Biological evaluation of two potent inhibitors of Trypanosoma cruzi epimastigotes against the intracellular form of the parasite

(±)-S-Ethyl-[3,7,11]-trimethyl-10,11-epoxy-2E,6E-dien-1-yl]-thiolcarb onate (1) and 4-phenoxyphenoxy ethyl tetrahydropyranyl ether (2) were shown to be very active antireplicative agents against intracellular Trypanosoma cruzi amastigotes in in vitro assays. Both of them had previously presented hig...

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Guardado en:
Detalles Bibliográficos
Publicado: 1996
Materias:
antiparasitic agent
animal cell
article
cell proliferation
controlled study
in vitro study
myoblast
nonhuman
trypanosoma cruzi
Animalia
Trypanosoma
Trypanosoma cruzi
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0960894X_v6_n22_p2783_Rodriguez
http://hdl.handle.net/20.500.12110/paper_0960894X_v6_n22_p2783_Rodriguez
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:(±)-S-Ethyl-[3,7,11]-trimethyl-10,11-epoxy-2E,6E-dien-1-yl]-thiolcarb onate (1) and 4-phenoxyphenoxy ethyl tetrahydropyranyl ether (2) were shown to be very active antireplicative agents against intracellular Trypanosoma cruzi amastigotes in in vitro assays. Both of them had previously presented high biological activity as growth inhibitors of the epimastigote form of the parasite.

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