Correlation between gel structural properties and drug release pattern in scleroglucan matrices
The drug delivery behavior of scleroglucan hydrogels was correlated with the structural features found by means of steady-state fluorescence studies. Theophylline at 0.4 % in weight was used as the model drug and its release was measured using a Franz cell device. The results were fitted with a semi...
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2003
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10717544_v10_n2_p79_Daraio http://hdl.handle.net/20.500.12110/paper_10717544_v10_n2_p79_Daraio |
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paper:paper_10717544_v10_n2_p79_Daraio2023-06-08T16:04:46Z Correlation between gel structural properties and drug release pattern in scleroglucan matrices Daraio, Marta Edit Bernik, Delia Leticia Drug Release Fluorescent Molecular Probes Hydrophilic Matrices Scleroglucan scleroglucan theophylline analytic method article chemical model correlation analysis drug delivery system drug release empiricism fluorescence analysis hydrogel kinetics mathematical analysis microenvironment molecular probe priority journal steady state The drug delivery behavior of scleroglucan hydrogels was correlated with the structural features found by means of steady-state fluorescence studies. Theophylline at 0.4 % in weight was used as the model drug and its release was measured using a Franz cell device. The results were fitted with a semi-empirical power law equation, finding significant differences between the 0.5% and higher than 0.8% scleroglucan concentrations (w/w). Four molecular fluorescent probes were used to test microenvironmental properties of the gel cavities, which will play a key role on the release of the pharmaceutical drugs. The results found by the fluorescence analysis are in good agreement with the ones obtained by release kinetics. Fil:Daraio, M.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Bernik, D.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2003 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10717544_v10_n2_p79_Daraio http://hdl.handle.net/20.500.12110/paper_10717544_v10_n2_p79_Daraio |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Drug Release Fluorescent Molecular Probes Hydrophilic Matrices Scleroglucan scleroglucan theophylline analytic method article chemical model correlation analysis drug delivery system drug release empiricism fluorescence analysis hydrogel kinetics mathematical analysis microenvironment molecular probe priority journal steady state |
| spellingShingle |
Drug Release Fluorescent Molecular Probes Hydrophilic Matrices Scleroglucan scleroglucan theophylline analytic method article chemical model correlation analysis drug delivery system drug release empiricism fluorescence analysis hydrogel kinetics mathematical analysis microenvironment molecular probe priority journal steady state Daraio, Marta Edit Bernik, Delia Leticia Correlation between gel structural properties and drug release pattern in scleroglucan matrices |
| topic_facet |
Drug Release Fluorescent Molecular Probes Hydrophilic Matrices Scleroglucan scleroglucan theophylline analytic method article chemical model correlation analysis drug delivery system drug release empiricism fluorescence analysis hydrogel kinetics mathematical analysis microenvironment molecular probe priority journal steady state |
| description |
The drug delivery behavior of scleroglucan hydrogels was correlated with the structural features found by means of steady-state fluorescence studies. Theophylline at 0.4 % in weight was used as the model drug and its release was measured using a Franz cell device. The results were fitted with a semi-empirical power law equation, finding significant differences between the 0.5% and higher than 0.8% scleroglucan concentrations (w/w). Four molecular fluorescent probes were used to test microenvironmental properties of the gel cavities, which will play a key role on the release of the pharmaceutical drugs. The results found by the fluorescence analysis are in good agreement with the ones obtained by release kinetics. |
| author |
Daraio, Marta Edit Bernik, Delia Leticia |
| author_facet |
Daraio, Marta Edit Bernik, Delia Leticia |
| author_sort |
Daraio, Marta Edit |
| title |
Correlation between gel structural properties and drug release pattern in scleroglucan matrices |
| title_short |
Correlation between gel structural properties and drug release pattern in scleroglucan matrices |
| title_full |
Correlation between gel structural properties and drug release pattern in scleroglucan matrices |
| title_fullStr |
Correlation between gel structural properties and drug release pattern in scleroglucan matrices |
| title_full_unstemmed |
Correlation between gel structural properties and drug release pattern in scleroglucan matrices |
| title_sort |
correlation between gel structural properties and drug release pattern in scleroglucan matrices |
| publishDate |
2003 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10717544_v10_n2_p79_Daraio http://hdl.handle.net/20.500.12110/paper_10717544_v10_n2_p79_Daraio |
| work_keys_str_mv |
AT daraiomartaedit correlationbetweengelstructuralpropertiesanddrugreleasepatterninscleroglucanmatrices AT bernikdelialeticia correlationbetweengelstructuralpropertiesanddrugreleasepatterninscleroglucanmatrices |
| _version_ |
1768544461653016576 |