Antimicrobial and antioxidant activities of Gentianella multicaulis collected on the Andean slopes of San Juan Province, Argentina

The infusion of the aerial parts of Gentianella multicaulis (Gillies ex Griseb.) Fabris (Gentianaceae), locally known as 'nencia', is used in San Juan Province, Argentina, as stomachic and as a bitter tonic against digestive and liver problems. The bioassay-guided isolation of G. multicaul...

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Detalles Bibliográficos
Autor principal: Palermo, Jorge Alejandro
Publicado: 2012
Materias:
Antifungal activity
Antioxidant activity
Gentianella multicaulis
Trichophyton spp.
antiinfective agent
antioxidant
scavenger
Argentina
article
chemistry
Gentianella
high performance liquid chromatography
microbiological examination
nuclear magnetic resonance spectroscopy
Anti-Infective Agents
Antioxidants
Chromatography, High Pressure Liquid
Free Radical Scavengers
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Arthroderma benhamiae
Arthroderma gypseum
Arthrodermataceae
Gentianaceae
Trichophyton
Trichophyton rubrum
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09395075_v67_n1-2_p29_Lima
http://hdl.handle.net/20.500.12110/paper_09395075_v67_n1-2_p29_Lima
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_09395075_v67_n1-2_p29_Lima
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spelling paper:paper_09395075_v67_n1-2_p29_Lima2023-06-08T15:53:28Z Antimicrobial and antioxidant activities of Gentianella multicaulis collected on the Andean slopes of San Juan Province, Argentina Palermo, Jorge Alejandro Antifungal activity Antioxidant activity Gentianella multicaulis Trichophyton spp. antiinfective agent antioxidant scavenger Argentina article chemistry Gentianella high performance liquid chromatography microbiological examination nuclear magnetic resonance spectroscopy Anti-Infective Agents Antioxidants Argentina Chromatography, High Pressure Liquid Free Radical Scavengers Gentianella Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Arthroderma benhamiae Arthroderma gypseum Arthrodermataceae Gentianaceae Gentianella Trichophyton Trichophyton rubrum The infusion of the aerial parts of Gentianella multicaulis (Gillies ex Griseb.) Fabris (Gentianaceae), locally known as 'nencia', is used in San Juan Province, Argentina, as stomachic and as a bitter tonic against digestive and liver problems. The bioassay-guided isolation of G. multicaulis extracts and structural elucidation of the main compounds responsible for the antifungal and free radical scavenging activities were performed. The extracts had strong free radical scavenging effects in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay (45-93% at 10 μg/mL) and ferric-reducing antioxidant power (FRAP) assay at 200 μg/mL. Demethylbellidifolin (4) had high antioxidant activity in the DPPH and FRAP assay. The dermatophytes Microsporum gypseum, Trichophyton mentagrophytes, and T. rubrum were moderately inhibited by the different extracts (MIC values of 125-250 μg/mL). Demethylbellidifolin (4), bellidifolin (5), and isobellidifolin (6) showed an antifungal effect (MIC values of 50 μg/mL), while swerchirin (3) was less active with a MIC value of 100 μg/mL. In addition, oleanolic acid (1) and ursolic acid (2) were also isolated. These findings demonstrate that Gentianella multicaulis collected in the mountains of the Province of San Juan, Argentina, is an important source of compounds with antifungal and antioxidant activities. © 2012 Verlag der Zeitschrift für Naturforschung, Tübingen. Fil:Palermo, J.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2012 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09395075_v67_n1-2_p29_Lima http://hdl.handle.net/20.500.12110/paper_09395075_v67_n1-2_p29_Lima
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Antifungal activity
Antioxidant activity
Gentianella multicaulis
Trichophyton spp.
antiinfective agent
antioxidant
scavenger
Argentina
article
chemistry
Gentianella
high performance liquid chromatography
microbiological examination
nuclear magnetic resonance spectroscopy
Anti-Infective Agents
Antioxidants
Argentina
Chromatography, High Pressure Liquid
Free Radical Scavengers
Gentianella
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Arthroderma benhamiae
Arthroderma gypseum
Arthrodermataceae
Gentianaceae
Gentianella
Trichophyton
Trichophyton rubrum
spellingShingle Antifungal activity
Antioxidant activity
Gentianella multicaulis
Trichophyton spp.
