Galectin-8: A matricellular lectin with key roles in angiogenesis

Galectin-8 (gal-8) is a "tandem-repeat"-type galectin, containing two carbohydrate recognition domains connected by a linker peptide. gal-8 is expressed both in the cytoplasm and nucleus in vascular endothelial cells (ECs) from normal and tumor-associated blood vessels, and in lymphatic en...

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Detalles Bibliográficos
Autores principales:	Troncoso, María Fernanda, Elola, María Teresa
Publicado:	2014
Materias:	Angiogenesis CD166 Endothelium Galectin-8 activated leukocyte cell adhesion molecule galectin 8 Hermes antigen integrin podoplanin ALCAM protein, human fetoprotein galectin leukocyte antigen LGALS8 protein, human membrane protein nerve cell adhesion molecule PDPN protein, human angiogenesis Article cell adhesion cell migration endothelium cell human lymph vessel endothelium lymphangiogenesis nonhuman priority journal protein protein interaction serum vascular endothelium carcinogenesis extracellular matrix genetics metabolism metastasis neoplasm neovascularization (pathology) pathology Antigens, CD Carcinogenesis Cell Adhesion Cell Adhesion Molecules, Neuronal Endothelial Cells Extracellular Matrix Fetal Proteins Galectins Humans Membrane Glycoproteins Neoplasm Metastasis Neoplasms Neovascularization, Pathologic
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09596658_v24_n10_p907_Troncoso http://hdl.handle.net/20.500.12110/paper_09596658_v24_n10_p907_Troncoso
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_09596658_v24_n10_p907_Troncoso
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spelling	paper:paper_09596658_v24_n10_p907_Troncoso2023-06-08T15:57:05Z Galectin-8: A matricellular lectin with key roles in angiogenesis Troncoso, María Fernanda Elola, María Teresa Angiogenesis CD166 Endothelium Galectin-8 activated leukocyte cell adhesion molecule galectin 8 Hermes antigen integrin podoplanin ALCAM protein, human fetoprotein galectin leukocyte antigen LGALS8 protein, human membrane protein nerve cell adhesion molecule PDPN protein, human angiogenesis Article cell adhesion cell migration endothelium cell human lymph vessel endothelium lymphangiogenesis nonhuman priority journal protein protein interaction serum vascular endothelium carcinogenesis extracellular matrix genetics metabolism metastasis neoplasm neovascularization (pathology) pathology Antigens, CD Carcinogenesis Cell Adhesion Cell Adhesion Molecules, Neuronal Endothelial Cells Extracellular Matrix Fetal Proteins Galectins Humans Membrane Glycoproteins Neoplasm Metastasis Neoplasms Neovascularization, Pathologic Galectin-8 (gal-8) is a "tandem-repeat"-type galectin, containing two carbohydrate recognition domains connected by a linker peptide. gal-8 is expressed both in the cytoplasm and nucleus in vascular endothelial cells (ECs) from normal and tumor-associated blood vessels, and in lymphatic endothelial cells. Herein, we describe a novel role for gal-8 in the regulation of vascular and lymphatic angiogenesis and provide evidence of its critical implications in tumor biology. Functional assays revealed central roles for gal-8 in the control of capillary-tube formation, EC migration and in vivo angiogenesis. So far, two endothelial ligands have been described for gal-8, namely podoplanin in lymphatic vessels and CD166 (ALCAM, activated leukocyte cell adhesion molecule) in vascular ECs. Other related gal-8 functions are also summarized here, including cell adhesion and migration, which collectively demonstrate the multi-functionality of this complex lectin. Thus, gal-8 is an important component of the angiogenesis network, and an essential molecule in the extracellular matrix by providing molecular anchoring to this surrounding matrix. The implications of gal-8 in tumor angiogenesis remain to be further explored, but it is exciting to speculate that modulating gal-8-glycan interactions could be used to block lymphatic-vascular connections vital for metastasis. © The Author 2014. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. Fil:Troncoso, M.F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Elola, M.T. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2014 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09596658_v24_n10_p907_Troncoso http://hdl.handle.net/20.500.12110/paper_09596658_v24_n10_p907_Troncoso
