Therapeutic effect of meliacine, an antiviral derived from Melia azedarach L., in mice genital herpetic infection
Since natural products are considered powerful sources of novel drug discovery, a partially purified extract (meliacine) from the leaves of Melia azedarach L., a plant used in traditional medicine in India for the treatment of several diseases, has been studied. Meliacine exhibits a potent antiviral...
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2009
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0951418X_v23_n12_p1771_Petrera http://hdl.handle.net/20.500.12110/paper_0951418X_v23_n12_p1771_Petrera |
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paper:paper_0951418X_v23_n12_p1771_Petrera2023-06-08T15:54:55Z Therapeutic effect of meliacine, an antiviral derived from Melia azedarach L., in mice genital herpetic infection Antiviral HSV-2 Melia azedarach L. Meliacine Microbicide Mouse genital infection gamma interferon Melia azedarach extract meliacine tumor necrosis factor alpha unclassified drug animal cell animal experiment animal model animal tissue antiviral activity article controlled study disease severity female genital herpes Herpes simplex virus 2 lifespan Melia azedarach mouse nonhuman survival vagina discharge virus shedding virus strain Administration, Intravaginal Animals Antiviral Agents Female Herpes Genitalis Herpesvirus 2, Human Interferon-gamma Medicine, Traditional Melia azedarach Mice Mice, Inbred BALB C Peptides Phytotherapy Plant Extracts Plant Proteins Tumor Necrosis Factor-alpha Vagina Virus Replication Animalia Human herpesvirus 2 Melia azedarach Mus Since natural products are considered powerful sources of novel drug discovery, a partially purified extract (meliacine) from the leaves of Melia azedarach L., a plant used in traditional medicine in India for the treatment of several diseases, has been studied. Meliacine exhibits a potent antiviral effect against several viruses without displaying cytotoxicity. The purpose of the present study was to evaluate the therapeutic effect of intravaginal administration of meliacine in a mouse model of genital herpetic infection. BALB/c female mice were infected with MS or G strains of Herpes Simplex Virus type 2 and then treated with meliacine topically. An overall protective effect was observed. Animal survival increased, the severity of the disease was reduced, life span was extended and virus shedding in vagina fluids was diminished. In addition, meliacine reduced the amount of virus that migrated to the brain and vaginal fluids presented higher levels of IFN- γ and TNF- α than untreated infected mice. These results indicate that meliacine could be an alternative therapeutic compound against HSV-2 genital infection. Copyright © 2009 John Wiley & Sons, Ltd. 2009 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0951418X_v23_n12_p1771_Petrera http://hdl.handle.net/20.500.12110/paper_0951418X_v23_n12_p1771_Petrera |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Antiviral HSV-2 Melia azedarach L. Meliacine Microbicide Mouse genital infection gamma interferon Melia azedarach extract meliacine tumor necrosis factor alpha unclassified drug animal cell animal experiment animal model animal tissue antiviral activity article controlled study disease severity female genital herpes Herpes simplex virus 2 lifespan Melia azedarach mouse nonhuman survival vagina discharge virus shedding virus strain Administration, Intravaginal Animals Antiviral Agents Female Herpes Genitalis Herpesvirus 2, Human Interferon-gamma Medicine, Traditional Melia azedarach Mice Mice, Inbred BALB C Peptides Phytotherapy Plant Extracts Plant Proteins Tumor Necrosis Factor-alpha Vagina Virus Replication Animalia Human herpesvirus 2 Melia azedarach Mus |
| spellingShingle |
Antiviral HSV-2 Melia azedarach L. Meliacine Microbicide Mouse genital infection gamma interferon Melia azedarach extract meliacine tumor necrosis factor alpha unclassified drug animal cell animal experiment animal model animal tissue antiviral activity article controlled study disease severity female genital herpes Herpes simplex virus 2 lifespan Melia azedarach mouse nonhuman survival vagina discharge virus shedding virus strain Administration, Intravaginal Animals Antiviral Agents Female Herpes Genitalis Herpesvirus 2, Human Interferon-gamma Medicine, Traditional Melia azedarach Mice Mice, Inbred BALB C Peptides Phytotherapy Plant Extracts Plant Proteins Tumor Necrosis Factor-alpha Vagina Virus Replication Animalia Human herpesvirus 2 Melia azedarach Mus Therapeutic effect of meliacine, an antiviral derived from Melia azedarach L., in mice genital herpetic infection |
| topic_facet |
Antiviral HSV-2 Melia azedarach L. Meliacine Microbicide Mouse genital infection gamma interferon Melia azedarach extract meliacine tumor necrosis factor alpha unclassified drug animal cell animal experiment animal model animal tissue antiviral activity article controlled study disease severity female genital herpes Herpes simplex virus 2 lifespan Melia azedarach mouse nonhuman survival vagina discharge virus shedding virus strain Administration, Intravaginal Animals Antiviral Agents Female Herpes Genitalis Herpesvirus 2, Human Interferon-gamma Medicine, Traditional Melia azedarach Mice Mice, Inbred BALB C Peptides Phytotherapy Plant Extracts Plant Proteins Tumor Necrosis Factor-alpha Vagina Virus Replication Animalia Human herpesvirus 2 Melia azedarach Mus |
| description |
Since natural products are considered powerful sources of novel drug discovery, a partially purified extract (meliacine) from the leaves of Melia azedarach L., a plant used in traditional medicine in India for the treatment of several diseases, has been studied. Meliacine exhibits a potent antiviral effect against several viruses without displaying cytotoxicity. The purpose of the present study was to evaluate the therapeutic effect of intravaginal administration of meliacine in a mouse model of genital herpetic infection. BALB/c female mice were infected with MS or G strains of Herpes Simplex Virus type 2 and then treated with meliacine topically. An overall protective effect was observed. Animal survival increased, the severity of the disease was reduced, life span was extended and virus shedding in vagina fluids was diminished. In addition, meliacine reduced the amount of virus that migrated to the brain and vaginal fluids presented higher levels of IFN- γ and TNF- α than untreated infected mice. These results indicate that meliacine could be an alternative therapeutic compound against HSV-2 genital infection. Copyright © 2009 John Wiley & Sons, Ltd. |
| title |
Therapeutic effect of meliacine, an antiviral derived from Melia azedarach L., in mice genital herpetic infection |
| title_short |
Therapeutic effect of meliacine, an antiviral derived from Melia azedarach L., in mice genital herpetic infection |
| title_full |
Therapeutic effect of meliacine, an antiviral derived from Melia azedarach L., in mice genital herpetic infection |
| title_fullStr |
Therapeutic effect of meliacine, an antiviral derived from Melia azedarach L., in mice genital herpetic infection |
| title_full_unstemmed |
Therapeutic effect of meliacine, an antiviral derived from Melia azedarach L., in mice genital herpetic infection |
| title_sort |
therapeutic effect of meliacine, an antiviral derived from melia azedarach l., in mice genital herpetic infection |
| publishDate |
2009 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0951418X_v23_n12_p1771_Petrera http://hdl.handle.net/20.500.12110/paper_0951418X_v23_n12_p1771_Petrera |
| _version_ |
1768543430464503808 |