antiinfective agent
antioxidant
scavenger
Argentina
article
chemistry
Gentianella
high performance liquid chromatography
microbiological examination
nuclear magnetic resonance spectroscopy
Anti-Infective Agents
Antioxidants
Argentina
Chromatography, High Pressure Liquid
Free Radical Scavengers
Gentianella
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Arthroderma benhamiae
Arthroderma gypseum
Arthrodermataceae
Gentianaceae
Gentianella
Trichophyton
Trichophyton rubrum
Palermo, Jorge Alejandro
Antimicrobial and antioxidant activities of Gentianella multicaulis collected on the Andean slopes of San Juan Province, Argentina
topic_facet Antifungal activity
Antioxidant activity
Gentianella multicaulis
Trichophyton spp.
antiinfective agent
antioxidant
scavenger
Argentina
article
chemistry
Gentianella
high performance liquid chromatography
microbiological examination
nuclear magnetic resonance spectroscopy
Anti-Infective Agents
Antioxidants
Argentina
Chromatography, High Pressure Liquid
Free Radical Scavengers
Gentianella
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Arthroderma benhamiae
Arthroderma gypseum
Arthrodermataceae
Gentianaceae
Gentianella
Trichophyton
Trichophyton rubrum
description The infusion of the aerial parts of Gentianella multicaulis (Gillies ex Griseb.) Fabris (Gentianaceae), locally known as 'nencia', is used in San Juan Province, Argentina, as stomachic and as a bitter tonic against digestive and liver problems. The bioassay-guided isolation of G. multicaulis extracts and structural elucidation of the main compounds responsible for the antifungal and free radical scavenging activities were performed. The extracts had strong free radical scavenging effects in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay (45-93% at 10 μg/mL) and ferric-reducing antioxidant power (FRAP) assay at 200 μg/mL. Demethylbellidifolin (4) had high antioxidant activity in the DPPH and FRAP assay. The dermatophytes Microsporum gypseum, Trichophyton mentagrophytes, and T. rubrum were moderately inhibited by the different extracts (MIC values of 125-250 μg/mL). Demethylbellidifolin (4), bellidifolin (5), and isobellidifolin (6) showed an antifungal effect (MIC values of 50 μg/mL), while swerchirin (3) was less active with a MIC value of 100 μg/mL. In addition, oleanolic acid (1) and ursolic acid (2) were also isolated. These findings demonstrate that Gentianella multicaulis collected in the mountains of the Province of San Juan, Argentina, is an important source of compounds with antifungal and antioxidant activities. © 2012 Verlag der Zeitschrift für Naturforschung, Tübingen.
author Palermo, Jorge Alejandro
author_facet Palermo, Jorge Alejandro
author_sort Palermo, Jorge Alejandro
title Antimicrobial and antioxidant activities of Gentianella multicaulis collected on the Andean slopes of San Juan Province, Argentina
title_short Antimicrobial and antioxidant activities of Gentianella multicaulis collected on the Andean slopes of San Juan Province, Argentina
title_full Antimicrobial and antioxidant activities of Gentianella multicaulis collected on the Andean slopes of San Juan Province, Argentina
title_fullStr Antimicrobial and antioxidant activities of Gentianella multicaulis collected on the Andean slopes of San Juan Province, Argentina
title_full_unstemmed Antimicrobial and antioxidant activities of Gentianella multicaulis collected on the Andean slopes of San Juan Province, Argentina
title_sort antimicrobial and antioxidant activities of gentianella multicaulis collected on the andean slopes of san juan province, argentina
publishDate 2012
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09395075_v67_n1-2_p29_Lima
http://hdl.handle.net/20.500.12110/paper_09395075_v67_n1-2_p29_Lima
work_keys_str_mv AT palermojorgealejandro antimicrobialandantioxidantactivitiesofgentianellamulticauliscollectedontheandeanslopesofsanjuanprovinceargentina
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