Glyco-nano-oncology: Novel therapeutic opportunities by combining small and sweet
Recent efforts toward defining the molecular features of the tumor microenvironment have revealed dramatic changes in the expression of glycan-related genes including glycosyltransferases and glycosidases. These changes affect glycosylation of proteins and lipids not only in cancer cells themselves,...
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2016
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10436618_v109_n_p45_Hockl http://hdl.handle.net/20.500.12110/paper_10436618_v109_n_p45_Hockl |
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paper:paper_10436618_v109_n_p45_Hockl2023-06-08T16:01:02Z Glyco-nano-oncology: Novel therapeutic opportunities by combining small and sweet Bordoni, Andrea Verónica Croci Russo, Diego Omar Soler Illia, Galo Juan de Avila Arturo Cancer Drug delivery Galectins Glycobiology Nanotechnology Theranostics cancer vaccine dendrimer galectin galectin 1 glycan glycosphingolipid lectin liposome mucin nanocarrier nanoparticle proteoglycan sialic acid binding immunoglobulin like lectin Tn antigen vasculotropin nanoparticle cancer diagnosis cancer immunotherapy cancer prognosis cancer resistance cell surface glycobiology glycosylation human immune evasion metastasis molecular recognition molecularly targeted therapy nanotechnology nonhuman oncology priority journal Review sialylation theranostic nanomedicine tumor growth tumor microenvironment tumor vascularization animal metabolism nanotechnology Neoplasms Animals Glycosylation Humans Nanoparticles Nanotechnology Neoplasms Tumor Microenvironment Recent efforts toward defining the molecular features of the tumor microenvironment have revealed dramatic changes in the expression of glycan-related genes including glycosyltransferases and glycosidases. These changes affect glycosylation of proteins and lipids not only in cancer cells themselves, but also in cancer associated-stromal, endothelial and immune cells. These glycan alterations including increased frequency of β1,6-branched N-glycans and bisecting N-glycans, overexpression of tumor-associated mucins, preferred expression of T, Tn and sialyl-Tn antigen and altered surface sialylation, may contribute to tumor progression by masking or unmasking specific ligands for endogenous lectins, including members of the C-type lectin, siglec and galectin families. Differential expression of glycans or glycan-binding proteins could be capitalized for the identification of novel biomarkers and might provide novel opportunities for therapeutic intervention. This review focuses on the biological relevance of lectin-glycan interactions in the tumor microenvironment (mainly illustrated by the immunosuppressive and pro-angiogenic activities of galectin-1) and the design of functionalized nanoparticles for pharmacological delivery of multimeric glycans, lectins or selective inhibitors of lectin-glycan interactions with antitumor activity. © 2016 Elsevier Ltd. Fil:Bordoni, A.V. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Croci, D.O. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Soler-Illia, G.J.A.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2016 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10436618_v109_n_p45_Hockl http://hdl.handle.net/20.500.12110/paper_10436618_v109_n_p45_Hockl |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Cancer Drug delivery Galectins Glycobiology Nanotechnology Theranostics cancer vaccine dendrimer galectin galectin 1 glycan glycosphingolipid lectin liposome mucin nanocarrier nanoparticle proteoglycan sialic acid binding immunoglobulin like lectin Tn antigen vasculotropin nanoparticle cancer diagnosis cancer immunotherapy cancer prognosis cancer resistance cell surface glycobiology glycosylation human immune evasion metastasis molecular recognition molecularly targeted therapy nanotechnology nonhuman oncology priority journal Review sialylation theranostic nanomedicine tumor growth tumor microenvironment tumor vascularization animal metabolism nanotechnology Neoplasms Animals Glycosylation Humans Nanoparticles Nanotechnology Neoplasms Tumor Microenvironment |
| spellingShingle |
