Differentiation of isomeric hydroxypyridine N-Oxides using metal complexation and electrospray ionization mass spectrometry
Differentiation between two isomers of hydroxypyridine N-oxide according to the metal cation adducts generated by electrospray ionization (ESI) was investigated for different metal cations, namely Mg (II), Al (III), Ca (II), Sc (III), Fe (III), Co (II), Ni (II), Cu (II), Zn (II), Ga (III), besides t...
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2011
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10440305_v22_n3_p545_Butler http://hdl.handle.net/20.500.12110/paper_10440305_v22_n3_p545_Butler |
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paper:paper_10440305_v22_n3_p545_Butler2023-06-08T16:01:05Z Differentiation of isomeric hydroxypyridine N-Oxides using metal complexation and electrospray ionization mass spectrometry Electrospray Hydroxypyridine N-oxides Metal complexation Charged cations Charged complexes Complex formations Divalent cation Electrospray ionization mass spectrometry Electrosprays Gain insight Gasphase Hydroxypyridine Mass spectra Metal cation Metal complexation N-Oxides Neutral complexes Protonated molecules Quantum chemical calculations Relative stabilities Trivalent ion Calcium Cobalt compounds Electrospray ionization Gases Ionization of gases Iron compounds Isomers Ligands Mass spectrometers Mass spectrometry Metal ions Metals Positive ions Protonation Quantum chemistry Scandium Scandium compounds Zinc compounds Copper 2 hydroxypyridine oxide 3 hydroxypyridine oxide aluminum chloride calcium chloride cobalt chloride copper sulfate divalent cation ferrous chloride gallium chloride magnesium chloride nickel sulfate pyridine derivative scandium unclassified drug zinc chloride article chemical structure complex formation controlled study density functional theory electrospray mass spectrometry proton transport quantum chemistry Differentiation between two isomers of hydroxypyridine N-oxide according to the metal cation adducts generated by electrospray ionization (ESI) was investigated for different metal cations, namely Mg (II), Al (III), Ca (II), Sc (III), Fe (III), Co (II), Ni (II), Cu (II), Zn (II), Ga (III), besides the diatomic cation VO(IV). Protonated molecules of the isomeric hydroxypyridine N-oxides as well as the singly/doubly charged adducts formed from neutral or deprotonated ligands and a doubly/ triply charged cation were produced in the gas phase using ESI, recording mass spectra with different metal ions for each isomer. While complex formation was successful for 2- hydroxypyridine N-oxide with trivalent ions, in the case of 3-hydroxypyridine N-oxide, only peaks related to the protonated molecule were present. On the other hand, divalent cations formed specific species for each isomer, giving characteristic spectra in every case. Hence, differentiation was possible irrespective of the metal cation utilized. In addition, quantum chemical calculations at the B3LYP/6-31+G(d,p) level of theory were performed in order to gain insight into the different complexation of calcium(II) with the isomers of hydroxypyridine N-oxide. The relative stability in the gas phase of the neutral complexes of calcium made up of two ligands, as well as the singly charged and doubly charged complexes, was investigated. The results of these calculations improved the understanding of the differences observed in the mass spectra obtained for each isomer. © American Society for Mass Spectrometry,2011. 2011 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10440305_v22_n3_p545_Butler http://hdl.handle.net/20.500.12110/paper_10440305_v22_n3_p545_Butler |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Electrospray Hydroxypyridine N-oxides Metal complexation Charged cations Charged complexes Complex formations Divalent cation Electrospray ionization mass spectrometry Electrosprays Gain insight Gasphase Hydroxypyridine Mass spectra Metal cation Metal complexation N-Oxides Neutral complexes Protonated molecules Quantum chemical calculations Relative stabilities Trivalent ion Calcium Cobalt compounds Electrospray ionization Gases Ionization of gases Iron compounds Isomers Ligands Mass spectrometers Mass spectrometry Metal ions Metals Positive ions Protonation Quantum chemistry Scandium Scandium compounds Zinc compounds Copper 2 hydroxypyridine oxide 3 hydroxypyridine oxide aluminum chloride calcium chloride cobalt chloride copper sulfate divalent cation ferrous chloride gallium chloride magnesium chloride nickel sulfate pyridine derivative scandium unclassified drug zinc chloride article chemical structure complex formation controlled study density functional theory electrospray mass spectrometry proton transport quantum chemistry |
| spellingShingle |
