Oral aluminum administration to rats with normal renal function. 1. Impairment of erythropoiesis

Aluminum (Al) toxicity has been mainly investigated in uremic patients although healthy subjects and patients without renal insufficiency are not exempt from its potential deleterious effects. This experimental study aims to elucidate the action of different doses of Al citrate on in vivo erythropoi...

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Autores principales:	Garbosa, Graciela, Gálvez, Gladys Alicia, Nesse, Alcira Beatriz
Publicado:	1998
Materias:	Aluminium toxicity Aluminum CFU-E Mean red blood-cell life-span Median osmotic fragility aluminum aluminum citrate drinking water hemoglobin animal cell animal experiment article blood level bone level bone marrow colony forming unit E controlled study dyserythropoiesis erythrocyte fragility erythroid precursor cell hematocrit hemoglobin determination kidney function male nephrotoxicity nonhuman priority journal rat
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09603271_v17_n6_p312_Garbossa http://hdl.handle.net/20.500.12110/paper_09603271_v17_n6_p312_Garbossa
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_09603271_v17_n6_p312_Garbossa
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spelling	paper:paper_09603271_v17_n6_p312_Garbossa2025-07-30T18:33:47Z Oral aluminum administration to rats with normal renal function. 1. Impairment of erythropoiesis Garbosa, Graciela Gálvez, Gladys Alicia Nesse, Alcira Beatriz Aluminium toxicity Aluminum CFU-E Mean red blood-cell life-span Median osmotic fragility aluminum aluminum citrate drinking water hemoglobin animal cell animal experiment article blood level bone level bone marrow colony forming unit E controlled study dyserythropoiesis erythrocyte fragility erythroid precursor cell hematocrit hemoglobin determination kidney function male nephrotoxicity nonhuman priority journal rat Aluminum (Al) toxicity has been mainly investigated in uremic patients although healthy subjects and patients without renal insufficiency are not exempt from its potential deleterious effects. This experimental study aims to elucidate the action of different doses of Al citrate on in vivo erythropoiesis and find out whether the metal exerts a local toxic effect upon the bone marrow late erythroid progenitor cells. The groups in the first experimental series were: C1 (n = 5) controls and T(Al-1) (n = 5) rats receiving 1 μmol Al citrate/g body weight/day by gavage. Colony-forming units-erythroid (CFU-E) deveIopment was inhibited in the T(Al-1) group, but the median osmotic fragility (MOF) and hematocrit (Ht) values were similar to those of the C1 group. The groups in the second series were C2 (n = 5) controls and T(Al-2) (n = 5) rats receiving Al citrate in drinking water (100 mmol/l). The T(Al-2) group showed decreased Ht, hemoglobin concentration, MOF and red blood-cell life-span values (P < 0.05), and a marked inhibition of the CFU-E development (P < 0.01). Serum and bone Al concentrations were increased in both Al-treated groups (P < 0.01). There was a dose-dependent increase in bone Al levels (P < 0.01) and a dose-dependent decrease of CFU-E development (P < 0.05). The CFU-E development was inversely correlated with the bone Al content (r = -0.79; P < 0.05). The results demonstrate that even very low doses of Al citrate impair erythropoiesis in vivo and higher doses exert a deleterious action on both CFU-E and mature erythrocytes. This might show a local effect of Al on CFU-E caused by the bone sensitivity to the metal accumulation. Fil:Garbossa, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Gálvez, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Nesse, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1998 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09603271_v17_n6_p312_Garbossa http://hdl.handle.net/20.500.12110/paper_09603271_v17_n6_p312_Garbossa
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Aluminium toxicity Aluminum CFU-E Mean red blood-cell life-span Median osmotic fragility aluminum aluminum citrate drinking water hemoglobin animal cell animal experiment article blood level bone level bone marrow colony forming unit E controlled study dyserythropoiesis erythrocyte fragility erythroid precursor cell hematocrit hemoglobin determination kidney function male nephrotoxicity nonhuman priority journal rat
