Cognitive enhancers versus addictive psychostimulants: The good and bad side of dopamine on prefrontal cortical circuits
In this review we describe how highly addictive psychostimulants such as cocaine and methamphetamine actions might underlie hypoexcitabilty in frontal cortical areas observed in clinical and preclinical models of psychostimulant abuse. We discuss new mechanisms that describe how increments on synapt...
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2016
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10436618_v109_n_p108_Bisagno http://hdl.handle.net/20.500.12110/paper_10436618_v109_n_p108_Bisagno |
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paper:paper_10436618_v109_n_p108_Bisagno2023-06-08T16:01:02Z Cognitive enhancers versus addictive psychostimulants: The good and bad side of dopamine on prefrontal cortical circuits Calcium channels Cocaine Dopamine Hyperpolarization-activated cation current Methamphetamine Methylphenidate Modafinil Prefrontal cortex AMPA receptor calcium channel L type calcium channel N type calcium channel P type calcium channel Q type calcium channel R type calcium channel T type calcium ion cocaine delayed rectifier potassium channel dopamine dopamine 1 receptor dopamine 2 receptor dopamine receptor dopamine transporter hyperpolarization activated cyclic nucleotide gated channel inwardly rectifying potassium channel metabotropic receptor methamphetamine methylphenidate modafinil n methyl dextro aspartic acid receptor noradrenalin transporter serotonin transporter voltage gated calcium channel benzhydryl derivative central stimulant agent cocaine dopamine methamphetamine methylphenidate modafinil nootropic agent brain function calcium transport cognition dopamine release dopaminergic nerve cell dopaminergic transmission drug dependence drug mechanism human nerve cell excitability nerve cell plasticity neuromodulation neuroprotection nonhuman prefrontal cortex priority journal protein expression protein function Review schizophrenia animal drug effects metabolism pathophysiology physiology prefrontal cortex Animals Benzhydryl Compounds Central Nervous System Stimulants Cocaine Dopamine Humans Methamphetamine Methylphenidate Nootropic Agents Prefrontal Cortex Substance-Related Disorders In this review we describe how highly addictive psychostimulants such as cocaine and methamphetamine actions might underlie hypoexcitabilty in frontal cortical areas observed in clinical and preclinical models of psychostimulant abuse. We discuss new mechanisms that describe how increments on synaptic dopamine release are linked to reduce calcium influx in both pre and postsynaptic compartments on medial PFC networks, therefore modulating synaptic integration and information. Sustained DA neuromodulation by addictive psychostimulants can "lock" frontal cortical networks in deficient states. On the other hand, other psychostimulants such as modafinil and methylphenidate are considered pharmacological neuroenhancement agents that are popular among healthy people seeking neuroenhancement. More clinical and preclinical research is needed to further clarify mechanisms of actions and physiological effects of cognitive enhancers which show an opposite pattern compared to chronic effect of addictive psychostimulants: they appear to increase cortical excitability. In conclusion, studies summarized here suggest that there is frontal cortex hypoactivity and deficient inhibitory control in drug-addicted individuals. Thus, additional research on physiological effects of cognitive enhancers like modafinil and methylphenidate seems necessary in order to expand current knowledge on mechanisms behind their therapeutic role in the treatment of addiction and other neuropsychiatric disorders. © 2016 Elsevier Ltd. All rights reserved. 2016 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10436618_v109_n_p108_Bisagno http://hdl.handle.net/20.500.12110/paper_10436618_v109_n_p108_Bisagno |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Calcium channels Cocaine Dopamine Hyperpolarization-activated cation current Methamphetamine Methylphenidate Modafinil Prefrontal cortex AMPA receptor calcium channel L type calcium channel N type calcium channel P type calcium channel Q type calcium channel R type calcium channel T type calcium ion cocaine delayed rectifier potassium channel dopamine dopamine 1 receptor dopamine 2 receptor dopamine receptor dopamine transporter hyperpolarization activated cyclic nucleotide gated channel inwardly rectifying potassium channel metabotropic receptor methamphetamine methylphenidate modafinil n methyl dextro aspartic acid receptor noradrenalin transporter serotonin transporter voltage gated calcium channel benzhydryl derivative central stimulant agent cocaine dopamine methamphetamine methylphenidate modafinil nootropic agent brain function calcium transport cognition dopamine release dopaminergic nerve cell dopaminergic transmission drug dependence drug mechanism human nerve cell excitability nerve cell plasticity neuromodulation neuroprotection nonhuman prefrontal cortex priority journal protein expression protein function Review schizophrenia animal drug effects metabolism pathophysiology physiology prefrontal cortex Animals Benzhydryl Compounds Central Nervous System Stimulants Cocaine Dopamine Humans Methamphetamine Methylphenidate Nootropic Agents Prefrontal Cortex Substance-Related Disorders |
| spellingShingle |
