glutamatergic synapses undergo various forms of N-methyl-D aspartate receptor (NMDAR)-dependent changes in strength, a process that affects the abundance of other receptors at the synapse and underlies some forms of learning and memory. Here we propose a direct regulation of the NMDAR. Changes in NMDAR's functionality might be induced by the modification of the subunit's expression or cellular trafficking. This trafficking does not only include NMDAR's movement between synaptic and extra-synaptic localizations but also the cycling between intracellular compartments and the plasma membrane, a process called surface expression. Consolidation of contextual learning affects the surface expression of the receptor without affecting its general expression. The surface expression of the GluN1 subunit of the NMDAR is down-regulated immediately after training, up-regulated 3 h after training and returns to nave and control levels 24 h after training. The changes in NMDAR surface expression observed in the central brain are not seen in the thoracic ganglion. A similar increment in surface expression of GluN1 in the central brain is observed 3 h after administration of the competitive GABAA receptor antagonist, bicuculline. These consolidation changes are part of a plasticity event that first, during the down-regulation, stabilizes the trace and later, at 3-h post-training, changes the threshold for synapse activation.
author	Hepp, Yanil Salles, Angeles Carbó Tano, Martín Pedreira, Maria Eugenia Freudenthal, Ramiro Angel María
author_facet	Hepp, Yanil Salles, Angeles Carbó Tano, Martín Pedreira, Maria Eugenia Freudenthal, Ramiro Angel María
author_sort	Hepp, Yanil
title	Surface expression of NMDA receptor changes during memory consolidation in the crab Neohelice granulata
title_short	Surface expression of NMDA receptor changes during memory consolidation in the crab Neohelice granulata
title_full	Surface expression of NMDA receptor changes during memory consolidation in the crab Neohelice granulata
title_fullStr	Surface expression of NMDA receptor changes during memory consolidation in the crab Neohelice granulata
title_full_unstemmed	Surface expression of NMDA receptor changes during memory consolidation in the crab Neohelice granulata
title_sort	surface expression of nmda receptor changes during memory consolidation in the crab neohelice granulata
publishDate	2016
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10720502_v23_n8_p427_Hepp http://hdl.handle.net/20.500.12110/paper_10720502_v23_n8_p427_Hepp
work_keys_str_mv	AT heppyanil surfaceexpressionofnmdareceptorchangesduringmemoryconsolidationinthecrabneohelicegranulata AT sallesangeles surfaceexpressionofnmdareceptorchangesduringmemoryconsolidationinthecrabneohelicegranulata AT carbotanomartin surfaceexpressionofnmdareceptorchangesduringmemoryconsolidationinthecrabneohelicegranulata AT pedreiramariaeugenia surfaceexpressionofnmdareceptorchangesduringmemoryconsolidationinthecrabneohelicegranulata AT freudenthalramiroangelmaria surfaceexpressionofnmdareceptorchangesduringmemoryconsolidationinthecrabneohelicegranulata
_version_	1768545474663415808

Surface expression of NMDA receptor changes during memory consolidation in the crab Neohelice granulata

Ejemplares similares