spellingShingle	Aluminium toxicity Aluminum CFU-E Mean red blood-cell life-span Median osmotic fragility aluminum aluminum citrate drinking water hemoglobin animal cell animal experiment article blood level bone level bone marrow colony forming unit E controlled study dyserythropoiesis erythrocyte fragility erythroid precursor cell hematocrit hemoglobin determination kidney function male nephrotoxicity nonhuman priority journal rat Garbosa, Graciela Gálvez, Gladys Alicia Nesse, Alcira Beatriz Oral aluminum administration to rats with normal renal function. 1. Impairment of erythropoiesis
topic_facet	Aluminium toxicity Aluminum CFU-E Mean red blood-cell life-span Median osmotic fragility aluminum aluminum citrate drinking water hemoglobin animal cell animal experiment article blood level bone level bone marrow colony forming unit E controlled study dyserythropoiesis erythrocyte fragility erythroid precursor cell hematocrit hemoglobin determination kidney function male nephrotoxicity nonhuman priority journal rat
description	Aluminum (Al) toxicity has been mainly investigated in uremic patients although healthy subjects and patients without renal insufficiency are not exempt from its potential deleterious effects. This experimental study aims to elucidate the action of different doses of Al citrate on in vivo erythropoiesis and find out whether the metal exerts a local toxic effect upon the bone marrow late erythroid progenitor cells. The groups in the first experimental series were: C1 (n = 5) controls and T(Al-1) (n = 5) rats receiving 1 μmol Al citrate/g body weight/day by gavage. Colony-forming units-erythroid (CFU-E) deveIopment was inhibited in the T(Al-1) group, but the median osmotic fragility (MOF) and hematocrit (Ht) values were similar to those of the C1 group. The groups in the second series were C2 (n = 5) controls and T(Al-2) (n = 5) rats receiving Al citrate in drinking water (100 mmol/l). The T(Al-2) group showed decreased Ht, hemoglobin concentration, MOF and red blood-cell life-span values (P < 0.05), and a marked inhibition of the CFU-E development (P < 0.01). Serum and bone Al concentrations were increased in both Al-treated groups (P < 0.01). There was a dose-dependent increase in bone Al levels (P < 0.01) and a dose-dependent decrease of CFU-E development (P < 0.05). The CFU-E development was inversely correlated with the bone Al content (r = -0.79; P < 0.05). The results demonstrate that even very low doses of Al citrate impair erythropoiesis in vivo and higher doses exert a deleterious action on both CFU-E and mature erythrocytes. This might show a local effect of Al on CFU-E caused by the bone sensitivity to the metal accumulation.
author	Garbosa, Graciela Gálvez, Gladys Alicia Nesse, Alcira Beatriz
author_facet	Garbosa, Graciela Gálvez, Gladys Alicia Nesse, Alcira Beatriz
author_sort	Garbosa, Graciela
title	Oral aluminum administration to rats with normal renal function. 1. Impairment of erythropoiesis
title_short	Oral aluminum administration to rats with normal renal function. 1. Impairment of erythropoiesis
title_full	Oral aluminum administration to rats with normal renal function. 1. Impairment of erythropoiesis
title_fullStr	Oral aluminum administration to rats with normal renal function. 1. Impairment of erythropoiesis
title_full_unstemmed	Oral aluminum administration to rats with normal renal function. 1. Impairment of erythropoiesis
title_sort	oral aluminum administration to rats with normal renal function. 1. impairment of erythropoiesis
publishDate	1998
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09603271_v17_n6_p312_Garbossa http://hdl.handle.net/20.500.12110/paper_09603271_v17_n6_p312_Garbossa
work_keys_str_mv	AT garbosagraciela oralaluminumadministrationtoratswithnormalrenalfunction1impairmentoferythropoiesis AT galvezgladysalicia oralaluminumadministrationtoratswithnormalrenalfunction1impairmentoferythropoiesis AT nessealcirabeatriz oralaluminumadministrationtoratswithnormalrenalfunction1impairmentoferythropoiesis
_version_	1840325383469137920

Oral aluminum administration to rats with normal renal function. 1. Impairment of erythropoiesis

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