The carboxy terminal domain of RNA polymerase II and alternative splicing

Alternative splicing is controlled by cis-regulatory sequences present in the pre-mRNA and their cognate trans-acting factors, as well as by its coupling to RNA polymerase II (pol II) transcription. A unique feature of this polymerase is the presence of a highly repetitive carboxy terminal domain (C...

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Autores principales: Muñoz, Manuel Javier, de la Mata, Manuel, Kornblihtt, Alberto Rodolfo
Publicado: 2010
Materias:
cyclin dependent kinase 7
RNA polymerase II
small nuclear ribonucleoprotein
alternative RNA splicing
carboxy terminal sequence
chromatin assembly and disassembly
consensus sequence
molecular dynamics
nonhuman
priority journal
protein phosphorylation
protein processing
protein protein interaction
review
RNA capping
RNA processing
RNA translation
spliceosome
transcription regulation
Alternative Splicing
Animals
Humans
Phosphorylation
Protein Processing, Post-Translational
RNA Polymerase II
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09680004_v35_n9_p497_Munoz
http://hdl.handle.net/20.500.12110/paper_09680004_v35_n9_p497_Munoz
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_09680004_v35_n9_p497_Munoz
record_format dspace
spelling paper:paper_09680004_v35_n9_p497_Munoz2023-06-08T15:58:49Z The carboxy terminal domain of RNA polymerase II and alternative splicing Muñoz, Manuel Javier de la Mata, Manuel Kornblihtt, Alberto Rodolfo cyclin dependent kinase 7 RNA polymerase II small nuclear ribonucleoprotein alternative RNA splicing carboxy terminal sequence chromatin assembly and disassembly consensus sequence molecular dynamics nonhuman priority journal protein phosphorylation protein processing protein protein interaction review RNA capping RNA processing RNA translation spliceosome transcription regulation Alternative Splicing Animals Humans Phosphorylation Protein Processing, Post-Translational RNA Polymerase II Alternative splicing is controlled by cis-regulatory sequences present in the pre-mRNA and their cognate trans-acting factors, as well as by its coupling to RNA polymerase II (pol II) transcription. A unique feature of this polymerase is the presence of a highly repetitive carboxy terminal domain (CTD), which is subject to multiple regulatory post-translational modifications. CTD phosphorylation events affect the transcriptional properties of pol II and the outcome of co-transcriptional alternative splicing by mediating the effects of splicing factors and by modulating transcription elongation rates. Here, we discuss various examples of involvement of the CTD in alternative splicing regulation as well as the current methodological limitations in deciphering the detailed mechanisms of this process. © 2010 Elsevier Ltd. Fil:Muñoz, M.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:de la Mata, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Kornblihtt, A.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2010 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09680004_v35_n9_p497_Munoz http://hdl.handle.net/20.500.12110/paper_09680004_v35_n9_p497_Munoz
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic cyclin dependent kinase 7
RNA polymerase II
small nuclear ribonucleoprotein
alternative RNA splicing
carboxy terminal sequence
chromatin assembly and disassembly
consensus sequence
molecular dynamics
nonhuman
priority journal
protein phosphorylation
protein processing
protein protein interaction
review
RNA capping
RNA processing
RNA translation
spliceosome
transcription regulation
Alternative Splicing
Animals
Humans
Phosphorylation
Protein Processing, Post-Translational
RNA Polymerase II
spellingShingle cyclin dependent kinase 7
RNA polymerase II
small nuclear ribonucleoprotein
alternative RNA splicing
carboxy terminal sequence
chromatin assembly and disassembly
consensus sequence
molecular dynamics
nonhuman
priority journal
protein phosphorylation
protein processing
protein protein interaction
review
RNA capping
RNA processing
RNA translation
spliceosome
transcription regulation
Alternative Splicing
Animals
Humans
Phosphorylation
Protein Processing, Post-Translational
RNA Polymerase II
Muñoz, Manuel Javier
de la Mata, Manuel
Kornblihtt, Alberto Rodolfo
The carboxy terminal domain of RNA polymerase II and alternative splicing
topic_facet cyclin dependent kinase 7
RNA polymerase II
small nuclear ribonucleoprotein
alternative RNA splicing
carboxy terminal sequence
chromatin assembly and disassembly
consensus sequence
molecular dynamics
nonhuman
priority journal
protein phosphorylation
protein processing
protein protein interaction
review
RNA capping
RNA processing
RNA translation
spliceosome
transcription regulation
Alternative Splicing
Animals
Humans
Phosphorylation
Protein Processing, Post-Translational
RNA Polymerase II
description Alternative splicing is controlled by cis-regulatory sequences present in the pre-mRNA and their cognate trans-acting factors, as well as by its coupling to RNA polymerase II (pol II) transcription. A unique feature of this polymerase is the presence of a highly repetitive carboxy terminal domain (CTD), which is subject to multiple regulatory post-translational modifications. CTD phosphorylation events affect the transcriptional properties of pol II and the outcome of co-transcriptional alternative splicing by mediating the effects of splicing factors and by modulating transcription elongation rates. Here, we discuss various examples of involvement of the CTD in alternative splicing regulation as well as the current methodological limitations in deciphering the detailed mechanisms of this process. © 2010 Elsevier Ltd.
author Muñoz, Manuel Javier
de la Mata, Manuel
Kornblihtt, Alberto Rodolfo
author_facet Muñoz, Manuel Javier
de la Mata, Manuel
Kornblihtt, Alberto Rodolfo
author_sort Muñoz, Manuel Javier
title The carboxy terminal domain of RNA polymerase II and alternative splicing
title_short The carboxy terminal domain of RNA polymerase II and alternative splicing
title_full The carboxy terminal domain of RNA polymerase II and alternative splicing
title_fullStr The carboxy terminal domain of RNA polymerase II and alternative splicing
title_full_unstemmed The carboxy terminal domain of RNA polymerase II and alternative splicing
title_sort carboxy terminal domain of rna polymerase ii and alternative splicing
publishDate 2010
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09680004_v35_n9_p497_Munoz
http://hdl.handle.net/20.500.12110/paper_09680004_v35_n9_p497_Munoz
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AT kornblihttalbertorodolfo thecarboxyterminaldomainofrnapolymeraseiiandalternativesplicing
AT munozmanueljavier carboxyterminaldomainofrnapolymeraseiiandalternativesplicing
AT delamatamanuel carboxyterminaldomainofrnapolymeraseiiandalternativesplicing
AT kornblihttalbertorodolfo carboxyterminaldomainofrnapolymeraseiiandalternativesplicing
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