PKMζ inactivation induces spatial familiarity
Spatial familiarization consists of a decrease in the exploratory activity over time after exposure to a place. Here, we show that a 30-min exposure to an open field led to a pronounced decrease in the exploratory behavior of rats, generating context familiarity. This behavioral output is associated...
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2008
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10720502_v15_n11_p810_Moncada http://hdl.handle.net/20.500.12110/paper_10720502_v15_n11_p810_Moncada |
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paper:paper_10720502_v15_n11_p810_Moncada2023-06-08T16:04:48Z PKMζ inactivation induces spatial familiarity Moncada, Diego Viola, Haydée Ana María protein inhibitor protein kinase protein kinase m zeta unclassified drug zeta interacting protein enzyme inhibitor peptide protein kinase C protein kinase M zeta, rat animal experiment animal tissue article controlled study exploratory behavior hippocampus histology immunoblotting male nonhuman open field test priority journal rat spatial discrimination analysis of variance animal behavior drug effect exploratory behavior gene expression regulation hippocampus metabolism physiology recognition time Wistar rat Analysis of Variance Animals Enzyme Inhibitors Exploratory Behavior Gene Expression Regulation Hippocampus Male Peptides Protein Kinase C Rats Rats, Wistar Recognition (Psychology) Spatial Behavior Time Factors Spatial familiarization consists of a decrease in the exploratory activity over time after exposure to a place. Here, we show that a 30-min exposure to an open field led to a pronounced decrease in the exploratory behavior of rats, generating context familiarity. This behavioral output is associated with a selective decrease in hippocampal PKMζ levels. A short 5-min exposure did not induce spatial familiarity or a decrease in PKMζ, while inactivation of hippocampal PKMζ by the specific inhibitor ZIP was sufficient to induce spatial familiarity, suggesting that the decrease in PKMζ is involved in setting a given context as a familiar place. © 2008 Cold Spring Harbor Laboratory Press. Fil:Moncada, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Viola, H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2008 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10720502_v15_n11_p810_Moncada http://hdl.handle.net/20.500.12110/paper_10720502_v15_n11_p810_Moncada |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
protein inhibitor protein kinase protein kinase m zeta unclassified drug zeta interacting protein enzyme inhibitor peptide protein kinase C protein kinase M zeta, rat animal experiment animal tissue article controlled study exploratory behavior hippocampus histology immunoblotting male nonhuman open field test priority journal rat spatial discrimination analysis of variance animal behavior drug effect exploratory behavior gene expression regulation hippocampus metabolism physiology recognition time Wistar rat Analysis of Variance Animals Enzyme Inhibitors Exploratory Behavior Gene Expression Regulation Hippocampus Male Peptides Protein Kinase C Rats Rats, Wistar Recognition (Psychology) Spatial Behavior Time Factors |
| spellingShingle |
protein inhibitor protein kinase protein kinase m zeta unclassified drug zeta interacting protein enzyme inhibitor peptide protein kinase C protein kinase M zeta, rat animal experiment animal tissue article controlled study exploratory behavior hippocampus histology immunoblotting male nonhuman open field test priority journal rat spatial discrimination analysis of variance animal behavior drug effect exploratory behavior gene expression regulation hippocampus metabolism physiology recognition time Wistar rat Analysis of Variance Animals Enzyme Inhibitors Exploratory Behavior Gene Expression Regulation Hippocampus Male Peptides Protein Kinase C Rats Rats, Wistar Recognition (Psychology) Spatial Behavior Time Factors Moncada, Diego Viola, Haydée Ana María PKMζ inactivation induces spatial familiarity |
| topic_facet |
protein inhibitor protein kinase protein kinase m zeta unclassified drug zeta interacting protein enzyme inhibitor peptide protein kinase C protein kinase M zeta, rat animal experiment animal tissue article controlled study exploratory behavior hippocampus histology immunoblotting male nonhuman open field test priority journal rat spatial discrimination analysis of variance animal behavior drug effect exploratory behavior gene expression regulation hippocampus metabolism physiology recognition time Wistar rat Analysis of Variance Animals Enzyme Inhibitors Exploratory Behavior Gene Expression Regulation Hippocampus Male Peptides Protein Kinase C Rats Rats, Wistar Recognition (Psychology) Spatial Behavior Time Factors |
| description |
Spatial familiarization consists of a decrease in the exploratory activity over time after exposure to a place. Here, we show that a 30-min exposure to an open field led to a pronounced decrease in the exploratory behavior of rats, generating context familiarity. This behavioral output is associated with a selective decrease in hippocampal PKMζ levels. A short 5-min exposure did not induce spatial familiarity or a decrease in PKMζ, while inactivation of hippocampal PKMζ by the specific inhibitor ZIP was sufficient to induce spatial familiarity, suggesting that the decrease in PKMζ is involved in setting a given context as a familiar place. © 2008 Cold Spring Harbor Laboratory Press. |
| author |
Moncada, Diego Viola, Haydée Ana María |
| author_facet |
Moncada, Diego Viola, Haydée Ana María |
| author_sort |
Moncada, Diego |
| title |
PKMζ inactivation induces spatial familiarity |
| title_short |
PKMζ inactivation induces spatial familiarity |
| title_full |
PKMζ inactivation induces spatial familiarity |
| title_fullStr |
PKMζ inactivation induces spatial familiarity |
| title_full_unstemmed |
PKMζ inactivation induces spatial familiarity |
| title_sort |
pkmζ inactivation induces spatial familiarity |
| publishDate |
2008 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10720502_v15_n11_p810_Moncada http://hdl.handle.net/20.500.12110/paper_10720502_v15_n11_p810_Moncada |
| work_keys_str_mv |
AT moncadadiego pkmzinactivationinducesspatialfamiliarity AT violahaydeeanamaria pkmzinactivationinducesspatialfamiliarity |
| _version_ |
1768544003639214080 |