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Angiogenesis CD166 Endothelium Galectin-8 activated leukocyte cell adhesion molecule galectin 8 Hermes antigen integrin podoplanin ALCAM protein, human fetoprotein galectin leukocyte antigen LGALS8 protein, human membrane protein nerve cell adhesion molecule PDPN protein, human angiogenesis Article cell adhesion cell migration endothelium cell human lymph vessel endothelium lymphangiogenesis nonhuman priority journal protein protein interaction serum vascular endothelium carcinogenesis extracellular matrix genetics metabolism metastasis neoplasm neovascularization (pathology) pathology Antigens, CD Carcinogenesis Cell Adhesion Cell Adhesion Molecules, Neuronal Endothelial Cells Extracellular Matrix Fetal Proteins Galectins Humans Membrane Glycoproteins Neoplasm Metastasis Neoplasms Neovascularization, Pathologic
spellingShingle	Angiogenesis CD166 Endothelium Galectin-8 activated leukocyte cell adhesion molecule galectin 8 Hermes antigen integrin podoplanin ALCAM protein, human fetoprotein galectin leukocyte antigen LGALS8 protein, human membrane protein nerve cell adhesion molecule PDPN protein, human angiogenesis Article cell adhesion cell migration endothelium cell human lymph vessel endothelium lymphangiogenesis nonhuman priority journal protein protein interaction serum vascular endothelium carcinogenesis extracellular matrix genetics metabolism metastasis neoplasm neovascularization (pathology) pathology Antigens, CD Carcinogenesis Cell Adhesion Cell Adhesion Molecules, Neuronal Endothelial Cells Extracellular Matrix Fetal Proteins Galectins Humans Membrane Glycoproteins Neoplasm Metastasis Neoplasms Neovascularization, Pathologic Troncoso, María Fernanda Elola, María Teresa Galectin-8: A matricellular lectin with key roles in angiogenesis
topic_facet	Angiogenesis CD166 Endothelium Galectin-8 activated leukocyte cell adhesion molecule galectin 8 Hermes antigen integrin podoplanin ALCAM protein, human fetoprotein galectin leukocyte antigen LGALS8 protein, human membrane protein nerve cell adhesion molecule PDPN protein, human angiogenesis Article cell adhesion cell migration endothelium cell human lymph vessel endothelium lymphangiogenesis nonhuman priority journal protein protein interaction serum vascular endothelium carcinogenesis extracellular matrix genetics metabolism metastasis neoplasm neovascularization (pathology) pathology Antigens, CD Carcinogenesis Cell Adhesion Cell Adhesion Molecules, Neuronal Endothelial Cells Extracellular Matrix Fetal Proteins Galectins Humans Membrane Glycoproteins Neoplasm Metastasis Neoplasms Neovascularization, Pathologic
description	Galectin-8 (gal-8) is a "tandem-repeat"-type galectin, containing two carbohydrate recognition domains connected by a linker peptide. gal-8 is expressed both in the cytoplasm and nucleus in vascular endothelial cells (ECs) from normal and tumor-associated blood vessels, and in lymphatic endothelial cells. Herein, we describe a novel role for gal-8 in the regulation of vascular and lymphatic angiogenesis and provide evidence of its critical implications in tumor biology. Functional assays revealed central roles for gal-8 in the control of capillary-tube formation, EC migration and in vivo angiogenesis. So far, two endothelial ligands have been described for gal-8, namely podoplanin in lymphatic vessels and CD166 (ALCAM, activated leukocyte cell adhesion molecule) in vascular ECs. Other related gal-8 functions are also summarized here, including cell adhesion and migration, which collectively demonstrate the multi-functionality of this complex lectin. Thus, gal-8 is an important component of the angiogenesis network, and an essential molecule in the extracellular matrix by providing molecular anchoring to this surrounding matrix. The implications of gal-8 in tumor angiogenesis remain to be further explored, but it is exciting to speculate that modulating gal-8-glycan interactions could be used to block lymphatic-vascular connections vital for metastasis. © The Author 2014. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
author	Troncoso, María Fernanda Elola, María Teresa
author_facet	Troncoso, María Fernanda Elola, María Teresa
author_sort	Troncoso, María Fernanda
title	Galectin-8: A matricellular lectin with key roles in angiogenesis
title_short	Galectin-8: A matricellular lectin with key roles in angiogenesis
title_full	Galectin-8: A matricellular lectin with key roles in angiogenesis
title_fullStr	Galectin-8: A matricellular lectin with key roles in angiogenesis
title_full_unstemmed	Galectin-8: A matricellular lectin with key roles in angiogenesis
title_sort	galectin-8: a matricellular lectin with key roles in angiogenesis
publishDate	2014
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09596658_v24_n10_p907_Troncoso http://hdl.handle.net/20.500.12110/paper_09596658_v24_n10_p907_Troncoso
work_keys_str_mv	AT troncosomariafernanda galectin8amatricellularlectinwithkeyrolesinangiogenesis AT elolamariateresa galectin8amatricellularlectinwithkeyrolesinangiogenesis
_version_	1768543431219478528

Galectin-8: A matricellular lectin with key roles in angiogenesis

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