Cancer Drug delivery Galectins Glycobiology Nanotechnology Theranostics cancer vaccine dendrimer galectin galectin 1 glycan glycosphingolipid lectin liposome mucin nanocarrier nanoparticle proteoglycan sialic acid binding immunoglobulin like lectin Tn antigen vasculotropin nanoparticle cancer diagnosis cancer immunotherapy cancer prognosis cancer resistance cell surface glycobiology glycosylation human immune evasion metastasis molecular recognition molecularly targeted therapy nanotechnology nonhuman oncology priority journal Review sialylation theranostic nanomedicine tumor growth tumor microenvironment tumor vascularization animal metabolism nanotechnology Neoplasms Animals Glycosylation Humans Nanoparticles Nanotechnology Neoplasms Tumor Microenvironment Bordoni, Andrea Verónica Croci Russo, Diego Omar Soler Illia, Galo Juan de Avila Arturo Glyco-nano-oncology: Novel therapeutic opportunities by combining small and sweet |
| topic_facet |
Cancer Drug delivery Galectins Glycobiology Nanotechnology Theranostics cancer vaccine dendrimer galectin galectin 1 glycan glycosphingolipid lectin liposome mucin nanocarrier nanoparticle proteoglycan sialic acid binding immunoglobulin like lectin Tn antigen vasculotropin nanoparticle cancer diagnosis cancer immunotherapy cancer prognosis cancer resistance cell surface glycobiology glycosylation human immune evasion metastasis molecular recognition molecularly targeted therapy nanotechnology nonhuman oncology priority journal Review sialylation theranostic nanomedicine tumor growth tumor microenvironment tumor vascularization animal metabolism nanotechnology Neoplasms Animals Glycosylation Humans Nanoparticles Nanotechnology Neoplasms Tumor Microenvironment |
| description |
Recent efforts toward defining the molecular features of the tumor microenvironment have revealed dramatic changes in the expression of glycan-related genes including glycosyltransferases and glycosidases. These changes affect glycosylation of proteins and lipids not only in cancer cells themselves, but also in cancer associated-stromal, endothelial and immune cells. These glycan alterations including increased frequency of β1,6-branched N-glycans and bisecting N-glycans, overexpression of tumor-associated mucins, preferred expression of T, Tn and sialyl-Tn antigen and altered surface sialylation, may contribute to tumor progression by masking or unmasking specific ligands for endogenous lectins, including members of the C-type lectin, siglec and galectin families. Differential expression of glycans or glycan-binding proteins could be capitalized for the identification of novel biomarkers and might provide novel opportunities for therapeutic intervention. This review focuses on the biological relevance of lectin-glycan interactions in the tumor microenvironment (mainly illustrated by the immunosuppressive and pro-angiogenic activities of galectin-1) and the design of functionalized nanoparticles for pharmacological delivery of multimeric glycans, lectins or selective inhibitors of lectin-glycan interactions with antitumor activity. © 2016 Elsevier Ltd. |
| author |
Bordoni, Andrea Verónica Croci Russo, Diego Omar Soler Illia, Galo Juan de Avila Arturo |
| author_facet |
Bordoni, Andrea Verónica Croci Russo, Diego Omar Soler Illia, Galo Juan de Avila Arturo |
| author_sort |
Bordoni, Andrea Verónica |
| title |
Glyco-nano-oncology: Novel therapeutic opportunities by combining small and sweet |
| title_short |
Glyco-nano-oncology: Novel therapeutic opportunities by combining small and sweet |
| title_full |
Glyco-nano-oncology: Novel therapeutic opportunities by combining small and sweet |
| title_fullStr |
Glyco-nano-oncology: Novel therapeutic opportunities by combining small and sweet |
| title_full_unstemmed |
Glyco-nano-oncology: Novel therapeutic opportunities by combining small and sweet |
| title_sort |
glyco-nano-oncology: novel therapeutic opportunities by combining small and sweet |
| publishDate |
2016 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10436618_v109_n_p45_Hockl http://hdl.handle.net/20.500.12110/paper_10436618_v109_n_p45_Hockl |
| work_keys_str_mv |
AT bordoniandreaveronica glyconanooncologynoveltherapeuticopportunitiesbycombiningsmallandsweet AT crocirussodiegoomar glyconanooncologynoveltherapeuticopportunitiesbycombiningsmallandsweet AT solerilliagalojuandeavilaarturo glyconanooncologynoveltherapeuticopportunitiesbycombiningsmallandsweet |
| _version_ |
1768541808515612672 |