Neonatal, placental, and umbilical cord blood parameters in pregnant women residing in areas with intensive pesticide application
In rural populations, the proximity to areas with intensive pesticide application represents a risk factor of xenobiotic exposure. Here, we investigated whether newborns born to mothers residing in an area with intensive pesticide application show alterations in placental and neonatal morphometric s...
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2017
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09441344_v24_n25_p20736_Quintana http://hdl.handle.net/20.500.12110/paper_09441344_v24_n25_p20736_Quintana |
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paper:paper_09441344_v24_n25_p20736_Quintana2023-06-08T15:53:41Z Neonatal, placental, and umbilical cord blood parameters in pregnant women residing in areas with intensive pesticide application DNA damage Neonate parameters Osmotic fragility Residential exposure Superoxide dismutase Umbilical cord blood biomarker blood DNA enzyme enzyme activity health risk neonate osmosis oxidative stress pesticide application pregnancy public health risk factor rural area rural population urban population womens health biological marker pesticide adolescent adult Argentina blood chemistry female fetus blood human newborn oxidative stress placenta pregnancy rural population urban population vascularization young adult Adolescent Adult Argentina Biomarkers Female Fetal Blood Humans Infant, Newborn Oxidative Stress Pesticides Placenta Pregnancy Rural Population Urban Population Young Adult In rural populations, the proximity to areas with intensive pesticide application represents a risk factor of xenobiotic exposure. Here, we investigated whether newborns born to mothers residing in an area with intensive pesticide application show alterations in placental and neonatal morphometric standards, umbilical cord blood (UCB) biochemical parameters, and/or biomarkers related to oxidative stress and oxidative damage. Samples were collected from 151 healthy pregnant women residing in a rural area (rural group; RG) during the pesticide spraying (SS) and nonspraying (NSS) seasons, as well as from women from an urban population (control group; CG), and grouped according to the delivery type (vaginal or cesarean). In the vaginal delivery group, the placental weight and placental index were higher in the RG groups than in the CG (p = 0.01), whereas in the cesarean delivery group, newborn weight was lower in the RG-SS group than in the CG. In the RG-SS group, UCB erythrocyte osmotic fragility and the DNA damage index (DI) were higher, and superoxide dismutase (SOD) activity was lower than in the RG-NSS group. Acetylcholinesterase and SOD activities were found to be inversely correlated with the DI. © 2017, Springer-Verlag GmbH Germany. 2017 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09441344_v24_n25_p20736_Quintana http://hdl.handle.net/20.500.12110/paper_09441344_v24_n25_p20736_Quintana |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
DNA damage Neonate parameters Osmotic fragility Residential exposure Superoxide dismutase Umbilical cord blood biomarker blood DNA enzyme enzyme activity health risk neonate osmosis oxidative stress pesticide application pregnancy public health risk factor rural area rural population urban population womens health biological marker pesticide adolescent adult Argentina blood chemistry female fetus blood human newborn oxidative stress placenta pregnancy rural population urban population vascularization young adult Adolescent Adult Argentina Biomarkers Female Fetal Blood Humans Infant, Newborn Oxidative Stress Pesticides Placenta Pregnancy Rural Population Urban Population Young Adult |
| spellingShingle |
DNA damage Neonate parameters Osmotic fragility Residential exposure Superoxide dismutase Umbilical cord blood biomarker blood DNA enzyme enzyme activity health risk neonate osmosis oxidative stress pesticide application pregnancy public health risk factor rural area rural population urban population womens health biological marker pesticide adolescent adult Argentina blood chemistry female fetus blood human newborn oxidative stress placenta pregnancy rural population urban population vascularization young adult Adolescent Adult Argentina Biomarkers Female Fetal Blood Humans Infant, Newborn Oxidative Stress Pesticides Placenta Pregnancy Rural Population Urban Population Young Adult Neonatal, placental, and umbilical cord blood parameters in pregnant women residing in areas with intensive pesticide application |
| topic_facet |
DNA damage Neonate parameters Osmotic fragility Residential exposure Superoxide dismutase Umbilical cord blood biomarker blood DNA enzyme enzyme activity health risk neonate osmosis oxidative stress pesticide application pregnancy public health risk factor rural area rural population urban population womens health biological marker pesticide adolescent adult Argentina blood chemistry female fetus blood human newborn oxidative stress placenta pregnancy rural population urban population vascularization young adult Adolescent Adult Argentina Biomarkers Female Fetal Blood Humans Infant, Newborn Oxidative Stress Pesticides Placenta Pregnancy Rural Population Urban Population Young Adult |
| description |
In rural populations, the proximity to areas with intensive pesticide application represents a risk factor of xenobiotic exposure. Here, we investigated whether newborns born to mothers residing in an area with intensive pesticide application show alterations in placental and neonatal morphometric standards, umbilical cord blood (UCB) biochemical parameters, and/or biomarkers related to oxidative stress and oxidative damage. Samples were collected from 151 healthy pregnant women residing in a rural area (rural group; RG) during the pesticide spraying (SS) and nonspraying (NSS) seasons, as well as from women from an urban population (control group; CG), and grouped according to the delivery type (vaginal or cesarean). In the vaginal delivery group, the placental weight and placental index were higher in the RG groups than in the CG (p = 0.01), whereas in the cesarean delivery group, newborn weight was lower in the RG-SS group than in the CG. In the RG-SS group, UCB erythrocyte osmotic fragility and the DNA damage index (DI) were higher, and superoxide dismutase (SOD) activity was lower than in the RG-NSS group. Acetylcholinesterase and SOD activities were found to be inversely correlated with the DI. © 2017, Springer-Verlag GmbH Germany. |
| title |
Neonatal, placental, and umbilical cord blood parameters in pregnant women residing in areas with intensive pesticide application |
| title_short |
Neonatal, placental, and umbilical cord blood parameters in pregnant women residing in areas with intensive pesticide application |
| title_full |
Neonatal, placental, and umbilical cord blood parameters in pregnant women residing in areas with intensive pesticide application |
| title_fullStr |
Neonatal, placental, and umbilical cord blood parameters in pregnant women residing in areas with intensive pesticide application |
| title_full_unstemmed |
Neonatal, placental, and umbilical cord blood parameters in pregnant women residing in areas with intensive pesticide application |
| title_sort |
neonatal, placental, and umbilical cord blood parameters in pregnant women residing in areas with intensive pesticide application |
| publishDate |
2017 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09441344_v24_n25_p20736_Quintana http://hdl.handle.net/20.500.12110/paper_09441344_v24_n25_p20736_Quintana |
| _version_ |
1768542184713224192 |