Electrospray Hydroxypyridine N-oxides Metal complexation Charged cations Charged complexes Complex formations Divalent cation Electrospray ionization mass spectrometry Electrosprays Gain insight Gasphase Hydroxypyridine Mass spectra Metal cation Metal complexation N-Oxides Neutral complexes Protonated molecules Quantum chemical calculations Relative stabilities Trivalent ion Calcium Cobalt compounds Electrospray ionization Gases Ionization of gases Iron compounds Isomers Ligands Mass spectrometers Mass spectrometry Metal ions Metals Positive ions Protonation Quantum chemistry Scandium Scandium compounds Zinc compounds Copper 2 hydroxypyridine oxide 3 hydroxypyridine oxide aluminum chloride calcium chloride cobalt chloride copper sulfate divalent cation ferrous chloride gallium chloride magnesium chloride nickel sulfate pyridine derivative scandium unclassified drug zinc chloride article chemical structure complex formation controlled study density functional theory electrospray mass spectrometry proton transport quantum chemistry Differentiation of isomeric hydroxypyridine N-Oxides using metal complexation and electrospray ionization mass spectrometry |
| topic_facet |
Electrospray Hydroxypyridine N-oxides Metal complexation Charged cations Charged complexes Complex formations Divalent cation Electrospray ionization mass spectrometry Electrosprays Gain insight Gasphase Hydroxypyridine Mass spectra Metal cation Metal complexation N-Oxides Neutral complexes Protonated molecules Quantum chemical calculations Relative stabilities Trivalent ion Calcium Cobalt compounds Electrospray ionization Gases Ionization of gases Iron compounds Isomers Ligands Mass spectrometers Mass spectrometry Metal ions Metals Positive ions Protonation Quantum chemistry Scandium Scandium compounds Zinc compounds Copper 2 hydroxypyridine oxide 3 hydroxypyridine oxide aluminum chloride calcium chloride cobalt chloride copper sulfate divalent cation ferrous chloride gallium chloride magnesium chloride nickel sulfate pyridine derivative scandium unclassified drug zinc chloride article chemical structure complex formation controlled study density functional theory electrospray mass spectrometry proton transport quantum chemistry |
| description |
Differentiation between two isomers of hydroxypyridine N-oxide according to the metal cation adducts generated by electrospray ionization (ESI) was investigated for different metal cations, namely Mg (II), Al (III), Ca (II), Sc (III), Fe (III), Co (II), Ni (II), Cu (II), Zn (II), Ga (III), besides the diatomic cation VO(IV). Protonated molecules of the isomeric hydroxypyridine N-oxides as well as the singly/doubly charged adducts formed from neutral or deprotonated ligands and a doubly/ triply charged cation were produced in the gas phase using ESI, recording mass spectra with different metal ions for each isomer. While complex formation was successful for 2- hydroxypyridine N-oxide with trivalent ions, in the case of 3-hydroxypyridine N-oxide, only peaks related to the protonated molecule were present. On the other hand, divalent cations formed specific species for each isomer, giving characteristic spectra in every case. Hence, differentiation was possible irrespective of the metal cation utilized. In addition, quantum chemical calculations at the B3LYP/6-31+G(d,p) level of theory were performed in order to gain insight into the different complexation of calcium(II) with the isomers of hydroxypyridine N-oxide. The relative stability in the gas phase of the neutral complexes of calcium made up of two ligands, as well as the singly charged and doubly charged complexes, was investigated. The results of these calculations improved the understanding of the differences observed in the mass spectra obtained for each isomer. © American Society for Mass Spectrometry,2011. |
| title |
Differentiation of isomeric hydroxypyridine N-Oxides using metal complexation and electrospray ionization mass spectrometry |
| title_short |
Differentiation of isomeric hydroxypyridine N-Oxides using metal complexation and electrospray ionization mass spectrometry |
| title_full |
Differentiation of isomeric hydroxypyridine N-Oxides using metal complexation and electrospray ionization mass spectrometry |
| title_fullStr |
Differentiation of isomeric hydroxypyridine N-Oxides using metal complexation and electrospray ionization mass spectrometry |
| title_full_unstemmed |
Differentiation of isomeric hydroxypyridine N-Oxides using metal complexation and electrospray ionization mass spectrometry |
| title_sort |
differentiation of isomeric hydroxypyridine n-oxides using metal complexation and electrospray ionization mass spectrometry |
| publishDate |
2011 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10440305_v22_n3_p545_Butler http://hdl.handle.net/20.500.12110/paper_10440305_v22_n3_p545_Butler |
| _version_ |
1768543383140171776 |