Calcium channels Cocaine Dopamine Hyperpolarization-activated cation current Methamphetamine Methylphenidate Modafinil Prefrontal cortex AMPA receptor calcium channel L type calcium channel N type calcium channel P type calcium channel Q type calcium channel R type calcium channel T type calcium ion cocaine delayed rectifier potassium channel dopamine dopamine 1 receptor dopamine 2 receptor dopamine receptor dopamine transporter hyperpolarization activated cyclic nucleotide gated channel inwardly rectifying potassium channel metabotropic receptor methamphetamine methylphenidate modafinil n methyl dextro aspartic acid receptor noradrenalin transporter serotonin transporter voltage gated calcium channel benzhydryl derivative central stimulant agent cocaine dopamine methamphetamine methylphenidate modafinil nootropic agent brain function calcium transport cognition dopamine release dopaminergic nerve cell dopaminergic transmission drug dependence drug mechanism human nerve cell excitability nerve cell plasticity neuromodulation neuroprotection nonhuman prefrontal cortex priority journal protein expression protein function Review schizophrenia animal drug effects metabolism pathophysiology physiology prefrontal cortex Animals Benzhydryl Compounds Central Nervous System Stimulants Cocaine Dopamine Humans Methamphetamine Methylphenidate Nootropic Agents Prefrontal Cortex Substance-Related Disorders Cognitive enhancers versus addictive psychostimulants: The good and bad side of dopamine on prefrontal cortical circuits |
| topic_facet |
Calcium channels Cocaine Dopamine Hyperpolarization-activated cation current Methamphetamine Methylphenidate Modafinil Prefrontal cortex AMPA receptor calcium channel L type calcium channel N type calcium channel P type calcium channel Q type calcium channel R type calcium channel T type calcium ion cocaine delayed rectifier potassium channel dopamine dopamine 1 receptor dopamine 2 receptor dopamine receptor dopamine transporter hyperpolarization activated cyclic nucleotide gated channel inwardly rectifying potassium channel metabotropic receptor methamphetamine methylphenidate modafinil n methyl dextro aspartic acid receptor noradrenalin transporter serotonin transporter voltage gated calcium channel benzhydryl derivative central stimulant agent cocaine dopamine methamphetamine methylphenidate modafinil nootropic agent brain function calcium transport cognition dopamine release dopaminergic nerve cell dopaminergic transmission drug dependence drug mechanism human nerve cell excitability nerve cell plasticity neuromodulation neuroprotection nonhuman prefrontal cortex priority journal protein expression protein function Review schizophrenia animal drug effects metabolism pathophysiology physiology prefrontal cortex Animals Benzhydryl Compounds Central Nervous System Stimulants Cocaine Dopamine Humans Methamphetamine Methylphenidate Nootropic Agents Prefrontal Cortex Substance-Related Disorders |
| description |
In this review we describe how highly addictive psychostimulants such as cocaine and methamphetamine actions might underlie hypoexcitabilty in frontal cortical areas observed in clinical and preclinical models of psychostimulant abuse. We discuss new mechanisms that describe how increments on synaptic dopamine release are linked to reduce calcium influx in both pre and postsynaptic compartments on medial PFC networks, therefore modulating synaptic integration and information. Sustained DA neuromodulation by addictive psychostimulants can "lock" frontal cortical networks in deficient states. On the other hand, other psychostimulants such as modafinil and methylphenidate are considered pharmacological neuroenhancement agents that are popular among healthy people seeking neuroenhancement. More clinical and preclinical research is needed to further clarify mechanisms of actions and physiological effects of cognitive enhancers which show an opposite pattern compared to chronic effect of addictive psychostimulants: they appear to increase cortical excitability. In conclusion, studies summarized here suggest that there is frontal cortex hypoactivity and deficient inhibitory control in drug-addicted individuals. Thus, additional research on physiological effects of cognitive enhancers like modafinil and methylphenidate seems necessary in order to expand current knowledge on mechanisms behind their therapeutic role in the treatment of addiction and other neuropsychiatric disorders. © 2016 Elsevier Ltd. All rights reserved. |
| title |
Cognitive enhancers versus addictive psychostimulants: The good and bad side of dopamine on prefrontal cortical circuits |
| title_short |
Cognitive enhancers versus addictive psychostimulants: The good and bad side of dopamine on prefrontal cortical circuits |
| title_full |
Cognitive enhancers versus addictive psychostimulants: The good and bad side of dopamine on prefrontal cortical circuits |
| title_fullStr |
Cognitive enhancers versus addictive psychostimulants: The good and bad side of dopamine on prefrontal cortical circuits |
| title_full_unstemmed |
Cognitive enhancers versus addictive psychostimulants: The good and bad side of dopamine on prefrontal cortical circuits |
| title_sort |
cognitive enhancers versus addictive psychostimulants: the good and bad side of dopamine on prefrontal cortical circuits |
| publishDate |
2016 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10436618_v109_n_p108_Bisagno http://hdl.handle.net/20.500.12110/paper_10436618_v109_n_p108_Bisagno |
| _version_ |
1768542467702915072 |