Deficits in temporal processing in mice prenatally exposed to Valproic Acid
Temporal processing in the seconds-to-minutes range, known as interval timing, is a crucial cognitive function that requires activation of cortico-striatal circuits via dopaminergic–glutamatergic pathways. In humans, both children and adults with autism spectrum disorders (ASD) present alterations i...
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2018
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0953816X_v47_n6_p619_Acosta http://hdl.handle.net/20.500.12110/paper_0953816X_v47_n6_p619_Acosta |
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paper:paper_0953816X_v47_n6_p619_Acosta2023-06-08T15:55:32Z Deficits in temporal processing in mice prenatally exposed to Valproic Acid autism spectrum disorder cortico-striatal circuits dopamine interval timing valproic acid catecholamine dopamine valproic acid accuracy adult animal experiment animal model Article autism cognitive defect controlled study corpus striatum dopamine metabolism dopaminergic system female fetus gender gestational age high performance liquid chromatography male mouse nonhuman prenatal drug exposure priority journal reaction time serotoninergic system social aspect Temporal processing in the seconds-to-minutes range, known as interval timing, is a crucial cognitive function that requires activation of cortico-striatal circuits via dopaminergic–glutamatergic pathways. In humans, both children and adults with autism spectrum disorders (ASD) present alterations in their estimation of time intervals. At present, there are no records of interval timing studies in animal models of ASD. Hence, the objective of the present work was to evaluate interval timing in a mouse model of prenatal exposure to valproic acid (VPA) – a treatment used to induce human-like autistic features in rodent models. Animals were assessed for their ability to acquire timing responses in 15-s and 45-s peak-interval (PI) procedures. Our results indicate that both female and male mice prenatally exposed to VPA present decreased timing accuracy and precision compared to control groups, as well as deviations from the scalar property. Moreover, the observed timing deficits in male VPA mice were reversed after early social enrichment. Furthermore, catecholamine determination by HPLC-ED indicated significant differences in striatal dopaminergic, but not serotonergic, content in female and male VPA mice, consistent with previously identified alterations in dopamine metabolism in ASD. These deficits in temporal processing in a mouse model of autism complement previous results in humans, and provide a useful tool for further behavioral and pharmacological studies. © 2017 Federation of European Neuroscience Societies and John Wiley & Sons Ltd 2018 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0953816X_v47_n6_p619_Acosta http://hdl.handle.net/20.500.12110/paper_0953816X_v47_n6_p619_Acosta |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
autism spectrum disorder cortico-striatal circuits dopamine interval timing valproic acid catecholamine dopamine valproic acid accuracy adult animal experiment animal model Article autism cognitive defect controlled study corpus striatum dopamine metabolism dopaminergic system female fetus gender gestational age high performance liquid chromatography male mouse nonhuman prenatal drug exposure priority journal reaction time serotoninergic system social aspect |
| spellingShingle |
autism spectrum disorder cortico-striatal circuits dopamine interval timing valproic acid catecholamine dopamine valproic acid accuracy adult animal experiment animal model Article autism cognitive defect controlled study corpus striatum dopamine metabolism dopaminergic system female fetus gender gestational age high performance liquid chromatography male mouse nonhuman prenatal drug exposure priority journal reaction time serotoninergic system social aspect Deficits in temporal processing in mice prenatally exposed to Valproic Acid |
| topic_facet |
autism spectrum disorder cortico-striatal circuits dopamine interval timing valproic acid catecholamine dopamine valproic acid accuracy adult animal experiment animal model Article autism cognitive defect controlled study corpus striatum dopamine metabolism dopaminergic system female fetus gender gestational age high performance liquid chromatography male mouse nonhuman prenatal drug exposure priority journal reaction time serotoninergic system social aspect |
| description |
Temporal processing in the seconds-to-minutes range, known as interval timing, is a crucial cognitive function that requires activation of cortico-striatal circuits via dopaminergic–glutamatergic pathways. In humans, both children and adults with autism spectrum disorders (ASD) present alterations in their estimation of time intervals. At present, there are no records of interval timing studies in animal models of ASD. Hence, the objective of the present work was to evaluate interval timing in a mouse model of prenatal exposure to valproic acid (VPA) – a treatment used to induce human-like autistic features in rodent models. Animals were assessed for their ability to acquire timing responses in 15-s and 45-s peak-interval (PI) procedures. Our results indicate that both female and male mice prenatally exposed to VPA present decreased timing accuracy and precision compared to control groups, as well as deviations from the scalar property. Moreover, the observed timing deficits in male VPA mice were reversed after early social enrichment. Furthermore, catecholamine determination by HPLC-ED indicated significant differences in striatal dopaminergic, but not serotonergic, content in female and male VPA mice, consistent with previously identified alterations in dopamine metabolism in ASD. These deficits in temporal processing in a mouse model of autism complement previous results in humans, and provide a useful tool for further behavioral and pharmacological studies. © 2017 Federation of European Neuroscience Societies and John Wiley & Sons Ltd |
| title |
Deficits in temporal processing in mice prenatally exposed to Valproic Acid |
| title_short |
Deficits in temporal processing in mice prenatally exposed to Valproic Acid |
| title_full |
Deficits in temporal processing in mice prenatally exposed to Valproic Acid |
| title_fullStr |
Deficits in temporal processing in mice prenatally exposed to Valproic Acid |
| title_full_unstemmed |
Deficits in temporal processing in mice prenatally exposed to Valproic Acid |
| title_sort |
deficits in temporal processing in mice prenatally exposed to valproic acid |
| publishDate |
2018 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0953816X_v47_n6_p619_Acosta http://hdl.handle.net/20.500.12110/paper_0953816X_v47_n6_p619_Acosta |
| _version_ |
1768544188640526336 |