Retroactive interference of object-in-context long-term memory: Role of dorsal hippocampus and medial prefrontal cortex
Retroactive interference (RI) is a type of amnesia in which a new learning experience can impair the expression of a previous one. It has been studied in several types of memories for over a century. Here, we aimed to study in the long-term memory (LTM) formation of an object-in-context task, define...
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paper:paper_10509631_v24_n12_p1482_Martinez2023-06-08T16:02:55Z Retroactive interference of object-in-context long-term memory: Role of dorsal hippocampus and medial prefrontal cortex Martínez, María Cecilia Viola, Haydée Ana María Amnesia Episodic-like memory Learning and memory Muscimol Rat muscimol 4 aminobutyric acid A receptor stimulating agent muscimol adult amnesia animal experiment Article brain region controlled study exploratory behavior habituation hippocampal CA1 region learning long term memory male memory consolidation nonhuman prefrontal cortex priority journal rat retroactive interference short term memory animal drug effects hippocampus indwelling catheter long term memory neuropsychological test physiology prefrontal cortex recognition Wistar rat Animals Catheters, Indwelling GABA-A Receptor Agonists Hippocampus Male Memory, Long-Term Muscimol Neuropsychological Tests Prefrontal Cortex Rats, Wistar Recognition (Psychology) Retroactive interference (RI) is a type of amnesia in which a new learning experience can impair the expression of a previous one. It has been studied in several types of memories for over a century. Here, we aimed to study in the long-term memory (LTM) formation of an object-in-context task, defined as the recognition of a familiar object in a context different to that in which it was previously encountered. We trained rats with two sample trials, each taking place in a different context in association with different objects. Test sessions were performed 24 h later, to evaluate LTM for both object-context pairs using separate groups of trained rats. Furthermore, given the involvement of hippocampus (Hp) and medial prefrontal cortex (mPFC) in several recognition memories, we also analyzed the participation of these structures in the LTM formation of this task by the local infusion of muscimol. Our results show that object-in-context LTM formation is sensitive to RI by a different either familiar or novel object-context pair trial, experienced 1 h later. This interference occurs in a restricted temporal window and works on the LTM consolidation phase, leaving intact short-term memory expression. The second sample trial did not affect the object recognition part of the memory. Besides, muscimol treatment before the second sample trial blocks its object-in-context LTM and restores the first sample trial memory. We hypothesized that LTM-RI amnesia is probably caused by resources or cellular machinery competition in these brain regions when they are engaged in memory formation of the traces. In sum, when two different object-in-context memory traces are being processed, the second trace interferes with the consolidation of the first one requiring mPFC and CA1 dorsal Hp activation. © 2014 Wiley Periodicals, Inc. Fil:Martínez, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Viola, H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2014 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10509631_v24_n12_p1482_Martinez http://hdl.handle.net/20.500.12110/paper_10509631_v24_n12_p1482_Martinez |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Amnesia Episodic-like memory Learning and memory Muscimol Rat muscimol 4 aminobutyric acid A receptor stimulating agent muscimol adult amnesia animal experiment Article brain region controlled study exploratory behavior habituation hippocampal CA1 region learning long term memory male memory consolidation nonhuman prefrontal cortex priority journal rat retroactive interference short term memory animal drug effects hippocampus indwelling catheter long term memory neuropsychological test physiology prefrontal cortex recognition Wistar rat Animals Catheters, Indwelling GABA-A Receptor Agonists Hippocampus Male Memory, Long-Term Muscimol Neuropsychological Tests Prefrontal Cortex Rats, Wistar Recognition (Psychology) |
| spellingShingle |
