Comment on "binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach"

The present manuscript is a comment on the article entitled "Binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach" by Sarita Sarkar and Kakali Bhadra (2014) [1]. In their article, the authors reported the chemical structure as well as the absorption spectra of harma...

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Publicado:	2014
Materias:	Acid-base equilibria Harmalol β-carbolines DNA harmalol harmaline absorption acid base balance article calorimetry chemical structure DNA binding interactions with DNA pH photochemistry priority journal Harmaline
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10111344_v136_n_p26_Alomar http://hdl.handle.net/20.500.12110/paper_10111344_v136_n_p26_Alomar
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_10111344_v136_n_p26_Alomar
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spelling	paper:paper_10111344_v136_n_p26_Alomar2023-06-08T15:59:38Z Comment on "binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach" Acid-base equilibria Harmalol β-carbolines DNA harmalol DNA harmaline absorption acid base balance article calorimetry chemical structure DNA binding interactions with DNA pH photochemistry priority journal DNA Harmaline The present manuscript is a comment on the article entitled "Binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach" by Sarita Sarkar and Kakali Bhadra (2014) [1]. In their article, the authors reported the chemical structure as well as the absorption spectra of harmalol at different pH. On the bases of the previous publications and our own present results, the assignment of the number of the acid-base species and the corresponding pKa values, as well as the chemical structure for each species are erroneous. These facts have strong effect on the conclusions reached by the authors, in terms of the interaction with DNA. © 2014 Elsevier B.V. All rights reserved. 2014 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10111344_v136_n_p26_Alomar http://hdl.handle.net/20.500.12110/paper_10111344_v136_n_p26_Alomar
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Acid-base equilibria Harmalol β-carbolines DNA harmalol DNA harmaline absorption acid base balance article calorimetry chemical structure DNA binding interactions with DNA pH photochemistry priority journal DNA Harmaline
spellingShingle	Acid-base equilibria Harmalol β-carbolines DNA harmalol DNA harmaline absorption acid base balance article calorimetry chemical structure DNA binding interactions with DNA pH photochemistry priority journal DNA Harmaline Comment on "binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach"
topic_facet	Acid-base equilibria Harmalol β-carbolines DNA harmalol DNA harmaline absorption acid base balance article calorimetry chemical structure DNA binding interactions with DNA pH photochemistry priority journal DNA Harmaline
description	The present manuscript is a comment on the article entitled "Binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach" by Sarita Sarkar and Kakali Bhadra (2014) [1]. In their article, the authors reported the chemical structure as well as the absorption spectra of harmalol at different pH. On the bases of the previous publications and our own present results, the assignment of the number of the acid-base species and the corresponding pKa values, as well as the chemical structure for each species are erroneous. These facts have strong effect on the conclusions reached by the authors, in terms of the interaction with DNA. © 2014 Elsevier B.V. All rights reserved.
title	Comment on "binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach"
title_short	Comment on "binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach"
title_full	Comment on "binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach"
title_fullStr	Comment on "binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach"
title_full_unstemmed	Comment on "binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach"
title_sort	comment on "binding of alkaloid harmalol to dna: photophysical and calorimetric approach"
publishDate	2014
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10111344_v136_n_p26_Alomar http://hdl.handle.net/20.500.12110/paper_10111344_v136_n_p26_Alomar
_version_	1768542850501312512

Comment on "binding of alkaloid harmalol to DNA: Photophysical and calorimetric approach"

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