The carboxy terminal domain of RNA polymerase II and alternative splicing

Alternative splicing is controlled by cis-regulatory sequences present in the pre-mRNA and their cognate trans-acting factors, as well as by its coupling to RNA polymerase II (pol II) transcription. A unique feature of this polymerase is the presence of a highly repetitive carboxy terminal domain (C...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Muñoz, Manuel Javier, de la Mata, Manuel, Kornblihtt, Alberto Rodolfo
Publicado: 2010
Materias:
cyclin dependent kinase 7
RNA polymerase II
small nuclear ribonucleoprotein
alternative RNA splicing
carboxy terminal sequence
chromatin assembly and disassembly
consensus sequence
molecular dynamics
nonhuman
priority journal
protein phosphorylation
protein processing
protein protein interaction
review
RNA capping
RNA processing
RNA translation
spliceosome
transcription regulation
Alternative Splicing
Animals
Humans
Phosphorylation
Protein Processing, Post-Translational
RNA Polymerase II
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09680004_v35_n9_p497_Munoz
http://hdl.handle.net/20.500.12110/paper_09680004_v35_n9_p497_Munoz
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Alternative splicing is controlled by cis-regulatory sequences present in the pre-mRNA and their cognate trans-acting factors, as well as by its coupling to RNA polymerase II (pol II) transcription. A unique feature of this polymerase is the presence of a highly repetitive carboxy terminal domain (CTD), which is subject to multiple regulatory post-translational modifications. CTD phosphorylation events affect the transcriptional properties of pol II and the outcome of co-transcriptional alternative splicing by mediating the effects of splicing factors and by modulating transcription elongation rates. Here, we discuss various examples of involvement of the CTD in alternative splicing regulation as well as the current methodological limitations in deciphering the detailed mechanisms of this process. © 2010 Elsevier Ltd.

Ejemplares similares