The structure and evolution of cisregulatory regions: The shavenbaby story
In this paper, we provide a historical account of the contribution of a single line of research to our current understanding of the structure of cis-regulatory regions and the genetic basis for morphological evolution. We revisit the experiments that shed light on the evolution of larval cuticular p...
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2013
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09628436_v368_n1632_p_Stern http://hdl.handle.net/20.500.12110/paper_09628436_v368_n1632_p_Stern |
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paper:paper_09628436_v368_n1632_p_Stern2023-06-08T15:58:03Z The structure and evolution of cisregulatory regions: The shavenbaby story Cis-regulatory evolution Cis-regulatory structure Evolution of enhancer function Morphological change Shavenbaby gene cuticle evolutionary biology genetic analysis hair molecular analysis morphogenesis morphology DNA binding protein Drosophila protein ovo protein, Drosophila transcription factor animal cis-regulatory evolution cis-regulatory structure Drosophila evolution of enhancer function gene expression regulation genetics growth, development and aging metabolism molecular evolution morphogenesis morphological change prenatal development regulatory sequence review shavenbaby gene species difference trichome cis-regulatory evolution cis-regulatory structure evolution of enhancer function morphological change shavenbaby gene Animals DNA-Binding Proteins Drosophila Drosophila Proteins Evolution, Molecular Gene Expression Regulation, Developmental Morphogenesis Regulatory Sequences, Nucleic Acid Species Specificity Transcription Factors Trichomes In this paper, we provide a historical account of the contribution of a single line of research to our current understanding of the structure of cis-regulatory regions and the genetic basis for morphological evolution. We revisit the experiments that shed light on the evolution of larval cuticular patterns within the genus Drosophila and the evolution and structure of the shavenbaby gene. We describe the experiments that led to the discovery that multiple genetic changes in the cis-regulatory region of shavenbaby caused the loss of dorsal cuticular hairs (quaternary trichomes) in first instar larvae of Drosophila sechellia. We also discuss the experiments that showed that the convergent loss of quaternary trichomes in D. sechellia and Drosophila ezoana was generated by parallel genetic changes in orthologous enhancers of shavenbaby. We discuss the observation that multiple shavenbaby enhancers drive overlapping patterns of expression in the embryo and that these apparently redundant enhancers ensure robust shavenbaby expression and trichome morphogenesis under stressful conditions. All together, these data, collected over 13 years, provide a fundamental case study in the fields of gene regulation and morphological evolution, and highlight the importance of prolonged, detailed studies of single genes. 2013 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09628436_v368_n1632_p_Stern http://hdl.handle.net/20.500.12110/paper_09628436_v368_n1632_p_Stern |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Cis-regulatory evolution Cis-regulatory structure Evolution of enhancer function Morphological change Shavenbaby gene cuticle evolutionary biology genetic analysis hair molecular analysis morphogenesis morphology DNA binding protein Drosophila protein ovo protein, Drosophila transcription factor animal cis-regulatory evolution cis-regulatory structure Drosophila evolution of enhancer function gene expression regulation genetics growth, development and aging metabolism molecular evolution morphogenesis morphological change prenatal development regulatory sequence review shavenbaby gene species difference trichome cis-regulatory evolution cis-regulatory structure evolution of enhancer function morphological change shavenbaby gene Animals DNA-Binding Proteins Drosophila Drosophila Proteins Evolution, Molecular Gene Expression Regulation, Developmental Morphogenesis Regulatory Sequences, Nucleic Acid Species Specificity Transcription Factors Trichomes |
| spellingShingle |
Cis-regulatory evolution Cis-regulatory structure Evolution of enhancer function Morphological change Shavenbaby gene cuticle evolutionary biology genetic analysis hair molecular analysis morphogenesis morphology DNA binding protein Drosophila protein ovo protein, Drosophila transcription factor animal cis-regulatory evolution cis-regulatory structure Drosophila evolution of enhancer function gene expression regulation genetics growth, development and aging metabolism molecular evolution morphogenesis morphological change prenatal development regulatory sequence review shavenbaby gene species difference trichome cis-regulatory evolution cis-regulatory structure evolution of enhancer function morphological change shavenbaby gene Animals DNA-Binding Proteins Drosophila Drosophila Proteins Evolution, Molecular Gene Expression Regulation, Developmental Morphogenesis Regulatory Sequences, Nucleic Acid Species Specificity Transcription Factors Trichomes The structure and evolution of cisregulatory regions: The shavenbaby story |
| topic_facet |
Cis-regulatory evolution Cis-regulatory structure Evolution of enhancer function Morphological change Shavenbaby gene cuticle evolutionary biology genetic analysis hair molecular analysis morphogenesis morphology DNA binding protein Drosophila protein ovo protein, Drosophila transcription factor animal cis-regulatory evolution cis-regulatory structure Drosophila evolution of enhancer function gene expression regulation genetics growth, development and aging metabolism molecular evolution morphogenesis morphological change prenatal development regulatory sequence review shavenbaby gene species difference trichome cis-regulatory evolution cis-regulatory structure evolution of enhancer function morphological change shavenbaby gene Animals DNA-Binding Proteins Drosophila Drosophila Proteins Evolution, Molecular Gene Expression Regulation, Developmental Morphogenesis Regulatory Sequences, Nucleic Acid Species Specificity Transcription Factors Trichomes |
| description |
In this paper, we provide a historical account of the contribution of a single line of research to our current understanding of the structure of cis-regulatory regions and the genetic basis for morphological evolution. We revisit the experiments that shed light on the evolution of larval cuticular patterns within the genus Drosophila and the evolution and structure of the shavenbaby gene. We describe the experiments that led to the discovery that multiple genetic changes in the cis-regulatory region of shavenbaby caused the loss of dorsal cuticular hairs (quaternary trichomes) in first instar larvae of Drosophila sechellia. We also discuss the experiments that showed that the convergent loss of quaternary trichomes in D. sechellia and Drosophila ezoana was generated by parallel genetic changes in orthologous enhancers of shavenbaby. We discuss the observation that multiple shavenbaby enhancers drive overlapping patterns of expression in the embryo and that these apparently redundant enhancers ensure robust shavenbaby expression and trichome morphogenesis under stressful conditions. All together, these data, collected over 13 years, provide a fundamental case study in the fields of gene regulation and morphological evolution, and highlight the importance of prolonged, detailed studies of single genes. |
| title |
The structure and evolution of cisregulatory regions: The shavenbaby story |
| title_short |
The structure and evolution of cisregulatory regions: The shavenbaby story |
| title_full |
The structure and evolution of cisregulatory regions: The shavenbaby story |
| title_fullStr |
The structure and evolution of cisregulatory regions: The shavenbaby story |
| title_full_unstemmed |
The structure and evolution of cisregulatory regions: The shavenbaby story |
| title_sort |
structure and evolution of cisregulatory regions: the shavenbaby story |
| publishDate |
2013 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09628436_v368_n1632_p_Stern http://hdl.handle.net/20.500.12110/paper_09628436_v368_n1632_p_Stern |
| _version_ |
1768545747356090368 |