Amnesia Episodic-like memory Learning and memory Muscimol Rat muscimol 4 aminobutyric acid A receptor stimulating agent muscimol adult amnesia animal experiment Article brain region controlled study exploratory behavior habituation hippocampal CA1 region learning long term memory male memory consolidation nonhuman prefrontal cortex priority journal rat retroactive interference short term memory animal drug effects hippocampus indwelling catheter long term memory neuropsychological test physiology prefrontal cortex recognition Wistar rat Animals Catheters, Indwelling GABA-A Receptor Agonists Hippocampus Male Memory, Long-Term Muscimol Neuropsychological Tests Prefrontal Cortex Rats, Wistar Recognition (Psychology) Martínez, María Cecilia Viola, Haydée Ana María Retroactive interference of object-in-context long-term memory: Role of dorsal hippocampus and medial prefrontal cortex |
| topic_facet |
Amnesia Episodic-like memory Learning and memory Muscimol Rat muscimol 4 aminobutyric acid A receptor stimulating agent muscimol adult amnesia animal experiment Article brain region controlled study exploratory behavior habituation hippocampal CA1 region learning long term memory male memory consolidation nonhuman prefrontal cortex priority journal rat retroactive interference short term memory animal drug effects hippocampus indwelling catheter long term memory neuropsychological test physiology prefrontal cortex recognition Wistar rat Animals Catheters, Indwelling GABA-A Receptor Agonists Hippocampus Male Memory, Long-Term Muscimol Neuropsychological Tests Prefrontal Cortex Rats, Wistar Recognition (Psychology) |
| description |
Retroactive interference (RI) is a type of amnesia in which a new learning experience can impair the expression of a previous one. It has been studied in several types of memories for over a century. Here, we aimed to study in the long-term memory (LTM) formation of an object-in-context task, defined as the recognition of a familiar object in a context different to that in which it was previously encountered. We trained rats with two sample trials, each taking place in a different context in association with different objects. Test sessions were performed 24 h later, to evaluate LTM for both object-context pairs using separate groups of trained rats. Furthermore, given the involvement of hippocampus (Hp) and medial prefrontal cortex (mPFC) in several recognition memories, we also analyzed the participation of these structures in the LTM formation of this task by the local infusion of muscimol. Our results show that object-in-context LTM formation is sensitive to RI by a different either familiar or novel object-context pair trial, experienced 1 h later. This interference occurs in a restricted temporal window and works on the LTM consolidation phase, leaving intact short-term memory expression. The second sample trial did not affect the object recognition part of the memory. Besides, muscimol treatment before the second sample trial blocks its object-in-context LTM and restores the first sample trial memory. We hypothesized that LTM-RI amnesia is probably caused by resources or cellular machinery competition in these brain regions when they are engaged in memory formation of the traces. In sum, when two different object-in-context memory traces are being processed, the second trace interferes with the consolidation of the first one requiring mPFC and CA1 dorsal Hp activation. © 2014 Wiley Periodicals, Inc. |
| author |
Martínez, María Cecilia Viola, Haydée Ana María |
| author_facet |
Martínez, María Cecilia Viola, Haydée Ana María |
| author_sort |
Martínez, María Cecilia |
| title |
Retroactive interference of object-in-context long-term memory: Role of dorsal hippocampus and medial prefrontal cortex |
| title_short |
Retroactive interference of object-in-context long-term memory: Role of dorsal hippocampus and medial prefrontal cortex |
| title_full |
Retroactive interference of object-in-context long-term memory: Role of dorsal hippocampus and medial prefrontal cortex |
| title_fullStr |
Retroactive interference of object-in-context long-term memory: Role of dorsal hippocampus and medial prefrontal cortex |
| title_full_unstemmed |
Retroactive interference of object-in-context long-term memory: Role of dorsal hippocampus and medial prefrontal cortex |
| title_sort |
retroactive interference of object-in-context long-term memory: role of dorsal hippocampus and medial prefrontal cortex |
| publishDate |
2014 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10509631_v24_n12_p1482_Martinez http://hdl.handle.net/20.500.12110/paper_10509631_v24_n12_p1482_Martinez |
| work_keys_str_mv |
AT martinezmariacecilia retroactiveinterferenceofobjectincontextlongtermmemoryroleofdorsalhippocampusandmedialprefrontalcortex AT violahaydeeanamaria retroactiveinterferenceofobjectincontextlongtermmemoryroleofdorsalhippocampusandmedialprefrontalcortex |
| _version_ |
1768546312539602944 |